NAME: Nemo

ID ApprovedSymbol EntrezGene HGNC UniGeneID Affymetrics HugoName UniGeneName GeneOntologyID ENSG ENSP KEGGID ApprovedSymbol2 PreviousSymbols NCIName Evidence Chromosome Status Reactome_ID Aliases StringSymbol StringName
472 ATM 472 HGNC:795 Hs.367437 1553387_at
1554631_at
1570352_at
208442_s_at
210858_x_at
212672_at
ataxia telangiectasia mutated Ataxia telangiectasia mutated ENSG00000149311 ENSP00000278616 hsa+472 ATM ATA, ATDC, ATC, ATD ATM 11q22-q23 Approved TEL1, TELO1 ATM ataxia telangiectasia mutated; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]-Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also involved in signal transduction and cell cycle control. May function as a tumor suppressor. Necessary for activation of ABL1 and SAPK. Phosphorylate [...]
329 BIRC2 329 HGNC:590 Hs.696238 202076_at
baculoviral IAP repeat-containing 2 Baculoviral IAP repeat-containing 2 ENSG00000110330 ENSP00000227758 hsa+329 BIRC2 API1 BIRC2 11q22 Approved cIAP1, hiap-2, MIHB, RNF48 MIHB baculoviral IAP repeat-containing 2; Apoptotic suppressor. The BIR motifs region interacts with TNF receptor associated factors 1 and 2 (TRAF1 and TRAF2) to form an heteromeric complex, which is then recruited to the tumor necrosis factor receptor 2 (TNFR2)
1147 CHUK 1147 HGNC:1974 Hs.198998 209666_s_at
conserved helix-loop-helix ubiquitous kinase Conserved helix-loop-helix ubiquitous kinase ENSG00000213341 ENSP00000359424 hsa+1147 CHUK TCF16 CHUK 10q24-q25 Approved REACT_6900 IKK1, IKK-alpha, IkBKA, NFKBIKA, IKKA - conserved helix-loop-helix ubiquitous kinase; Acts as part of the IKK complex in the conventional pathway of NF-kappa-B activation and phosphorylates inhibitors of NF-kappa-B thus leading to the dissociation of the inhibitor/NF- kappa-B complex and ultimately the degradation of the inhibitor. As part of the non-canonical pathway of NF-kappa-B activation, the MAP3K14-activated CHUK/IKKA homodimer phosphorylates NFKB2/p100 associated with RelB, inducing its proteolytic processing to NFKB2/p52 and the formation of NF-kappa-B RelB-p52 complexes. Also phosphorylates NCOA3. Phosphorylates 'S [...]
23085 ERC1 23085 HGNC:17072 1552663_a_at
1555294_a_at
1563947_a_at
215606_s_at
216440_at
226049_at
235820_at
ELKS/RAB6-interacting/CAST family member 1 ENSG00000082805 ERC1 RAB6IP2 12p13.3 Approved
3551 IKBKB 3551 HGNC:5960 Hs.656458 209341_s_at
209342_s_at
211027_s_at
inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta Inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta ENSG00000104365 ENSP00000339151 hsa+3551 IKBKB IKBKB 8p11.2 Approved REACT_6900 IKK2, NFKBIKB, IKK-beta, IKKB IKKB inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta; Acts as part of the IKK complex in the conventional pathway of NF-kappa-B activation and phosphorylates inhibitors of NF-kappa-B thus leading to the dissociation of the inhibitor/NF- kappa-B complex and ultimately the degradation of the inhibitor. Also phosphorylates NCOA3
8517 IKBKG 8517 HGNC:5961 Hs.43505 209929_s_at
36004_at
inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma Inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma ENSG00000073009 ENSP00000358622 hsa+8517 IKBKG IP2, IP1 IKBKG Xq28 Approved REACT_6900 IKK-gamma, NEMO, Fip3p, FIP-3, FIP3 IKBKG inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma; Regulatory subunit of the IKK core complex which phosphorylates inhibitors of NF-kappa-B thus leading to the dissociation of the inhibitor/NF-kappa-B complex and ultimately the degradation of the inhibitor. Also considered to be a mediator for TAX activation of NF-kappa-B. Could be implicated in NF-kappa- B-mediated protection from cytokine toxicity (By similarity)
55367 LRDD 55367 HGNC:16491 Hs.592290 leucine-rich repeats and death domain containing Leucine-rich repeats and death domain containing ENSG00000177595 ENSP00000337797 LRDD LRDD 11p15.5 Approved PIDD, MGC16925, DKFZp434D229 PIDD leucine-rich repeats and death domain containing; Promotes apoptosis downstream of the tumor suppressor as component of the DNA damage/stress response pathway that connects p53/TP53 to apoptosis. Associates with NEMO/IKBKG and RIP1 and enhances sumoylation and ubiquitination of NEMO/IKBKG which is important for activation of the transcription factor NF-kappa-B. Associates with CASP2/caspase-2 and CRADD/RAIDD, and induces activation of CASP2 which an important regulator in apoptotic pathways
23118 MAP3K7IP2 23118 HGNC:17075 Hs.269775 210284_s_at
212184_s_at
mitogen-activated protein kinase kinase kinase 7 interacting protein 2 Mitogen-activated protein kinase kinase kinase 7 interacting protein 2 ENSG00000055208 ENSP00000356426 MAP3K7IP2 MAP3K7IP2 6q25.1 Approved TAB2, KIAA0733 MAP3K7IP2 mitogen-activated protein kinase kinase kinase 7 interacting protein 2; Adapter linking MAP3K7/TAK1 and TRAF6 and mediator of MAP3K7 activation in the IL1 signaling pathway
4361 MRE11A 4361 HGNC:7230 Hs.192649 205395_s_at
211334_at
242456_at
MRE11 meiotic recombination 11 homolog A (S. cerevisiae) MRE11 meiotic recombination 11 homolog A (S. cerevisiae) ENSG00000020922 ENSP00000325863 hsa+4361 MRE11A MRE11 MRE11A 11q21 Approved ATLD MRE11A MRE11 meiotic recombination 11 homolog A (S. cerevisiae); Component of the MRN complex, which plays a central role in double-strand break (DSB) repair, DNA recombination, maintenance of telomere integrity and meiosis. The complex possesses single-strand endonuclease activity and double-strand- specific 3'-5' exonuclease activity, which are provided by MRE11A. RAD50 may be required to bind DNA ends and hold them in close proximity. This could facilitate searches for short or long regions of sequence homology in the recombining DNA templates, and may also stimulate the activity of DNA li [...]
4683 NBN 4683 HGNC:7652 Hs.492208 202905_x_at
202906_s_at
202907_s_at
217299_s_at
240510_at
nibrin Nibrin ENSG00000104320 ENSP00000265433 hsa+4683 NBN NBS, NBS1 NBN 8q21-q24 Approved ATV, AT-V2, AT-V1 NBN nibrin; Component of the MRE11/RAD50/NBN (MRN complex) which plays a critical role in the cellular response to DNA damage and the maintenance of chromosome integrity. The complex is involved in double-strand break (DSB) repair, DNA recombination, maintenance of telomere integrity, cell cycle checkpoint control and meiosis. The complex possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity, which are provided by MRE11A. RAD50 may be required to bind DNA ends and hold them in close proximity. NBN modulate the DNA damage signal sensing by recru [...]
4790 NFKB1 4790 HGNC:7794 Hs.654408 209239_at
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 Nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 ENSG00000109320 ENSP00000226574 hsa+4790 NFKB1 NFKB1 4q24 Approved REACT_6900 KBF1, p105, NFKB-p50, p50, NF-kappabeta KBF1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1; NF-kappa-B is a pleiotropic transcription factor which is present in almost all cell types and is involved in many biological processed such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. NF- kappa-B is a homo- or heterodimeric complex formed by the Rel-like domain-containing proteins RELA/p65, RELB, NFKB1/p105, NFKB1/p50, REL and NFKB2/p52 and the heterodimeric p65-p50 complex appears to be most abundant one. The dimers bind at kappa-B sites in the DNA of their target genes and [...]
7182 NR2C2 7182 HGNC:7972 206038_s_at
225477_s_at
nuclear receptor subfamily 2, group C, member 2 ENSG00000177463 NR2C2 TR4 3p25 Approved
142 PARP1 142 HGNC:270 Hs.177766 208644_at
poly (ADP-ribose) polymerase 1 Poly (ADP-ribose) polymerase 1 ENSG00000143799 ENSP00000355759 hsa+142 PARP1 PPOL, ADPRT PARP1 1q41-q42 Approved PARP PARP1 poly (ADP-ribose) polymerase 1; Involved in the base excision repair (BER) pathway, by catalyzing the poly(ADP-ribosyl)ation of a limited number of acceptor proteins involved in chromatin architecture and in DNA metabolism. This modification follows DNA damages and appears as an obligatory step in a detection/signaling pathway leading to the reparation of DNA strand breaks. Mediates the poly(ADP- ribosyl)ation of APLF and CHFR. Positively regulates the transcription of MTUS1 and negatively regulates the transcription of MTUS2/TIP150
51588 PIAS4 51588 HGNC:17002 212879_x_at
212881_at
protein inhibitor of activated STAT, 4 PIAS4 19p13.3 Approved
10111 RAD50 10111 HGNC:9816 Hs.655835 208393_s_at
209349_at
RAD50 homolog (S. cerevisiae) RAD50 homolog (S. cerevisiae) ENSG00000113522 ENSP00000265335 hsa+10111 RAD50 RAD50 5q23-q31 Approved hRad50, RAD50-2 RAD50 RAD50 homolog (S. cerevisiae); Component of the MRN complex, which plays a central role in double-strand break (DSB) repair, DNA recombination, maintenance of telomere integrity and meiosis. The complex possesses single-strand endonuclease activity and double-strand- specific 3'-5' exonuclease activity, which are provided by MRE11A. RAD50 may be required to bind DNA ends and hold them in close proximity. This could facilitate searches for short or long regions of sequence homology in the recombining DNA templates, and may also stimulate the activity of DNA ligases and/or restrict the n [...]
5970 RELA 5970 HGNC:9955 Hs.502875 201783_s_at
209878_s_at
230202_at
v-rel reticuloendotheliosis viral oncogene homolog A (avian) V-rel reticuloendotheliosis viral oncogene homolog A (avian) GO:0006916 ENSG00000173039 ENSP00000384273 hsa+5970 RELA NFKB3 RELA IDA 11q13 Approved REACT_6900 p65 RELA v-rel reticuloendotheliosis viral oncogene homolog A (avian); NF-kappa-B is a pleiotropic transcription factor which is present in almost all cell types and is involved in many biological processed such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. NF- kappa-B is a homo- or heterodimeric complex formed by the Rel-like domain-containing proteins RELA/p65, RELB, NFKB1/p105, NFKB1/p50, REL and NFKB2/p52 and the heterodimeric p65-p50 complex appears to be most abundant one. The dimers bind at kappa-B sites in the DNA of their target genes and the ind [...]
8737 RIPK1 8737 HGNC:10019 Hs.519842 209941_at
226551_at
receptor (TNFRSF)-interacting serine-threonine kinase 1 Receptor (TNFRSF)-interacting serine-threonine kinase 1 GO:0008633 ENSG00000137275 ENSP00000259808 hsa+8737 RIPK1 RIPK1 EXP 6p25.2 Approved REACT_578 REACT_6900 RIP RIPK1 receptor (TNFRSF)-interacting serine-threonine kinase 1; Involved in the transduction of TNF signaling. TNF stimulation induces binding of RIPK1-TRADD-TRAF2-TRAF5 complex to TNFR1. TRAF proteins then catalyze the 'Lys-63'-linked polyubiquitination of RIPK1, inducing RIPK1 association with the IKK complex, which is subsequently activated, leading ultimately to the activation of NF-kappa-B. The inflammatory response is kept transient by the action of the NF-kappa-B target gene product TNFAIP3. TNFAIP3 is recruited to RIPK1 within a complex comprising also RNF11, ITCH and TAX1BP1. TNFAIP3 [...]
7189 TRAF6 7189 HGNC:12036 205558_at
TNF receptor-associated factor 6 TRAF6 11p12 Approved
7334 UBE2N 7334 HGNC:12492 Hs.524630 201523_x_at
201524_x_at
212751_at
ubiquitin-conjugating enzyme E2N (UBC13 homolog, yeast) Ubiquitin-conjugating enzyme E2N (UBC13 homolog, yeast) GO:0000724 ENSG00000177889 ENSP00000316176 UBE2N UBE2N IMP 12q22 Approved UbcH-ben, UBC13, MGC8489 UBE2N ubiquitin-conjugating enzyme E2N (UBC13 homolog, yeast); The UBE2V2/UBE2N heterodimer catalyzes the synthesis of non-canonical poly-ubiquitin chains that are linked through 'Lys- 63'. This type of poly-ubiquitination does not lead to protein degradation by the proteasome. Mediates transcriptional activation of target genes. Plays a role in the control of progress through the cell cycle and differentiation. Plays a role in the error-free DNA repair pathway and contributes to the survival of cells after DNA damage. Acts together with the E3 ligases, HLTF and SHPRH, in the 'Lys-63'-linked [...]
331 XIAP 331 HGNC:592 Hs.356076 206536_s_at
206537_at
225858_s_at
225859_at
228363_at
235222_x_at
243026_x_at
X-linked inhibitor of apoptosis X-linked inhibitor of apoptosis ENSG00000101966 ENSP00000347858 hsa+331 XIAP API3, BIRC4 XIAP Xq25 Approved REACT_578 hILP BIRC4 X-linked inhibitor of apoptosis; Apoptotic suppressor. Has E3 ubiquitin-protein ligase activity. Mediates the proteasomal degradation of target proteins, such as caspase-3, SMAC or AIFM1. Inhibitor of caspase-3, -7 and -9. Mediates activation of MAP3K7/TAK1, leading to the activation of NF-kappa-B
20 genes found.

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ID ApprovedSymbol EntrezGene HGNC
UniGeneID HugoName UniGeneName GeneOntologyID
ENSG ENSP KEGGID ApprovedSymbol2
PreviousSymbols NCIName Evidence Chromosome
Status Reactome_ID Aliases StringSymbol
StringName Affymetrics


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