NAME: Regulation_of_p38-alpha_and_p38-beta

ID ApprovedSymbol EntrezGene HGNC UniGeneID Affymetrics HugoName UniGeneName GeneOntologyID ENSG ENSP KEGGID ApprovedSymbol2 PreviousSymbols NCIName Evidence Chromosome Status Reactome_ID Aliases StringSymbol StringName
409 ARRB2 409 HGNC:712 203388_at
arrestin, beta 2 ENSG00000141480 ARR2 17p13 Approved
472 ATM 472 HGNC:795 Hs.367437 1553387_at
1554631_at
1570352_at
208442_s_at
210858_x_at
212672_at
ataxia telangiectasia mutated Ataxia telangiectasia mutated ENSG00000149311 ENSP00000278616 hsa+472 ATM ATA, ATDC, ATC, ATD ATM 11q22-q23 Approved TEL1, TELO1 ATM ataxia telangiectasia mutated; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]-Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also involved in signal transduction and cell cycle control. May function as a tumor suppressor. Necessary for activation of ABL1 and SAPK. Phosphorylate [...]
602 BCL3 602 HGNC:998 204907_s_at
204908_s_at
B-cell CLL/lymphoma 3 ENSG00000069399 D19S37, BCL4 19q13.1-q13.2 Approved
1147 CHUK 1147 HGNC:1974 Hs.198998 209666_s_at
conserved helix-loop-helix ubiquitous kinase Conserved helix-loop-helix ubiquitous kinase ENSG00000213341 ENSP00000359424 hsa+1147 CHUK TCF16 CHUK 10q24-q25 Approved REACT_6900 IKK1, IKK-alpha, IkBKA, NFKBIKA, IKKA - conserved helix-loop-helix ubiquitous kinase; Acts as part of the IKK complex in the conventional pathway of NF-kappa-B activation and phosphorylates inhibitors of NF-kappa-B thus leading to the dissociation of the inhibitor/NF- kappa-B complex and ultimately the degradation of the inhibitor. As part of the non-canonical pathway of NF-kappa-B activation, the MAP3K14-activated CHUK/IKKA homodimer phosphorylates NFKB2/p100 associated with RelB, inducing its proteolytic processing to NFKB2/p52 and the formation of NF-kappa-B RelB-p52 complexes. Also phosphorylates NCOA3. Phosphorylates 'S [...]
1457 CSNK2A1 1457 HGNC:2457 206075_s_at
212072_s_at
212073_at
212075_s_at
229216_s_at
casein kinase 2, alpha 1 polypeptide ENSG00000101266 CSNK2A1 20p13 Approved
1540 CYLD 1540 HGNC:2584 213295_at
214272_at
221903_s_at
221905_at
222142_at
39582_at
60084_at
cylindromatosis (turban tumor syndrome) ENSP00000308928 CYLD CYLD1 16q12-q13 Approved KIAA0849, USPL2 cylindromatosis (turban tumor syndrome); Negative regulator of TRAF2 and NF-kappa-B signaling pathway. Has deubiquitinating activity that is directed towards non-'Lys-48'-linked polyubiquitin chains. The inhibition of NF- kappa-B activation is mediated at least in part, by the deubiquitination and inactivation of TRAF2 and, to a lesser extent, TRAF6
23085 ERC1 23085 HGNC:17072 1552663_a_at
1555294_a_at
1563947_a_at
215606_s_at
216440_at
226049_at
235820_at
ELKS/RAB6-interacting/CAST family member 1 ENSG00000082805 ERC1 RAB6IP2 12p13.3 Approved
3551 IKBKB 3551 HGNC:5960 Hs.656458 209341_s_at
209342_s_at
211027_s_at
inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta Inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta ENSG00000104365 ENSP00000339151 hsa+3551 IKBKB IKBKB 8p11.2 Approved REACT_6900 IKK2, NFKBIKB, IKK-beta, IKKB IKKB inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta; Acts as part of the IKK complex in the conventional pathway of NF-kappa-B activation and phosphorylates inhibitors of NF-kappa-B thus leading to the dissociation of the inhibitor/NF- kappa-B complex and ultimately the degradation of the inhibitor. Also phosphorylates NCOA3
8517 IKBKG 8517 HGNC:5961 Hs.43505 209929_s_at
36004_at
inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma Inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma ENSG00000073009 ENSP00000358622 hsa+8517 IKBKG IP2, IP1 IKBKG Xq28 Approved REACT_6900 IKK-gamma, NEMO, Fip3p, FIP-3, FIP3 IKBKG inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma; Regulatory subunit of the IKK core complex which phosphorylates inhibitors of NF-kappa-B thus leading to the dissociation of the inhibitor/NF-kappa-B complex and ultimately the degradation of the inhibitor. Also considered to be a mediator for TAX activation of NF-kappa-B. Could be implicated in NF-kappa- B-mediated protection from cytokine toxicity (By similarity)
3932 LCK 3932 HGNC:6524 204890_s_at
204891_s_at
lymphocyte-specific protein tyrosine kinase ENSG00000182866 1p34.3 Approved
4214 MAP3K1 4214 HGNC:6848 Hs.657756 214786_at
225927_at
mitogen-activated protein kinase kinase kinase 1 Mitogen-activated protein kinase kinase kinase 1 ENSG00000095015 ENSP00000382423 MAP3K1 MEKK1 MAP3K1 5q11.2 Approved REACT_6900 MEKK, MAPKKK1 MEKK mitogen-activated protein kinase kinase kinase 1; Component of a protein kinase signal transduction cascade. Activates the ERK and JNK kinase pathways by phosphorylation of MAP2K1 and MAP2K4. Activates CHUK and IKBKB, the central protein kinases of the NF-kappa-B pathway
4294 MAP3K10 4294 HGNC:6849 206362_x_at
mitogen-activated protein kinase kinase kinase 10 MLK2 19q13.2 Approved
4296 MAP3K11 4296 HGNC:6850 1558984_at
203652_at
mitogen-activated protein kinase kinase kinase 11 ENSG00000173327 MLK3, PTK1 11q13.1-q13.3 Approved
7786 MAP3K12 7786 HGNC:6851 205447_s_at
205448_s_at
mitogen-activated protein kinase kinase kinase 12 ENSG00000139625 ZPK 12q13.13 Approved
9175 MAP3K13 9175 HGNC:6852 1562440_at
206249_at
211083_s_at
226190_at
226556_at
229771_at
233508_at
mitogen-activated protein kinase kinase kinase 13 ENSG00000073803 3q27 Approved
9020 MAP3K14 9020 HGNC:6853 Hs.404183 205192_at
mitogen-activated protein kinase kinase kinase 14 Mitogen-activated protein kinase kinase kinase 14 ENSG00000006062 ENSP00000342059 hsa+9020 MAP3K14 MAP3K14 17q21-q22 Approved NIK, HSNIK, FTDCR1B, HS HSNIK mitogen-activated protein kinase kinase kinase 14; Lymphotoxin beta-activated kinase which seems to be exclusively involved in the activation of NF-kappa-B and its transcriptional activity. Induces the processing of NF-kappa-B 2/P100. Could act in a receptor-selective manner (By similarity)
10746 MAP3K2 10746 HGNC:6854 1565130_at
1565131_x_at
221695_s_at
226441_at
226979_at
227073_at
235011_at
235254_at
mitogen-activated protein kinase kinase kinase 2 ENSG00000169967 MEKK2 2q21.1 Approved
4215 MAP3K3 4215 HGNC:6855 203514_at
227131_at
243505_at
mitogen-activated protein kinase kinase kinase 3 ENSP00000354927 MAP3K3 MEKK3 17q Approved MAPKKK3 mitogen-activated protein kinase kinase kinase 3; Component of a protein kinase signal transduction cascade. Mediates activation of the NF-kappa-B, AP1 and DDIT3 transcriptional regulators
4216 MAP3K4 4216 HGNC:6856 204089_x_at
216199_s_at
mitogen-activated protein kinase kinase kinase 4 ENSG00000085511 MEKK4 6q26 Approved
4217 MAP3K5 4217 HGNC:6857 Hs.186486 203836_s_at
203837_at
mitogen-activated protein kinase kinase kinase 5 Mitogen-activated protein kinase kinase kinase 5 ENSG00000197442 ENSP00000351908 MAP3K5 MEKK5 MAP3K5 6q22.33 Approved MAPKKK5, ASK1 MAP3K5 mitogen-activated protein kinase kinase kinase 5; Component of a protein kinase signal transduction cascade. Phosphorylates and activates MAP2K4 and MAP2K6, which in turn activate the JNK and p38 MAP kinases, respectively. Overexpression induces apoptotic cell death
9064 MAP3K6 9064 HGNC:6858 1552631_a_at
219278_at
229960_at
mitogen-activated protein kinase kinase kinase 6 ENSG00000142733 1p36.11 Approved
6885 MAP3K7 6885 HGNC:6859 Hs.714773 206853_s_at
206854_s_at
211536_x_at
211537_x_at
mitogen-activated protein kinase kinase kinase 7 Mitogen-activated protein kinase kinase kinase 7 ENSG00000135341 ENSP00000358335 MAP3K7 TAK1 MAP3K7 6q15 Approved REACT_6900 MAP3K7 mitogen-activated protein kinase kinase kinase 7; Component of a protein kinase signal transduction cascade. Mediator of TGF-beta signal transduction. Stimulates NF- kappa-B activation and the p38 MAPK pathway
1326 MAP3K8 1326 HGNC:6860 205027_s_at
235421_at
mitogen-activated protein kinase kinase kinase 8 ENSG00000107968 COT, ESTF 10p11.2 Approved
4293 MAP3K9 4293 HGNC:6861 213927_at
214969_at
mitogen-activated protein kinase kinase kinase 9 ENSG00000006432 MLK1 14q24.2 Approved
1432 MAPK14 1432 HGNC:6876 Hs.588289 202530_at
210449_x_at
211087_x_at
211561_x_at
mitogen-activated protein kinase 14 Mitogen-activated protein kinase 14 ENSG00000112062 ENSP00000229794 MAPK14 CSPB1, CSBP1, CSBP2 MAPK14 6p21.3-p21.2 Approved PRKM14, p38, Mxi2, PRKM15 Mxi2 mitogen-activated protein kinase 14; Responds to activation by environmental stress, pro- inflammatory cytokines and lipopolysaccharide (LPS) by phosphorylating a number of transcription factors, such as ELK1 and ATF2 and several downstream kinases, such as MAPKAPK2 and MAPKAPK5. Plays a critical role in the production of some cytokines, for example IL-6. May play a role in stabilization of EPO mRNA during hypoxic stress. Isoform Mxi2 activation is stimulated by mitogens and oxidative stress and only poorly phosphorylates ELK1 and ATF2. Isoform Exip may play a role in the early onset o [...]
4790 NFKB1 4790 HGNC:7794 Hs.654408 209239_at
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 Nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 ENSG00000109320 ENSP00000226574 hsa+4790 NFKB1 NFKB1 4q24 Approved REACT_6900 KBF1, p105, NFKB-p50, p50, NF-kappabeta KBF1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1; NF-kappa-B is a pleiotropic transcription factor which is present in almost all cell types and is involved in many biological processed such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. NF- kappa-B is a homo- or heterodimeric complex formed by the Rel-like domain-containing proteins RELA/p65, RELB, NFKB1/p105, NFKB1/p50, REL and NFKB2/p52 and the heterodimeric p65-p50 complex appears to be most abundant one. The dimers bind at kappa-B sites in the DNA of their target genes and [...]
4791 NFKB2 4791 HGNC:7795 Hs.73090 207535_s_at
209636_at
211524_at
nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100) Nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100) ENSG00000077150 ENSP00000189444 hsa+4791 NFKB2 NFKB2 10q24 Approved LYT-10 NFKB2 nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100); NF-kappa-B is a pleiotropic transcription factor which is present in almost all cell types and is involved in many biological processed such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. NF- kappa-B is a homo- or heterodimeric complex formed by the Rel-like domain-containing proteins RELA/p65, RELB, NFKB1/p105, NFKB1/p50, REL and NFKB2/p52. The dimers bind at kappa-B sites in the DNA of their target genes and the individual dimers have distinct preferences for differ [...]
4792 NFKBIA 4792 HGNC:7797 Hs.81328 201502_s_at
nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha Nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha ENSG00000100906 ENSP00000216797 hsa+4792 NFKBIA NFKBI NFKBIA 14q13 Approved REACT_6900 IKBA, MAD-3, IkappaBalpha IKBA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha; Inhibits the activity of dimeric NF-kappa-B/REL complexes by trapping REL dimers in the cytoplasm through masking of their nuclear localization signals. On cellular stimulation by immune and proinflammatory responses, becomes phosphorylated promoting ubiquitination and degradation, enabling the dimeric RELA to tranlocate to the nucleus and activate transcription
5290 PIK3CA 5290 HGNC:8975 Hs.553498 Hs.85701 204369_at
231854_at
235980_at
phosphoinositide-3-kinase, catalytic, alpha polypeptide Phosphoinositide-3-kinase, catalytic, alpha polypeptide ENSG00000121879 ENSP00000263967 hsa+5290 PIK3CA PIK3CA 3q26.3 Approved REACT_498 PIK3CA phosphoinositide-3-kinase, catalytic, alpha polypeptide; Phosphorylates PtdIns, PtdIns4P and PtdIns(4,5)P2 with a preference for PtdIns(4,5)P2
5578 PRKCA 5578 HGNC:9393 1560074_at
206923_at
213093_at
215194_at
215195_at
protein kinase C, alpha PKCA 17q22-q24 Approved
5970 RELA 5970 HGNC:9955 Hs.502875 201783_s_at
209878_s_at
230202_at
v-rel reticuloendotheliosis viral oncogene homolog A (avian) V-rel reticuloendotheliosis viral oncogene homolog A (avian) GO:0006916 ENSG00000173039 ENSP00000384273 hsa+5970 RELA NFKB3 RELA IDA 11q13 Approved REACT_6900 p65 RELA v-rel reticuloendotheliosis viral oncogene homolog A (avian); NF-kappa-B is a pleiotropic transcription factor which is present in almost all cell types and is involved in many biological processed such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. NF- kappa-B is a homo- or heterodimeric complex formed by the Rel-like domain-containing proteins RELA/p65, RELB, NFKB1/p105, NFKB1/p50, REL and NFKB2/p52 and the heterodimeric p65-p50 complex appears to be most abundant one. The dimers bind at kappa-B sites in the DNA of their target genes and the ind [...]
5971 RELB 5971 HGNC:9956 205205_at
v-rel avian reticuloendotheliosis viral oncogene homolog B ENSG00000104856 19q13.32 Approved
8767 RIPK2 8767 HGNC:10020 209544_at
209545_s_at
receptor-interacting serine-threonine kinase 2 ENSG00000104312 8q21 Approved
6714 SRC 6714 HGNC:11283 1558210_at
1558211_s_at
1565080_at
1565082_x_at
213324_at
221281_at
221284_s_at
v-src avian sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog ENSG00000197122 SRC1 20q12-q13 Approved
6850 SYK 6850 HGNC:11491 207540_s_at
209269_s_at
226068_at
244023_at
spleen tyrosine kinase ENSG00000165025 9q22 Approved
7128 TNFAIP3 7128 HGNC:11896 202643_s_at
202644_s_at
tumor necrosis factor, alpha-induced protein 3 ENSG00000118503 ENSP00000237289 TNFAIP3 6q23-q25 Approved A20, OTUD7C tumor necrosis factor, alpha-induced protein 3; Essential component of a ubiquitin-editing protein complex, comprising also RNF11, ITCH and TAX1BP1, that ensures the transient nature of inflammatory signaling pathways. Upon TNF stimulation, deubiquitinates 'Lys-63'-polyubiquitin chains on RIPK1 and catalyzes the formation of 'Lys-48'-polyubiquitin chains. This leads to RIPK1 proteosomal degradation and consequently termination of the TNF- or LPS-mediated activation of NF-kappa-B. In vitro able to deubiquitinate both 'Lys-48'- and 'Lys-63' polyubiquitin chains. Inhibitor of programmed c [...]
36 genes found.

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ID ApprovedSymbol EntrezGene HGNC
UniGeneID HugoName UniGeneName GeneOntologyID
ENSG ENSP KEGGID ApprovedSymbol2
PreviousSymbols NCIName Evidence Chromosome
Status Reactome_ID Aliases StringSymbol
StringName Affymetrics


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