NAME: SASP

ID ApprovedSymbol EntrezGene HGNC UniGeneID Affymetrics HugoName UniGeneName GeneOntologyID ENSG ENSP KEGGID ApprovedSymbol2 PreviousSymbols NCIName Evidence Chromosome Status Reactome_ID Aliases StringSymbol StringName
640 BLK 640 HGNC:1057 206255_at
210934_at
B lymphoid tyrosine kinase ENSG00000136573 8p23-p22 Approved
1843 DUSP1 1843 HGNC:3064 201041_s_at
201044_x_at
226578_s_at
dual specificity phosphatase 1 ENSG00000120129 PTPN10 5q35.1 Approved
11221 DUSP10 11221 HGNC:3065 215501_s_at
221563_at
dual specificity phosphatase 10 ENSG00000143507 1q41 Approved
80824 DUSP16 80824 HGNC:17909 1555399_a_at
1563505_at
224336_s_at
224832_at
dual specificity phosphatase 16 12p13 Approved
1850 DUSP8 1850 HGNC:3074 206374_at
238594_x_at
dual specificity phosphatase 8 ENSG00000184545 C11orf81 11p15.5 Approved
2268 FGR 2268 HGNC:3697 208438_s_at
feline Gardner-Rasheed sarcoma viral oncogene homolog ENSG00000000938 SRC2 1p36.2-p36.1 Approved
2534 FYN 2534 HGNC:4037 1559101_at
210105_s_at
212486_s_at
216033_s_at
FYN oncogene related to SRC, FGR, YES ENSG00000010810 6q21 Approved
3055 HCK 3055 HGNC:4840 208018_s_at
hemopoietic cell kinase ENSG00000101336 20q11-q12 Approved
3664 IRF6 3664 HGNC:6121 1552477_a_at
1552478_a_at
202597_at
interferon regulatory factor 6 ENSG00000117595 VWS, LPS 1q32.2-q32.3 Approved
3932 LCK 3932 HGNC:6524 204890_s_at
204891_s_at
lymphocyte-specific protein tyrosine kinase ENSG00000182866 1p34.3 Approved
4067 LYN 4067 HGNC:6735 202625_at
202626_s_at
210754_s_at
v-yes-1 Yamaguchi sarcoma viral related oncogene homolog ENSG00000254087 8q13 Approved
5606 MAP2K3 5606 HGNC:6843 Hs.514012 207667_s_at
215498_s_at
215499_at
mitogen-activated protein kinase kinase 3 Mitogen-activated protein kinase kinase 3 ENSG00000034152 ENSP00000345083 MAP2K3 PRKMK3 MAP2K3 17q11.2 Approved MEK3, MKK3, MAPKK3 MEK3 mitogen-activated protein kinase kinase 3; Dual specificity kinase. Is activated by cytokines and environmental stress in vivo. Catalyzes the concomitant phosphorylation of a threonine and a tyrosine residue in the MAP kinase p38
6416 MAP2K4 6416 HGNC:6844 Hs.514681 203265_s_at
203266_s_at
mitogen-activated protein kinase kinase 4 Mitogen-activated protein kinase kinase 4 ENSG00000065559 ENSP00000262445 MAP2K4 SERK1 MAP2K4 17p11.2 Approved MEK4, JNKK1, PRKMK4, MKK4 MKK4 mitogen-activated protein kinase kinase 4; Dual specificity kinase that activates the JUN kinases MAPK8 (JNK1) and MAPK9 (JNK2) as well as MAPK14 (p38) but not MAPK1 (ERK2) or MAPK3 (ERK1)
5608 MAP2K6 5608 HGNC:6846 205698_s_at
205699_at
mitogen-activated protein kinase kinase 6 MAP2K6 PRKMK6 17q Approved
7786 MAP3K12 7786 HGNC:6851 205447_s_at
205448_s_at
mitogen-activated protein kinase kinase kinase 12 ENSG00000139625 ZPK 12q13.13 Approved
4215 MAP3K3 4215 HGNC:6855 203514_at
227131_at
243505_at
mitogen-activated protein kinase kinase kinase 3 ENSP00000354927 MAP3K3 MEKK3 17q Approved MAPKKK3 mitogen-activated protein kinase kinase kinase 3; Component of a protein kinase signal transduction cascade. Mediates activation of the NF-kappa-B, AP1 and DDIT3 transcriptional regulators
5600 MAPK11 5600 HGNC:6873 206040_s_at
211499_s_at
211500_at
mitogen-activated protein kinase 11 ENSG00000185386 MAPK11 PRKM11 22q13.33 Approved
1432 MAPK14 1432 HGNC:6876 Hs.588289 202530_at
210449_x_at
211087_x_at
211561_x_at
mitogen-activated protein kinase 14 Mitogen-activated protein kinase 14 ENSG00000112062 ENSP00000229794 MAPK14 CSPB1, CSBP1, CSBP2 MAPK14 6p21.3-p21.2 Approved PRKM14, p38, Mxi2, PRKM15 Mxi2 mitogen-activated protein kinase 14; Responds to activation by environmental stress, pro- inflammatory cytokines and lipopolysaccharide (LPS) by phosphorylating a number of transcription factors, such as ELK1 and ATF2 and several downstream kinases, such as MAPKAPK2 and MAPKAPK5. Plays a critical role in the production of some cytokines, for example IL-6. May play a role in stabilization of EPO mRNA during hypoxic stress. Isoform Mxi2 activation is stimulated by mitogens and oxidative stress and only poorly phosphorylates ELK1 and ATF2. Isoform Exip may play a role in the early onset o [...]
5058 PAK1 5058 HGNC:8590 1565772_at
209615_s_at
226507_at
230100_x_at
p21 protein (Cdc42/Rac)-activated kinase 1 11q13-q14 Approved
5062 PAK2 5062 HGNC:8591 Hs.518530 1559052_s_at
205962_at
208875_s_at
208876_s_at
208877_at
208878_s_at
p21 protein (Cdc42/Rac)-activated kinase 2 P21 protein (Cdc42/Rac)-activated kinase 2 ENSG00000180370 ENSP00000314067 PAK2 PAK2 3q29 Approved REACT_6185 PAK65, PAKgamma PAK2 p21 protein (Cdc42/Rac)-activated kinase 2; The activated kinase acts on a variety of targets. Phosphorylates ribosomal protein S6, histone H4 and myelin basic protein. Full length PAK 2 stimulates cell survival and cell growth. The process is, at least in part, mediated by phosphorylation and inhibition of pro-apoptotic BAD. Caspase- activated PAK-2p34 is involved in cell death response, probably involving the JNK signaling pathway. Cleaved PAK-2p34 seems to have a higher activity than the CDC42-activated form
5063 PAK3 5063 HGNC:8592 214607_at
p21 protein (Cdc42/Rac)-activated kinase 3 ENSG00000077264 MRX30, MRX47 Xq22.3 Approved
8737 RIPK1 8737 HGNC:10019 Hs.519842 209941_at
226551_at
receptor (TNFRSF)-interacting serine-threonine kinase 1 Receptor (TNFRSF)-interacting serine-threonine kinase 1 GO:0008633 ENSG00000137275 ENSP00000259808 hsa+8737 RIPK1 RIPK1 EXP 6p25.2 Approved REACT_578 REACT_6900 RIP RIPK1 receptor (TNFRSF)-interacting serine-threonine kinase 1; Involved in the transduction of TNF signaling. TNF stimulation induces binding of RIPK1-TRADD-TRAF2-TRAF5 complex to TNFR1. TRAF proteins then catalyze the 'Lys-63'-linked polyubiquitination of RIPK1, inducing RIPK1 association with the IKK complex, which is subsequently activated, leading ultimately to the activation of NF-kappa-B. The inflammatory response is kept transient by the action of the NF-kappa-B target gene product TNFAIP3. TNFAIP3 is recruited to RIPK1 within a complex comprising also RNF11, ITCH and TAX1BP1. TNFAIP3 [...]
6714 SRC 6714 HGNC:11283 1558210_at
1558211_s_at
1565080_at
1565082_x_at
213324_at
221281_at
221284_s_at
v-src avian sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog ENSG00000197122 SRC1 20q12-q13 Approved
10454 TAB1 10454 HGNC:18157 Hs.507681 203901_at
233679_at
235480_at
235827_at
mitogen-activated protein kinase kinase kinase 7 interacting protein 1 Mitogen-activated protein kinase kinase kinase 7 interacting protein 1 ENSG00000100324 ENSP00000216160 MAP3K7IP1 MAP3K7IP1 MAP3K7IP1 22q13.1 Approved REACT_6900 TAB1 TAB1 mitogen-activated protein kinase kinase kinase 7 interacting protein 1; May be an important signaling intermediate between TGFB receptors and MAP3K7/TAK1. May play an important role in mammalian embryogenesis
7189 TRAF6 7189 HGNC:12036 205558_at
TNF receptor-associated factor 6 TRAF6 11p12 Approved
7525 YES1 7525 HGNC:12841 202932_at
202933_s_at
210917_at
v-yes-1 Yamaguchi sarcoma viral oncogene homolog 1 ENSG00000176105 18p11.31-p11.21 Approved
26 genes found.

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ID ApprovedSymbol EntrezGene HGNC
UniGeneID HugoName UniGeneName GeneOntologyID
ENSG ENSP KEGGID ApprovedSymbol2
PreviousSymbols NCIName Evidence Chromosome
Status Reactome_ID Aliases StringSymbol
StringName Affymetrics


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