NAME: TGF

ID ApprovedSymbol EntrezGene HGNC UniGeneID Affymetrics HugoName UniGeneName GeneOntologyID ENSG ENSP KEGGID ApprovedSymbol2 PreviousSymbols NCIName Evidence Chromosome Status Reactome_ID Aliases StringSymbol StringName
207 AKT1 207 HGNC:391 Hs.525622 207163_s_at
v-akt murine thymoma viral oncogene homolog 1 V-akt murine thymoma viral oncogene homolog 1 GO:0006924 GO:0008633 ENSG00000142208 ENSP00000270202 hsa+207 AKT1 AKT1 EXP IMP 14q32.32-q32.33 Approved REACT_578 RAC, PKB, PRKBA, AKT AKT1 v-akt murine thymoma viral oncogene homolog 1; General protein kinase capable of phosphorylating several known proteins. Phosphorylates TBC1D4. Signals downstream of phosphatidylinositol 3-kinase (PI(3)K) to mediate the effects of various growth factors such as platelet-derived growth factor (PDGF), epidermal growth factor (EGF), insulin and insulin-like growth factor I (IGF-I). Plays a role in glucose transport by mediating insulin-induced translocation of the GLUT4 glucose transporter to the cell surface. Mediates the antiapoptotic effects of IGF-I. Mediates insulin-stimulated protei [...]
324 APC 324 HGNC:583 Hs.158932 203525_s_at
203526_s_at
203527_s_at
215310_at
216933_x_at
adenomatous polyposis coli Adenomatous polyposis coli ENSG00000134982 ENSP00000257430 APC APC 5q21-q22 Approved REACT_11045 DP2, DP3, DP2.5 DP2 adenomatous polyposis coli; Tumor suppressor. Promotes rapid degradation of CTNNB1 and participates in Wnt signaling as a negative regulator. APC activity is correlated with its phosphorylation state
472 ATM 472 HGNC:795 Hs.367437 1553387_at
1554631_at
1570352_at
208442_s_at
210858_x_at
212672_at
ataxia telangiectasia mutated Ataxia telangiectasia mutated ENSG00000149311 ENSP00000278616 hsa+472 ATM ATA, ATDC, ATC, ATD ATM 11q22-q23 Approved TEL1, TELO1 ATM ataxia telangiectasia mutated; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]-Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also involved in signal transduction and cell cycle control. May function as a tumor suppressor. Necessary for activation of ABL1 and SAPK. Phosphorylate [...]
545 ATR 545 HGNC:882 Hs.271791 209902_at
209903_s_at
233288_at
ataxia telangiectasia and Rad3 related Ataxia telangiectasia and Rad3 related ENSG00000175054 ENSP00000343741 hsa+545 ATR ATR 3q22-q24 Approved FRP1, SCKL, SCKL1, MEC1 ENSG00000175054 ataxia telangiectasia and Rad3 related; Serine/threonine protein kinase which activates checkpoint signaling upon genotoxic stresses such as ionizing radiation (IR), ultraviolet light (UV), or DNA replication stalling, thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]-Q. Phosphorylates BRCA1, CHEK1, MCM2, RAD17, RPA2, SMC1 and TP53/p53, which collectively inhibit DNA replication and mitosis and promote DNA repair, recombination and apoptosis. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at sites of DNA damage, thereby regulating DNA damag [...]
8312 AXIN1 8312 HGNC:903 212849_at
axin 1 ENSG00000103126 16p13.3 Approved
581 BAX 581 HGNC:959 Hs.631546 208478_s_at
211833_s_at
BCL2-associated X protein BCL2-associated X protein GO:0006917 GO:0006919 GO:0043525 ENSG00000087088 ENSP00000293288 hsa+581 BAX BAX IDA 19q13.3-q13.4 Approved REACT_578 BCL2L4 BAX BCL2-associated X protein; Accelerates programmed cell death by binding to, and antagonizing the apoptosis repressor BCL2 or its adenovirus homolog E1B 19k protein. Induces the release of cytochrome c, activation of CASP3, and thereby apoptosis
596 BCL2 596 HGNC:990 Hs.150749 203684_s_at
203685_at
207004_at
207005_s_at
B-cell CLL/lymphoma 2 B-cell CLL/lymphoma 2 GO:0006916 GO:0008633 ENSG00000171791 ENSP00000329623 hsa+596 BCL2 BCL2 EXP IDA 18q21.3 Approved REACT_578 Bcl-2 BCL2 B-cell CLL/lymphoma 2; Suppresses apoptosis in a variety of cell systems including factor-dependent lymphohematopoietic and neural cells. Regulates cell death by controlling the mitochondrial membrane permeability. Appears to function in a feedback loop system with caspases. Inhibits caspase activity either by preventing the release of cytochrome c from the mitochondria and/or by binding to the apoptosis-activating factor (APAF-1)
329 BIRC2 329 HGNC:590 Hs.696238 202076_at
baculoviral IAP repeat-containing 2 Baculoviral IAP repeat-containing 2 ENSG00000110330 ENSP00000227758 hsa+329 BIRC2 API1 BIRC2 11q22 Approved cIAP1, hiap-2, MIHB, RNF48 MIHB baculoviral IAP repeat-containing 2; Apoptotic suppressor. The BIR motifs region interacts with TNF receptor associated factors 1 and 2 (TRAF1 and TRAF2) to form an heteromeric complex, which is then recruited to the tumor necrosis factor receptor 2 (TNFR2)
330 BIRC3 330 HGNC:591 Hs.127799 210538_s_at
baculoviral IAP repeat-containing 3 Baculoviral IAP repeat-containing 3 ENSG00000023445 ENSP00000263464 hsa+330 BIRC3 API2 BIRC3 11q22 Approved cIAP2, hiap-1, MIHC, RNF49, MALT2 API2 baculoviral IAP repeat-containing 3; Apoptotic suppressor. The BIR motifs region interacts with TNF receptor associated factors 1 and 2 (TRAF1 and TRAF2) to form an heteromeric complex, which is then recruited to the tumor necrosis factor receptor 2 (TNFR2)
841 CASP8 841 HGNC:1509 Hs.599762 1553306_at
207686_s_at
213373_s_at
caspase 8, apoptosis-related cysteine peptidase Caspase 8, apoptosis-related cysteine peptidase GO:0008624 GO:0008633 ENSG00000064012 ENSP00000351273 hsa+841 CASP8 CASP8 EXP 2q33-q34 Approved REACT_578 MCH5, MACH, FLICE, Casp-8 MCH5 caspase 8, apoptosis-related cysteine peptidase; Most upstream protease of the activation cascade of caspases responsible for the TNFRSF6/FAS mediated and TNFRSF1A induced cell death. Binding to the adapter molecule FADD recruits it to either receptor. The resulting aggregate called death- inducing signaling complex (DISC) performs CASP8 proteolytic activation. The active dimeric enzyme is then liberated from the DISC and free to activate downstream apoptotic proteases. Proteolytic fragments of the N-terminal propeptide (termed CAP3, CAP5 and CAP6) are likely retained in the DISC. Clea [...]
1026 CDKN1A 1026 HGNC:1784 Hs.370771 1555186_at
202284_s_at
cyclin-dependent kinase inhibitor 1A (p21, Cip1) Cyclin-dependent kinase inhibitor 1A (p21, Cip1) ENSG00000124762 ENSP00000244741 hsa+1026 CDKN1A CDKN1 CDKN1A 6p21.1 Approved P21, CIP1, WAF1, SDI1, CAP20, p21CIP1, p21Cip1/Waf1 CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1); May be the important intermediate by which p53 mediates its role as an inhibitor of cellular proliferation in response to DNA damage. Binds to and inhibits cyclin-dependent kinase activity, preventing phosphorylation of critical cyclin-dependent kinase substrates and blocking cell cycle progression
1029 CDKN2A 1029 HGNC:1787 Hs.512599 207039_at
209644_x_at
211156_at
cyclin-dependent kinase inhibitor 2A (melanoma, p16, inhibits CDK4) Cyclin-dependent kinase inhibitor 2A (melanoma, p16, inhibits CDK4) GO:0006309 GO:0006917 GO:0006919 GO:0008637 ENSG00000147889 ENSP00000355153 hsa+1029 CDKN2A CDKN2, MLM CDKN2A IDA IMP 9p21 Approved CDK4I, p16, INK4a, MTS1, CMM2, ARF, p19, p14, INK4, p16INK4a CDKN2A cyclin-dependent kinase inhibitor 2A (melanoma, p16, inhibits CDK4); Capable of inducing cell cycle arrest in G1 and G2 phases. Acts as a tumor suppressor. Binds to MDM2 and blocks its nucleocytoplasmic shuttling by sequestering it in the nucleolus. This inhibits the oncogenic action of MDM2 by blocking MDM2- induced degradation of p53 and enhancing p53-dependent transactivation and apoptosis. Also induces G2 arrest and apoptosis in a p53-independent manner by preventing the activation of cyclin B1/CDC2 complexes. Binds to BCL6 and down-regulates BCL6-induced transcriptional repression [...]
1050 CEBPA 1050 HGNC:1833 204039_at
CCAAT/enhancer binding protein (C/EBP), alpha CEBP 19q13.1 Approved
1111 CHEK1 1111 HGNC:1925 Hs.24529 205393_s_at
205394_at
CHK1 checkpoint homolog (S. pombe) CHK1 checkpoint homolog (S. pombe) ENSG00000149554 ENSP00000278916 hsa+1111 CHEK1 CHEK1 11q24.2 Approved CHK1 CHEK1 CHK1 checkpoint homolog (S. pombe); Required for checkpoint mediated cell cycle arrest in response to DNA damage or the presence of unreplicated DNA. May also negatively regulate cell cycle progression during unperturbed cell cycles. Recognizes the substrate consensus sequence [R-X-X- S/T]. Binds to and phosphorylates CDC25A, CDC25B and CDC25C. Phosphorylation of CDC25A at 'Ser-178' and 'Thr-507' and phosphorylation of CDC25C at 'Ser-216' creates binding sites for 14-3-3 proteins which inhibit CDC25A and CDC25C. Phosphorylation of CDC25A at 'Ser-76', 'Ser-124', 'Ser-178', 'Ser-279' and [...]
11200 CHEK2 11200 HGNC:16627 Hs.291363 210416_s_at
CHK2 checkpoint homolog (S. pombe) CHK2 checkpoint homolog (S. pombe) GO:0008630 ENSG00000183765 ENSP00000372023 hsa+11200 CHEK2 RAD53 CHEK2 IDA 22q12.1 Approved REACT_1538 CDS1, CHK2, HuCds1, PP1425, bA444G7 CHK2 CHK2 checkpoint homolog (S. pombe); Regulates cell cycle checkpoints and apoptosis in response to DNA damage, particularly to DNA double-strand breaks. Inhibits CDC25C phosphatase by phosphorylation on 'Ser-216', preventing the entry into mitosis. May also play a role in meiosis. Regulates the TP53 tumor suppressor through phosphorylation at 'Thr-18' and 'Ser-20'
23373 CRTC1 23373 HGNC:16062 207159_x_at
213091_at
CREB regulated transcription coactivator 1 MECT1 19p13 Approved
200186 CRTC2 200186 HGNC:27301 226307_at
CREB regulated transcription coactivator 2 ENSG00000160741 1q21.3 Approved
1499 CTNNB1 1499 HGNC:2514 Hs.476018 1554411_at
201533_at
223679_at
catenin (cadherin-associated protein), beta 1, 88kDa Catenin (cadherin-associated protein), beta 1, 88kDa ENSG00000168036 ENSP00000344456 CTNNB1 CTNNB CTNNB1 3p21 Approved REACT_11045 CTNNB catenin (cadherin-associated protein), beta 1, 88kDa; Involved in the regulation of cell adhesion and in signal transduction through the Wnt pathway
23586 DDX58 23586 HGNC:19102 218943_s_at
222793_at
242961_x_at
DEAD (Asp-Glu-Ala-Asp) box polypeptide 58 ENSG00000107201 9p12 Approved
1786 DNMT1 1786 HGNC:2976 201697_s_at
DNA (cytosine-5-)-methyltransferase 1 DNMT1 DNMT 19p13.2 Approved
1789 DNMT3B 1789 HGNC:2979 220668_s_at
DNA (cytosine-5-)-methyltransferase 3 beta ENSG00000088305 20q11.2 Approved
1855 DVL1 1855 HGNC:3084 203230_at
dishevelled segment polarity protein 1 ENSG00000107404 1p36 Approved
2932 GSK3B 2932 HGNC:4617 Hs.445733 209945_s_at
226183_at
226191_at
240562_at
242336_at
glycogen synthase kinase 3 beta Glycogen synthase kinase 3 beta GO:0043066 ENSG00000082701 ENSP00000324806 hsa+2932 GSK3B GSK3B IDA 3q13.3 Approved REACT_11045 GSK3B glycogen synthase kinase 3 beta; Participates in the Wnt signaling pathway. Implicated in the hormonal control of several regulatory proteins including glycogen synthase, MYB and the transcription factor JUN. Phosphorylates JUN at sites proximal to its DNA-binding domain, thereby reducing its affinity for DNA. Phosphorylates MUC1 in breast cancer cells, and decreases the interaction of MUC1 with CTNNB1/beta-catenin. Phosphorylates CTNNB1/beta-catenin
3265 HRAS 3265 HGNC:5173 Hs.37003 212983_at
v-Ha-ras Harvey rat sarcoma viral oncogene homolog V-Ha-ras Harvey rat sarcoma viral oncogene homolog ENSG00000174775 ENSP00000309845 HRAS HRAS1 HRAS 11p15.5 Approved REACT_498 HRAS v-Ha-ras Harvey rat sarcoma viral oncogene homolog; Ras proteins bind GDP/GTP and possess intrinsic GTPase activity
3551 IKBKB 3551 HGNC:5960 Hs.656458 209341_s_at
209342_s_at
211027_s_at
inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta Inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta ENSG00000104365 ENSP00000339151 hsa+3551 IKBKB IKBKB 8p11.2 Approved REACT_6900 IKK2, NFKBIKB, IKK-beta, IKKB IKKB inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta; Acts as part of the IKK complex in the conventional pathway of NF-kappa-B activation and phosphorylates inhibitors of NF-kappa-B thus leading to the dissociation of the inhibitor/NF- kappa-B complex and ultimately the degradation of the inhibitor. Also phosphorylates NCOA3
8517 IKBKG 8517 HGNC:5961 Hs.43505 209929_s_at
36004_at
inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma Inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma ENSG00000073009 ENSP00000358622 hsa+8517 IKBKG IP2, IP1 IKBKG Xq28 Approved REACT_6900 IKK-gamma, NEMO, Fip3p, FIP-3, FIP3 IKBKG inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma; Regulatory subunit of the IKK core complex which phosphorylates inhibitors of NF-kappa-B thus leading to the dissociation of the inhibitor/NF-kappa-B complex and ultimately the degradation of the inhibitor. Also considered to be a mediator for TAX activation of NF-kappa-B. Could be implicated in NF-kappa- B-mediated protection from cytokine toxicity (By similarity)
3552 IL1A 3552 HGNC:5991 Hs.1722 208200_at
210118_s_at
interleukin 1, alpha Interleukin 1, alpha ENSG00000115008 ENSP00000263339 hsa+3552 IL1A IL1 IL1A 2q14 Approved IL1F1, IL-1A IL1 interleukin 1, alpha; Produced by activated macrophages, IL-1 stimulates thymocyte proliferation by inducing IL-2 release, B-cell maturation and proliferation, and fibroblast growth factor activity. IL-1 proteins are involved in the inflammatory response, being identified as endogenous pyrogens, and are reported to stimulate the release of prostaglandin and collagenase from synovial cells (By similarity)
3569 IL6 3569 HGNC:6018 205207_at
interleukin 6 ENSG00000136244 IFNB2 7p21-p15 Approved
9365 KL 9365 HGNC:6344 205978_at
klotho ENSG00000133116 13q12 Approved
3845 KRAS 3845 HGNC:6407 1559203_s_at
1559204_x_at
204009_s_at
204010_s_at
214352_s_at
Kirsten rat sarcoma viral oncogene homolog ENSG00000133703 KRAS2 12p12.1 Approved
6885 MAP3K7 6885 HGNC:6859 Hs.714773 206853_s_at
206854_s_at
211536_x_at
211537_x_at
mitogen-activated protein kinase kinase kinase 7 Mitogen-activated protein kinase kinase kinase 7 ENSG00000135341 ENSP00000358335 MAP3K7 TAK1 MAP3K7 6q15 Approved REACT_6900 MAP3K7 mitogen-activated protein kinase kinase kinase 7; Component of a protein kinase signal transduction cascade. Mediator of TGF-beta signal transduction. Stimulates NF- kappa-B activation and the p38 MAPK pathway
5602 MAPK10 5602 HGNC:6872 204813_at
237413_at
mitogen-activated protein kinase 10 ENSG00000109339 PRKM10 4q22-q23 Approved
1432 MAPK14 1432 HGNC:6876 Hs.588289 202530_at
210449_x_at
211087_x_at
211561_x_at
mitogen-activated protein kinase 14 Mitogen-activated protein kinase 14 ENSG00000112062 ENSP00000229794 MAPK14 CSPB1, CSBP1, CSBP2 MAPK14 6p21.3-p21.2 Approved PRKM14, p38, Mxi2, PRKM15 Mxi2 mitogen-activated protein kinase 14; Responds to activation by environmental stress, pro- inflammatory cytokines and lipopolysaccharide (LPS) by phosphorylating a number of transcription factors, such as ELK1 and ATF2 and several downstream kinases, such as MAPKAPK2 and MAPKAPK5. Plays a critical role in the production of some cytokines, for example IL-6. May play a role in stabilization of EPO mRNA during hypoxic stress. Isoform Mxi2 activation is stimulated by mitogens and oxidative stress and only poorly phosphorylates ELK1 and ATF2. Isoform Exip may play a role in the early onset o [...]
4193 MDM2 4193 HGNC:6973 Hs.567303 205385_at
205386_s_at
211832_s_at
217373_x_at
217542_at
225160_x_at
229711_s_at
237891_at
244616_x_at
Mdm2 p53 binding protein homolog (mouse) Mdm2 p53 binding protein homolog (mouse) ENSG00000135679 ENSP00000417281 hsa+4193 MDM2 MDM2 12q13-q14 Approved HDM2, HDMX HDM2 Mdm2 p53 binding protein homolog (mouse); Inhibits TP53/p53- and TP73/p73-mediated cell cycle arrest and apoptosis by binding its transcriptional activation domain. Functions as a ubiquitin ligase E3, in the presence of E1 and E2, toward p53 and itself. Permits the nuclear export of p53 and targets it for proteasome-mediated proteolysis. Functions as an ubiquitin ligase E3 toward ARRB1 (By similarity)
4361 MRE11A 4361 HGNC:7230 Hs.192649 205395_s_at
211334_at
242456_at
MRE11 meiotic recombination 11 homolog A (S. cerevisiae) MRE11 meiotic recombination 11 homolog A (S. cerevisiae) ENSG00000020922 ENSP00000325863 hsa+4361 MRE11A MRE11 MRE11A 11q21 Approved ATLD MRE11A MRE11 meiotic recombination 11 homolog A (S. cerevisiae); Component of the MRN complex, which plays a central role in double-strand break (DSB) repair, DNA recombination, maintenance of telomere integrity and meiosis. The complex possesses single-strand endonuclease activity and double-strand- specific 3'-5' exonuclease activity, which are provided by MRE11A. RAD50 may be required to bind DNA ends and hold them in close proximity. This could facilitate searches for short or long regions of sequence homology in the recombining DNA templates, and may also stimulate the activity of DNA li [...]
2475 MTOR 2475 HGNC:3942 202288_at
215381_at
mechanistic target of rapamycin (serine/threonine kinase) ENSG00000198793 FRAP, FRAP2, FRAP1 1p36 Approved
4609 MYC 4609 HGNC:7553 Hs.202453 202431_s_at
244089_at
v-myc myelocytomatosis viral oncogene homolog (avian) Similar to ORF 114 ENSG00000136997 ENSP00000367207 MYC MYC 8q24 Approved c-Myc, bHLHe39 MYC v-myc myelocytomatosis viral oncogene homolog (avian); Participates in the regulation of gene transcription. Binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Seems to activate the transcription of growth-related genes
4683 NBN 4683 HGNC:7652 Hs.492208 202905_x_at
202906_s_at
202907_s_at
217299_s_at
240510_at
nibrin Nibrin ENSG00000104320 ENSP00000265433 hsa+4683 NBN NBS, NBS1 NBN 8q21-q24 Approved ATV, AT-V2, AT-V1 NBN nibrin; Component of the MRE11/RAD50/NBN (MRN complex) which plays a critical role in the cellular response to DNA damage and the maintenance of chromosome integrity. The complex is involved in double-strand break (DSB) repair, DNA recombination, maintenance of telomere integrity, cell cycle checkpoint control and meiosis. The complex possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity, which are provided by MRE11A. RAD50 may be required to bind DNA ends and hold them in close proximity. NBN modulate the DNA damage signal sensing by recru [...]
4790 NFKB1 4790 HGNC:7794 Hs.654408 209239_at
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 Nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 ENSG00000109320 ENSP00000226574 hsa+4790 NFKB1 NFKB1 4q24 Approved REACT_6900 KBF1, p105, NFKB-p50, p50, NF-kappabeta KBF1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1; NF-kappa-B is a pleiotropic transcription factor which is present in almost all cell types and is involved in many biological processed such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. NF- kappa-B is a homo- or heterodimeric complex formed by the Rel-like domain-containing proteins RELA/p65, RELB, NFKB1/p105, NFKB1/p50, REL and NFKB2/p52 and the heterodimeric p65-p50 complex appears to be most abundant one. The dimers bind at kappa-B sites in the DNA of their target genes and [...]
4791 NFKB2 4791 HGNC:7795 Hs.73090 207535_s_at
209636_at
211524_at
nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100) Nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100) ENSG00000077150 ENSP00000189444 hsa+4791 NFKB2 NFKB2 10q24 Approved LYT-10 NFKB2 nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100); NF-kappa-B is a pleiotropic transcription factor which is present in almost all cell types and is involved in many biological processed such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. NF- kappa-B is a homo- or heterodimeric complex formed by the Rel-like domain-containing proteins RELA/p65, RELB, NFKB1/p105, NFKB1/p50, REL and NFKB2/p52. The dimers bind at kappa-B sites in the DNA of their target genes and the individual dimers have distinct preferences for differ [...]
4792 NFKBIA 4792 HGNC:7797 Hs.81328 201502_s_at
nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha Nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha ENSG00000100906 ENSP00000216797 hsa+4792 NFKBIA NFKBI NFKBIA 14q13 Approved REACT_6900 IKBA, MAD-3, IkappaBalpha IKBA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha; Inhibits the activity of dimeric NF-kappa-B/REL complexes by trapping REL dimers in the cytoplasm through masking of their nuclear localization signals. On cellular stimulation by immune and proinflammatory responses, becomes phosphorylated promoting ubiquitination and degradation, enabling the dimeric RELA to tranlocate to the nucleus and activate transcription
4893 NRAS 4893 HGNC:7989 202647_s_at
224985_at
neuroblastoma RAS viral (v-ras) oncogene homolog ENSG00000213281 1p13.2 Approved
5290 PIK3CA 5290 HGNC:8975 Hs.553498 Hs.85701 204369_at
231854_at
235980_at
phosphoinositide-3-kinase, catalytic, alpha polypeptide Phosphoinositide-3-kinase, catalytic, alpha polypeptide ENSG00000121879 ENSP00000263967 hsa+5290 PIK3CA PIK3CA 3q26.3 Approved REACT_498 PIK3CA phosphoinositide-3-kinase, catalytic, alpha polypeptide; Phosphorylates PtdIns, PtdIns4P and PtdIns(4,5)P2 with a preference for PtdIns(4,5)P2
25913 POT1 25913 HGNC:17284 204353_s_at
204354_at
protection of telomeres 1 homolog (S. pombe) ENSG00000128513 POT1 7q31.33 Approved
8493 PPM1D 8493 HGNC:9277 204566_at
protein phosphatase, Mg2+/Mn2+ dependent, 1D ENSG00000170836 17q23.3 Approved
5732 PTGER2 5732 HGNC:9594 206631_at
prostaglandin E receptor 2 (subtype EP2), 53kDa ENSG00000125384 14q22 Approved
80142 PTGES2 80142 HGNC:17822 218083_at
prostaglandin E synthase 2 ENSG00000148334 C9orf15 9q34.12 Approved
5743 PTGS2 5743 HGNC:9605 1554997_a_at
204748_at
prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) ENSG00000073756 PTGS2 1q25.2-q25.3 Approved
10111 RAD50 10111 HGNC:9816 Hs.655835 208393_s_at
209349_at
RAD50 homolog (S. cerevisiae) RAD50 homolog (S. cerevisiae) ENSG00000113522 ENSP00000265335 hsa+10111 RAD50 RAD50 5q23-q31 Approved hRad50, RAD50-2 RAD50 RAD50 homolog (S. cerevisiae); Component of the MRN complex, which plays a central role in double-strand break (DSB) repair, DNA recombination, maintenance of telomere integrity and meiosis. The complex possesses single-strand endonuclease activity and double-strand- specific 3'-5' exonuclease activity, which are provided by MRE11A. RAD50 may be required to bind DNA ends and hold them in close proximity. This could facilitate searches for short or long regions of sequence homology in the recombining DNA templates, and may also stimulate the activity of DNA ligases and/or restrict the n [...]
5966 REL 5966 HGNC:9954 206035_at
206036_s_at
v-rel avian reticuloendotheliosis viral oncogene homolog ENSG00000162924 2p13-p12 Approved
5970 RELA 5970 HGNC:9955 Hs.502875 201783_s_at
209878_s_at
230202_at
v-rel reticuloendotheliosis viral oncogene homolog A (avian) V-rel reticuloendotheliosis viral oncogene homolog A (avian) GO:0006916 ENSG00000173039 ENSP00000384273 hsa+5970 RELA NFKB3 RELA IDA 11q13 Approved REACT_6900 p65 RELA v-rel reticuloendotheliosis viral oncogene homolog A (avian); NF-kappa-B is a pleiotropic transcription factor which is present in almost all cell types and is involved in many biological processed such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. NF- kappa-B is a homo- or heterodimeric complex formed by the Rel-like domain-containing proteins RELA/p65, RELB, NFKB1/p105, NFKB1/p50, REL and NFKB2/p52 and the heterodimeric p65-p50 complex appears to be most abundant one. The dimers bind at kappa-B sites in the DNA of their target genes and the ind [...]
5971 RELB 5971 HGNC:9956 205205_at
v-rel avian reticuloendotheliosis viral oncogene homolog B ENSG00000104856 19q13.32 Approved
8737 RIPK1 8737 HGNC:10019 Hs.519842 209941_at
226551_at
receptor (TNFRSF)-interacting serine-threonine kinase 1 Receptor (TNFRSF)-interacting serine-threonine kinase 1 GO:0008633 ENSG00000137275 ENSP00000259808 hsa+8737 RIPK1 RIPK1 EXP 6p25.2 Approved REACT_578 REACT_6900 RIP RIPK1 receptor (TNFRSF)-interacting serine-threonine kinase 1; Involved in the transduction of TNF signaling. TNF stimulation induces binding of RIPK1-TRADD-TRAF2-TRAF5 complex to TNFR1. TRAF proteins then catalyze the 'Lys-63'-linked polyubiquitination of RIPK1, inducing RIPK1 association with the IKK complex, which is subsequently activated, leading ultimately to the activation of NF-kappa-B. The inflammatory response is kept transient by the action of the NF-kappa-B target gene product TNFAIP3. TNFAIP3 is recruited to RIPK1 within a complex comprising also RNF11, ITCH and TAX1BP1. TNFAIP3 [...]
6667 SP1 6667 HGNC:11205 Sp1 transcription factor 12q13.1 Approved
7014 TERF2 7014 HGNC:11729 1555183_at
1555185_x_at
203611_at
229790_at
telomeric repeat binding factor 2 ENSG00000132604 ENSP00000254942 TERF2 TRBF2 16q22.1 Approved TRF2 telomeric repeat binding factor 2; Binds the telomeric double-stranded TTAGGG repeat. Protects against end-to-end fusion of chromosomes and plays a role in successful progression through the cell division cycle. Component of the shelterin complex (telosome) that is involved in the regulation of telomere length and protection. Shelterin associates with arrays of double-stranded TTAGGG repeats added by telomerase and protects chromosome ends; without its protective activity, telomeres are no longer hidden from the DNA damage surveillance and chromosome ends are inappropriately processed [...]
54386 TERF2IP 54386 HGNC:19246 201174_s_at
telomeric repeat binding factor 2, interacting protein ENSG00000166848 TERF2IP 16q23.1 Approved
7015 TERT 7015 HGNC:11730 Hs.492203 telomerase reverse transcriptase Telomerase reverse transcriptase ENSG00000164362 ENSP00000309572 TERT TERT 5p15.33 Approved TRT, TP2, TCS1, hEST2, EST2 telomerase reverse transcriptase; Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. It elongates telomeres. It is a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme
7040 TGFB1 7040 HGNC:11766 Hs.645227 203084_at
203085_s_at
transforming growth factor, beta 1 Transforming growth factor, beta 1 GO:0006917 ENSG00000105329 ENSP00000221930 hsa+7040 TGFB1 TGFB, DPD1 TGFB1 IDA 19q13.1 Approved REACT_604 REACT_6167 REACT_6844 CED, TGFbeta CED transforming growth factor, beta 1; Multifunctional protein that controls proliferation, differentiation and other functions in many cell types. Many cells synthesize TGFB1 and have specific receptors for it. It positively and negatively regulates many other growth factors. It plays an important role in bone remodeling as it is a potent stimulator of osteoblastic bone formation, causing chemotaxis, proliferation and differentiation in committed osteoblasts
7124 TNF 7124 HGNC:11892 Hs.241570 207113_s_at
tumor necrosis factor (TNF superfamily, member 2) Tumor necrosis factor (TNF superfamily, member 2) GO:0006916 GO:0006919 GO:0006927 ENSG00000206439 ENSP00000392858 hsa+7124 TNF TNFA TNF IDA 6p21.3 Approved REACT_578 TNFSF2, DIF, TNF-alpha ENSG00000206439 tumor necrosis factor (TNF superfamily, member 2); Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation
7132 TNFRSF1A 7132 HGNC:11916 Hs.279594 207643_s_at
tumor necrosis factor receptor superfamily, member 1A Tumor necrosis factor receptor superfamily, member 1A ENSG00000067182 ENSP00000162749 hsa+7132 TNFRSF1A TNFR1 TNFRSF1A 12p13.2 Approved REACT_578 TNF-R, TNFAR, TNFR60, TNF-R-I, CD120a, TNF-R55 TNFR1 tumor necrosis factor receptor superfamily, member 1A; Receptor for TNFSF2/TNF-alpha and homotrimeric TNFSF1/lymphotoxin-alpha. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate- specific cysteine proteases) mediating apoptosis. Contributes to the induction of non-cytocidal TNF effects including anti-viral state and activation of the acid sphingomyelinase
7157 TP53 7157 HGNC:11998 Hs.654481 201746_at
211300_s_at
tumor protein p53 Tumor protein p53 GO:0006289 GO:0008635 GO:0042771 ENSG00000141510 ENSP00000269305 hsa+7157 TP53 TP53 IDA IMP 17p13.1 Approved REACT_1538 p53, LFS1 P53 tumor protein p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Implicated in Notch signaling cross-over
7472 WNT2 7472 HGNC:12780 205648_at
wingless-type MMTV integration site family member 2 ENSG00000105989 INT1L1 7q31 Approved
331 XIAP 331 HGNC:592 Hs.356076 206536_s_at
206537_at
225858_s_at
225859_at
228363_at
235222_x_at
243026_x_at
X-linked inhibitor of apoptosis X-linked inhibitor of apoptosis ENSG00000101966 ENSP00000347858 hsa+331 XIAP API3, BIRC4 XIAP Xq25 Approved REACT_578 hILP BIRC4 X-linked inhibitor of apoptosis; Apoptotic suppressor. Has E3 ubiquitin-protein ligase activity. Mediates the proteasomal degradation of target proteins, such as caspase-3, SMAC or AIFM1. Inhibitor of caspase-3, -7 and -9. Mediates activation of MAP3K7/TAK1, leading to the activation of NF-kappa-B
63 genes found.

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ID ApprovedSymbol EntrezGene HGNC
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ENSG ENSP KEGGID ApprovedSymbol2
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