NAME: RIG-I

ID ApprovedSymbol EntrezGene HGNC UniGeneID Affymetrics HugoName UniGeneName GeneOntologyID ENSG ENSP KEGGID ApprovedSymbol2 PreviousSymbols NCIName Evidence Chromosome Status Reactome_ID Aliases StringSymbol StringName
1026 CDKN1A 1026 HGNC:1784 Hs.370771 1555186_at
202284_s_at
cyclin-dependent kinase inhibitor 1A (p21, Cip1) Cyclin-dependent kinase inhibitor 1A (p21, Cip1) ENSG00000124762 ENSP00000244741 hsa+1026 CDKN1A CDKN1 CDKN1A 6p21.1 Approved P21, CIP1, WAF1, SDI1, CAP20, p21CIP1, p21Cip1/Waf1 CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1); May be the important intermediate by which p53 mediates its role as an inhibitor of cellular proliferation in response to DNA damage. Binds to and inhibits cyclin-dependent kinase activity, preventing phosphorylation of critical cyclin-dependent kinase substrates and blocking cell cycle progression
1051 CEBPB 1051 HGNC:1834 212501_at
CCAAT/enhancer binding protein (C/EBP), beta ENSG00000172216 TCF5 20q13.1 Approved
1786 DNMT1 1786 HGNC:2976 201697_s_at
DNA (cytosine-5-)-methyltransferase 1 DNMT1 DNMT 19p13.2 Approved
1789 DNMT3B 1789 HGNC:2979 220668_s_at
DNA (cytosine-5-)-methyltransferase 3 beta ENSG00000088305 20q11.2 Approved
26959 HBP1 26959 HGNC:23200 207361_at
209102_s_at
HMG-box transcription factor 1 ENSG00000105856 7q22-q31 Approved
3551 IKBKB 3551 HGNC:5960 Hs.656458 209341_s_at
209342_s_at
211027_s_at
inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta Inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta ENSG00000104365 ENSP00000339151 hsa+3551 IKBKB IKBKB 8p11.2 Approved REACT_6900 IKK2, NFKBIKB, IKK-beta, IKKB IKKB inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta; Acts as part of the IKK complex in the conventional pathway of NF-kappa-B activation and phosphorylates inhibitors of NF-kappa-B thus leading to the dissociation of the inhibitor/NF- kappa-B complex and ultimately the degradation of the inhibitor. Also phosphorylates NCOA3
3552 IL1A 3552 HGNC:5991 Hs.1722 208200_at
210118_s_at
interleukin 1, alpha Interleukin 1, alpha ENSG00000115008 ENSP00000263339 hsa+3552 IL1A IL1 IL1A 2q14 Approved IL1F1, IL-1A IL1 interleukin 1, alpha; Produced by activated macrophages, IL-1 stimulates thymocyte proliferation by inducing IL-2 release, B-cell maturation and proliferation, and fibroblast growth factor activity. IL-1 proteins are involved in the inflammatory response, being identified as endogenous pyrogens, and are reported to stimulate the release of prostaglandin and collagenase from synovial cells (By similarity)
3569 IL6 3569 HGNC:6018 205207_at
interleukin 6 ENSG00000136244 IFNB2 7p21-p15 Approved
6885 MAP3K7 6885 HGNC:6859 Hs.714773 206853_s_at
206854_s_at
211536_x_at
211537_x_at
mitogen-activated protein kinase kinase kinase 7 Mitogen-activated protein kinase kinase kinase 7 ENSG00000135341 ENSP00000358335 MAP3K7 TAK1 MAP3K7 6q15 Approved REACT_6900 MAP3K7 mitogen-activated protein kinase kinase kinase 7; Component of a protein kinase signal transduction cascade. Mediator of TGF-beta signal transduction. Stimulates NF- kappa-B activation and the p38 MAPK pathway
1432 MAPK14 1432 HGNC:6876 Hs.588289 202530_at
210449_x_at
211087_x_at
211561_x_at
mitogen-activated protein kinase 14 Mitogen-activated protein kinase 14 ENSG00000112062 ENSP00000229794 MAPK14 CSPB1, CSBP1, CSBP2 MAPK14 6p21.3-p21.2 Approved PRKM14, p38, Mxi2, PRKM15 Mxi2 mitogen-activated protein kinase 14; Responds to activation by environmental stress, pro- inflammatory cytokines and lipopolysaccharide (LPS) by phosphorylating a number of transcription factors, such as ELK1 and ATF2 and several downstream kinases, such as MAPKAPK2 and MAPKAPK5. Plays a critical role in the production of some cytokines, for example IL-6. May play a role in stabilization of EPO mRNA during hypoxic stress. Isoform Mxi2 activation is stimulated by mitogens and oxidative stress and only poorly phosphorylates ELK1 and ATF2. Isoform Exip may play a role in the early onset o [...]
4609 MYC 4609 HGNC:7553 Hs.202453 202431_s_at
244089_at
v-myc myelocytomatosis viral oncogene homolog (avian) Similar to ORF 114 ENSG00000136997 ENSP00000367207 MYC MYC 8q24 Approved c-Myc, bHLHe39 MYC v-myc myelocytomatosis viral oncogene homolog (avian); Participates in the regulation of gene transcription. Binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Seems to activate the transcription of growth-related genes
4790 NFKB1 4790 HGNC:7794 Hs.654408 209239_at
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 Nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 ENSG00000109320 ENSP00000226574 hsa+4790 NFKB1 NFKB1 4q24 Approved REACT_6900 KBF1, p105, NFKB-p50, p50, NF-kappabeta KBF1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1; NF-kappa-B is a pleiotropic transcription factor which is present in almost all cell types and is involved in many biological processed such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. NF- kappa-B is a homo- or heterodimeric complex formed by the Rel-like domain-containing proteins RELA/p65, RELB, NFKB1/p105, NFKB1/p50, REL and NFKB2/p52 and the heterodimeric p65-p50 complex appears to be most abundant one. The dimers bind at kappa-B sites in the DNA of their target genes and [...]
4791 NFKB2 4791 HGNC:7795 Hs.73090 207535_s_at
209636_at
211524_at
nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100) Nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100) ENSG00000077150 ENSP00000189444 hsa+4791 NFKB2 NFKB2 10q24 Approved LYT-10 NFKB2 nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100); NF-kappa-B is a pleiotropic transcription factor which is present in almost all cell types and is involved in many biological processed such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. NF- kappa-B is a homo- or heterodimeric complex formed by the Rel-like domain-containing proteins RELA/p65, RELB, NFKB1/p105, NFKB1/p50, REL and NFKB2/p52. The dimers bind at kappa-B sites in the DNA of their target genes and the individual dimers have distinct preferences for differ [...]
4792 NFKBIA 4792 HGNC:7797 Hs.81328 201502_s_at
nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha Nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha ENSG00000100906 ENSP00000216797 hsa+4792 NFKBIA NFKBI NFKBIA 14q13 Approved REACT_6900 IKBA, MAD-3, IkappaBalpha IKBA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha; Inhibits the activity of dimeric NF-kappa-B/REL complexes by trapping REL dimers in the cytoplasm through masking of their nuclear localization signals. On cellular stimulation by immune and proinflammatory responses, becomes phosphorylated promoting ubiquitination and degradation, enabling the dimeric RELA to tranlocate to the nucleus and activate transcription
5966 REL 5966 HGNC:9954 206035_at
206036_s_at
v-rel avian reticuloendotheliosis viral oncogene homolog ENSG00000162924 2p13-p12 Approved
5970 RELA 5970 HGNC:9955 Hs.502875 201783_s_at
209878_s_at
230202_at
v-rel reticuloendotheliosis viral oncogene homolog A (avian) V-rel reticuloendotheliosis viral oncogene homolog A (avian) GO:0006916 ENSG00000173039 ENSP00000384273 hsa+5970 RELA NFKB3 RELA IDA 11q13 Approved REACT_6900 p65 RELA v-rel reticuloendotheliosis viral oncogene homolog A (avian); NF-kappa-B is a pleiotropic transcription factor which is present in almost all cell types and is involved in many biological processed such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. NF- kappa-B is a homo- or heterodimeric complex formed by the Rel-like domain-containing proteins RELA/p65, RELB, NFKB1/p105, NFKB1/p50, REL and NFKB2/p52 and the heterodimeric p65-p50 complex appears to be most abundant one. The dimers bind at kappa-B sites in the DNA of their target genes and the ind [...]
5971 RELB 5971 HGNC:9956 205205_at
v-rel avian reticuloendotheliosis viral oncogene homolog B ENSG00000104856 19q13.32 Approved
7015 TERT 7015 HGNC:11730 Hs.492203 telomerase reverse transcriptase Telomerase reverse transcriptase ENSG00000164362 ENSP00000309572 TERT TERT 5p15.33 Approved TRT, TP2, TCS1, hEST2, EST2 telomerase reverse transcriptase; Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. It elongates telomeres. It is a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme
7040 TGFB1 7040 HGNC:11766 Hs.645227 203084_at
203085_s_at
transforming growth factor, beta 1 Transforming growth factor, beta 1 GO:0006917 ENSG00000105329 ENSP00000221930 hsa+7040 TGFB1 TGFB, DPD1 TGFB1 IDA 19q13.1 Approved REACT_604 REACT_6167 REACT_6844 CED, TGFbeta CED transforming growth factor, beta 1; Multifunctional protein that controls proliferation, differentiation and other functions in many cell types. Many cells synthesize TGFB1 and have specific receptors for it. It positively and negatively regulates many other growth factors. It plays an important role in bone remodeling as it is a potent stimulator of osteoblastic bone formation, causing chemotaxis, proliferation and differentiation in committed osteoblasts
19 genes found.

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ID ApprovedSymbol EntrezGene HGNC
UniGeneID HugoName UniGeneName GeneOntologyID
ENSG ENSP KEGGID ApprovedSymbol2
PreviousSymbols NCIName Evidence Chromosome
Status Reactome_ID Aliases StringSymbol
StringName Affymetrics


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