NAME: Cyclins and Cell Cycle Regulation

ID ApprovedSymbol EntrezGene HGNC UniGeneID Affymetrics HugoName UniGeneName GeneOntologyID ENSG ENSP KEGGID ApprovedSymbol2 PreviousSymbols NCIName Evidence Chromosome Status Reactome_ID Aliases StringSymbol StringName
8900 CCNA1 8900 HGNC:1577 Hs.417050 205899_at
cyclin A1 Cyclin A1 ENSG00000133101 ENSP00000255465 hsa+8900 CCNA1 CCNA1 13q12.3-q13 Approved CCNA1 cyclin A1; May be involved in the control of the cell cycle at the G1/S (start) and G2/M (mitosis) transitions. May primarily function in the control of the germline meiotic cell cycle and additionally in the control of mitotic cell cycle in some somatic cells
891 CCNB1 891 HGNC:1579 Hs.23960 214710_s_at
228729_at
cyclin B1 Cyclin B1 ENSG00000134057 ENSP00000256442 hsa+891 CCNB1 CCNB CCNB1 5q12 Approved CCNB1 cyclin B1; Essential for the control of the cell cycle at the G2/M (mitosis) transition
983 CDC2 983 HGNC:1722 Hs.334562 203213_at
203214_x_at
210559_s_at
231534_at
cell division cycle 2, G1 to S and G2 to M Cell division cycle 2, G1 to S and G2 to M GO:0006916 ENSG00000170312 ENSP00000362917 hsa+983 CDC2 CDC2 IDA 10q21.2 Approved REACT_152 REACT_1538 REACT_6850 CDC28A ENSG00000170312 cyclin-dependent kinase 1; Plays a key role in the control of the eukaryotic cell cycle. It is required in higher cells for entry into S-phase and mitosis. p34 is a component of the kinase complex that phosphorylates the repetitive C-terminus of RNA polymerase II
993 CDC25A 993 HGNC:1725 Hs.437705 1555772_a_at
204695_at
204696_s_at
cell division cycle 25 homolog A (S. pombe) Cell division cycle 25 homolog A (S. pombe) ENSG00000164045 ENSP00000303706 hsa+993 CDC25A CDC25A 3p21 Approved CDC25A cell division cycle 25 homolog A (S. pombe); Tyrosine protein phosphatase which functions as a dosage-dependent inducer of mitotic progression. Directly dephosphorylates CDC2 and stimulates its kinase activity. Also dephosphorylates CDK2 in complex with cyclin E, in vitro
1017 CDK2 1017 HGNC:1771 Hs.19192 204252_at
211803_at
211804_s_at
cyclin-dependent kinase 2 Cyclin-dependent kinase 2 ENSG00000123374 ENSP00000266970 hsa+1017 CDK2 CDK2 12q13 Approved CDK2 cyclin-dependent kinase 2; Involved in the control of the cell cycle. Interacts with cyclins A, B1, B3, D, or E. Activity of CDK2 is maximal during S phase and G2
1026 CDKN1A 1026 HGNC:1784 Hs.370771 1555186_at
202284_s_at
cyclin-dependent kinase inhibitor 1A (p21, Cip1) Cyclin-dependent kinase inhibitor 1A (p21, Cip1) ENSG00000124762 ENSP00000244741 hsa+1026 CDKN1A CDKN1 CDKN1A 6p21.1 Approved P21, CIP1, WAF1, SDI1, CAP20, p21CIP1, p21Cip1/Waf1 CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1); May be the important intermediate by which p53 mediates its role as an inhibitor of cellular proliferation in response to DNA damage. Binds to and inhibits cyclin-dependent kinase activity, preventing phosphorylation of critical cyclin-dependent kinase substrates and blocking cell cycle progression
1027 CDKN1B 1027 HGNC:1785 Hs.238990 209112_at
cyclin-dependent kinase inhibitor 1B (p27, Kip1) Cyclin-dependent kinase inhibitor 1B (p27, Kip1) GO:0006917 ENSG00000111276 ENSP00000228872 hsa+1027 CDKN1B CDKN1B IDA 12p13.1-p12 Approved KIP1, P27KIP1 KIP1 cyclin-dependent kinase inhibitor 1B (p27, Kip1); Important regulator of cell cycle progression. Involved in G1 arrest. Potent inhibitor of cyclin E- and cyclin A-CDK2 complexes. Positive regulator of cyclin D-dependent kinases such as CDK4. Regulated by phosphorylation and degradation events
1029 CDKN2A 1029 HGNC:1787 Hs.512599 207039_at
209644_x_at
211156_at
cyclin-dependent kinase inhibitor 2A (melanoma, p16, inhibits CDK4) Cyclin-dependent kinase inhibitor 2A (melanoma, p16, inhibits CDK4) GO:0006309 GO:0006917 GO:0006919 GO:0008637 ENSG00000147889 ENSP00000355153 hsa+1029 CDKN2A CDKN2, MLM CDKN2A IDA IMP 9p21 Approved CDK4I, p16, INK4a, MTS1, CMM2, ARF, p19, p14, INK4, p16INK4a CDKN2A cyclin-dependent kinase inhibitor 2A (melanoma, p16, inhibits CDK4); Capable of inducing cell cycle arrest in G1 and G2 phases. Acts as a tumor suppressor. Binds to MDM2 and blocks its nucleocytoplasmic shuttling by sequestering it in the nucleolus. This inhibits the oncogenic action of MDM2 by blocking MDM2- induced degradation of p53 and enhancing p53-dependent transactivation and apoptosis. Also induces G2 arrest and apoptosis in a p53-independent manner by preventing the activation of cyclin B1/CDC2 complexes. Binds to BCL6 and down-regulates BCL6-induced transcriptional repression [...]
1030 CDKN2B 1030 HGNC:1788 Hs.72901 207530_s_at
236313_at
cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4) Cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4) ENSG00000147883 ENSP00000276925 hsa+1030 CDKN2B CDKN2B 9p21 Approved P15, MTS2, INK4B, TP15, CDK4I, p15INK4b CDKN2B cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4); Acts as a negative regulator of the proliferation of normal cells by interacting strongly with CDK4 and CDK6. This inhibits their ability to interact with cyclins D and to phosphorylate the retinoblastoma protein
1031 CDKN2C 1031 HGNC:1789 Hs.525324 Hs.706753 204159_at
211792_s_at
cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4) Cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4) GO:0006917 ENSG00000123080 ENSP00000262662 hsa+1031 CDKN2C CDKN2C IDA 1p32.3 Approved INK4C CDKN2C cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4); Interacts strongly with CDK6, weakly with CDK4. Inhibits cell growth and proliferation with a correlated dependence on endogenous retinoblastoma protein RB
1032 CDKN2D 1032 HGNC:1790 Hs.435051 210240_s_at
213586_at
cyclin-dependent kinase inhibitor 2D (p19, inhibits CDK4) Cyclin-dependent kinase inhibitor 2D (p19, inhibits CDK4) GO:0006916 GO:0043154 ENSG00000129355 ENSP00000337056 hsa+1032 CDKN2D CDKN2D IMP 19p13 Approved INK4D, p19 CDKN2D cyclin-dependent kinase inhibitor 2D (p19, inhibits CDK4); Interacts strongly with CDK4 and CDK6 and inhibits them
1869 E2F1 1869 HGNC:3113 Hs.654393 2028_s_at
204947_at
E2F transcription factor 1 E2F transcription factor 1 ENSG00000101412 ENSP00000345571 hsa+1869 E2F1 RBBP3 E2F1 20q11 Approved REACT_152 RBP3 E2F1 E2F transcription factor 1; Transcription activator that binds DNA cooperatively with dp proteins through the E2 recognition site, 5'-TTTC[CG]CGC- 3' found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication. The DRTF1/E2F complex functions in the control of cell-cycle progression from G1 to S phase. E2F-1 binds preferentially RB1 protein, in a cell-cycle dependent manner. It can mediate both cell proliferation and p53-dependent apoptosis
5925 RB1 5925 HGNC:9884 Hs.408528 203132_at
211540_s_at
retinoblastoma 1 Retinoblastoma 1 ENSG00000139687 ENSP00000267163 hsa+5925 RB1 OSRC RB1 13q14.2 Approved REACT_152 REACT_383 RB1 retinoblastoma 1; Key regulator of entry into cell division that acts as a tumor suppressor. Acts as a transcription repressor of E2F1 target genes. The underphosphorylated, active form of RB1 interacts with E2F1 and represses its transcription activity, leading to cell cycle arrest. Directly involved in heterochromatin formation by maintaining overall chromatin structure and, in particular, that of constitutive heterochromatin by stabilizing histone methylation. Recruits and targets histone methyltransferases SUV39H1, SUV420H1 and SUV420H2, leading to epigenetic transcriptional repres [...]
5933 RBL1 5933 HGNC:9893 Hs.207745 Hs.617220 1555003_at
1555004_a_at
1559307_s_at
205296_at
retinoblastoma-like 1 (p107) Retinoblastoma-like 1 (p107) ENSG00000080839 ENSP00000362768 hsa+5933 RBL1 RBL1 20q11.23 Approved p107, cp107, PRB1 RBL1 retinoblastoma-like 1 (p107); Key regulator of entry into cell division. Directly involved in heterochromatin formation by maintaining overall chromatin structure and, in particular, that of constitutive heterochromatin by stabilizing histone methylation. Recruits and targets histone methyltransferases SUV420H1 and SUV420H2, leading to epigenetic transcriptional repression. Controls histone H4 'Lys-20' trimethylation. Probably acts as a transcription repressor by recruiting chromatin-modifying enzymes to promoters. Potent inhibitor of E2F-mediated trans-activation. Forms a complex with [...]
7027 TFDP1 7027 HGNC:11749 Hs.79353 204147_s_at
212330_at
242538_at
242939_at
transcription factor Dp-1 Transcription factor Dp-1 ENSG00000198176 ENSP00000364519 hsa+7027 TFDP1 TFDP1 13q34 Approved Dp-1, DRTF1, DP1 TFDP1 transcription factor Dp-1; Can stimulate E2F-dependent transcription. Binds DNA cooperatively with E2F family members through the E2 recognition site, 5'-TTTC[CG]CGC-3', found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication. The DP2/E2F complex functions in the control of cell-cycle progression from G1 to S phase. The E2F-1/DP complex appears to mediate both cell proliferation and apoptosis
15 genes found.

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ID ApprovedSymbol EntrezGene HGNC
UniGeneID HugoName UniGeneName GeneOntologyID
ENSG ENSP KEGGID ApprovedSymbol2
PreviousSymbols NCIName Evidence Chromosome
Status Reactome_ID Aliases StringSymbol
StringName Affymetrics


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