NAME: mtor signaling

ID ApprovedSymbol EntrezGene HGNC UniGeneID Affymetrics HugoName UniGeneName GeneOntologyID ENSG ENSP KEGGID ApprovedSymbol2 PreviousSymbols NCIName Evidence Chromosome Status Reactome_ID Aliases StringSymbol StringName
207 AKT1 207 HGNC:391 Hs.525622 207163_s_at
v-akt murine thymoma viral oncogene homolog 1 V-akt murine thymoma viral oncogene homolog 1 GO:0006924 GO:0008633 ENSG00000142208 ENSP00000270202 hsa+207 AKT1 AKT1 EXP IMP 14q32.32-q32.33 Approved REACT_578 RAC, PKB, PRKBA, AKT AKT1 v-akt murine thymoma viral oncogene homolog 1; General protein kinase capable of phosphorylating several known proteins. Phosphorylates TBC1D4. Signals downstream of phosphatidylinositol 3-kinase (PI(3)K) to mediate the effects of various growth factors such as platelet-derived growth factor (PDGF), epidermal growth factor (EGF), insulin and insulin-like growth factor I (IGF-I). Plays a role in glucose transport by mediating insulin-induced translocation of the GLUT4 glucose transporter to the cell surface. Mediates the antiapoptotic effects of IGF-I. Mediates insulin-stimulated protei [...]
598 BCL2L1 598 HGNC:992 Hs.516966 206665_s_at
212312_at
215037_s_at
231228_at
BCL2-like 1 BCL2-like 1 GO:0001836 ENSG00000171552 ENSP00000302564 hsa+598 BCL2L1 BCL2L1 IDA 20q11.21 Approved REACT_578 BCLX, BCL2L, Bcl-X, bcl-xL, bcl-xS BCL2L1 BCL2-like 1; Potent inhibitor of cell death. Isoform Bcl-X(L) anti- apoptotic activity is inhibited by association with SIVA isoform 1. Inhibits activation of caspases (By similarity). Appears to regulate cell death by blocking the voltage-dependent anion channnel (VDAC) by binding to it and preventing the release of the caspase activator, cytochrome c, from the mitochondrial membrane. The Bcl-X(S) isoform promotes apoptosis
1051 CEBPB 1051 HGNC:1834 212501_at
CCAAT/enhancer binding protein (C/EBP), beta ENSG00000172216 TCF5 20q13.1 Approved
1052 CEBPD 1052 HGNC:1835 203973_s_at
213006_at
CCAAT/enhancer binding protein (C/EBP), delta 8p11.2-p11.1 Approved
1401 CRP 1401 HGNC:2367 205753_at
37020_at
C-reactive protein, pentraxin-related ENSG00000132693 1q23.2 Approved
2266 FGG 2266 HGNC:3694 219612_s_at
fibrinogen gamma chain ENSG00000171557 4q28 Approved
2353 FOS 2353 HGNC:3796 209189_at
FBJ murine osteosarcoma viral oncogene homolog 14q24.3 Approved
2308 FOXO1 2308 HGNC:3819 202723_s_at
202724_s_at
228484_s_at
forkhead box O1 ENSG00000150907 FOXO1 FKHR, FOXO1A 13q14.1 Approved
2549 GAB1 2549 HGNC:4066 1557030_at
1560382_at
207112_s_at
214987_at
225998_at
226002_at
229114_at
GRB2-associated binding protein 1 ENSG00000109458 4q31.1 Approved
9846 GAB2 9846 HGNC:14458 203853_s_at
GRB2-associated binding protein 2 ENSG00000033327 GAB2 11q13.4-q13.5 Approved
2885 GRB2 2885 HGNC:4566 growth factor receptor-bound protein 2 ENSG00000177885 17q24-q25 Approved
3055 HCK 3055 HGNC:4840 208018_s_at
hemopoietic cell kinase ENSG00000101336 20q11-q12 Approved
7184 HSP90B1 7184 HGNC:12028 200598_s_at
200599_s_at
216449_x_at
216450_x_at
heat shock protein 90kDa beta (Grp94), member 1 TRA1 12q24.2-q24.3 Approved
3569 IL6 3569 HGNC:6018 205207_at
interleukin 6 ENSG00000136244 IFNB2 7p21-p15 Approved
3570 IL6R 3570 HGNC:6019 205945_at
217489_s_at
226333_at
interleukin 6 receptor ENSG00000160712 1q21 Approved
3572 IL6ST 3572 HGNC:6021 204863_s_at
204864_s_at
211000_s_at
212195_at
212196_at
234474_x_at
234967_at
interleukin 6 signal transducer ENSG00000134352 5q11.2 Approved
3659 IRF1 3659 HGNC:6116 202531_at
238725_at
interferon regulatory factor 1 ENSG00000125347 5q23-q31 Approved
3716 JAK1 3716 HGNC:6190 1552610_a_at
1552611_a_at
1562103_at
201648_at
239695_at
240613_at
Janus kinase 1 ENSG00000162434 JAK1B 1p32.3-p31.3 Approved
3717 JAK2 3717 HGNC:6192 1562031_at
205841_at
205842_s_at
Janus kinase 2 ENSG00000096968 9p24 Approved
3725 JUN 3725 HGNC:6204 201464_x_at
201465_s_at
201466_s_at
213281_at
jun proto-oncogene ENSG00000177606 1p32-p31 Approved
3726 JUNB 3726 HGNC:6205 201473_at
jun B proto-oncogene 19p13.13 Approved
3929 LBP 3929 HGNC:6517 211652_s_at
214461_at
lipopolysaccharide binding protein ENSG00000129988 20q11.23 Approved
8543 LMO4 8543 HGNC:6644 209204_at
209205_s_at
227155_at
229537_at
241922_at
LIM domain only 4 ENSG00000143013 1p22.3 Approved
6416 MAP2K4 6416 HGNC:6844 Hs.514681 203265_s_at
203266_s_at
mitogen-activated protein kinase kinase 4 Mitogen-activated protein kinase kinase 4 ENSG00000065559 ENSP00000262445 MAP2K4 SERK1 MAP2K4 17p11.2 Approved MEK4, JNKK1, PRKMK4, MKK4 MKK4 mitogen-activated protein kinase kinase 4; Dual specificity kinase that activates the JUN kinases MAPK8 (JNK1) and MAPK9 (JNK2) as well as MAPK14 (p38) but not MAPK1 (ERK2) or MAPK3 (ERK1)
5608 MAP2K6 5608 HGNC:6846 205698_s_at
205699_at
mitogen-activated protein kinase kinase 6 MAP2K6 PRKMK6 17q Approved
5600 MAPK11 5600 HGNC:6873 206040_s_at
211499_s_at
211500_at
mitogen-activated protein kinase 11 ENSG00000185386 MAPK11 PRKM11 22q13.33 Approved
1432 MAPK14 1432 HGNC:6876 Hs.588289 202530_at
210449_x_at
211087_x_at
211561_x_at
mitogen-activated protein kinase 14 Mitogen-activated protein kinase 14 ENSG00000112062 ENSP00000229794 MAPK14 CSPB1, CSBP1, CSBP2 MAPK14 6p21.3-p21.2 Approved PRKM14, p38, Mxi2, PRKM15 Mxi2 mitogen-activated protein kinase 14; Responds to activation by environmental stress, pro- inflammatory cytokines and lipopolysaccharide (LPS) by phosphorylating a number of transcription factors, such as ELK1 and ATF2 and several downstream kinases, such as MAPKAPK2 and MAPKAPK5. Plays a critical role in the production of some cytokines, for example IL-6. May play a role in stabilization of EPO mRNA during hypoxic stress. Isoform Mxi2 activation is stimulated by mitogens and oxidative stress and only poorly phosphorylates ELK1 and ATF2. Isoform Exip may play a role in the early onset o [...]
4170 MCL1 4170 HGNC:6943 200796_s_at
200797_s_at
200798_x_at
214056_at
214057_at
227175_at
myeloid cell leukemia sequence 1 (BCL2-related) ENSG00000143384 MCL1 1q21 Approved
4286 MITF 4286 HGNC:7105 1554874_at
207233_s_at
226066_at
microphthalmia-associated transcription factor ENSG00000187098 WS2A, WS2 3p14.1-p12.3 Approved
4609 MYC 4609 HGNC:7553 Hs.202453 202431_s_at
244089_at
v-myc myelocytomatosis viral oncogene homolog (avian) Similar to ORF 114 ENSG00000136997 ENSP00000367207 MYC MYC 8q24 Approved c-Myc, bHLHe39 MYC v-myc myelocytomatosis viral oncogene homolog (avian); Participates in the regulation of gene transcription. Binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Seems to activate the transcription of growth-related genes
8554 PIAS1 8554 HGNC:2752 217862_at
217863_at
217864_s_at
protein inhibitor of activated STAT, 1 DDXBP1 15q Approved
10401 PIAS3 10401 HGNC:16861 203035_s_at
protein inhibitor of activated STAT, 3 ENSG00000131788 1q21 Approved
5290 PIK3CA 5290 HGNC:8975 Hs.553498 Hs.85701 204369_at
231854_at
235980_at
phosphoinositide-3-kinase, catalytic, alpha polypeptide Phosphoinositide-3-kinase, catalytic, alpha polypeptide ENSG00000121879 ENSP00000263967 hsa+5290 PIK3CA PIK3CA 3q26.3 Approved REACT_498 PIK3CA phosphoinositide-3-kinase, catalytic, alpha polypeptide; Phosphorylates PtdIns, PtdIns4P and PtdIns(4,5)P2 with a preference for PtdIns(4,5)P2
5295 PIK3R1 5295 HGNC:8979 Hs.132225 212239_at
212240_s_at
212249_at
phosphoinositide-3-kinase, regulatory subunit 1 (alpha) Phosphoinositide-3-kinase, regulatory subunit 1 (alpha) ENSG00000145675 ENSP00000274335 hsa+5295 PIK3R1 PIK3R1 5q13.1 Approved REACT_498 GRB1, p85-ALPHA, p85 PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha); Binds to activated (phosphorylated) protein-Tyr kinases, through its SH2 domain, and acts as an adapter, mediating the association of the p110 catalytic unit to the plasma membrane. Necessary for the insulin-stimulated increase in glucose uptake and glycogen synthesis in insulin-sensitive tissues
5580 PRKCD 5580 HGNC:9399 Hs.155342 202545_at
protein kinase C, delta Protein kinase C, delta ENSG00000163932 ENSP00000331602 PRKCD PRKCD 3p21.31 Approved PRKCD protein kinase C, delta; This is calcium-independent, phospholipid-dependent, serine- and threonine-specific enzyme. PKC is activated by diacylglycerol which in turn phosphorylates a range of cellular proteins. PKC also serves as the receptor for phorbol esters, a class of tumor promoters. May play a role in antigen-dependent control of B-cell function. Phosphorylates MUC1 in the C-terminal and regulates the interaction between MUC1 and beta-catenin
5781 PTPN11 5781 HGNC:9644 1552637_at
205867_at
205868_s_at
209895_at
209896_s_at
212610_at
protein tyrosine phosphatase, non-receptor type 11 ENSG00000179295 NS1 12q24.1 Approved
5791 PTPRE 5791 HGNC:9669 1559018_at
221840_at
233978_at
protein tyrosine phosphatase, receptor type, E ENSG00000132334 10q26 Approved
5879 RAC1 5879 HGNC:9801 1567457_at
1567458_s_at
208640_at
208641_s_at
ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1) ENSG00000136238 7p22 Approved
9021 SOCS3 9021 HGNC:19391 suppressor of cytokine signaling 3 17q25.3 Approved
6654 SOS1 6654 HGNC:11187 1557354_at
212777_at
212780_at
227426_at
230337_at
son of sevenless homolog 1 (Drosophila) ENSG00000115904 GINGF 2p21 Approved
6772 STAT1 6772 HGNC:11362 Hs.642990 200887_s_at
209969_s_at
AFFX-HUMISGF3A-M97935_3_at
AFFX-HUMISGF3A-M97935_5_at
AFFX-HUMISGF3A-M97935_MA_at
AFFX-HUMISGF3A-M97935_MB_at
signal transducer and activator of transcription 1, 91kDa Signal transducer and activator of transcription 1, 91kDa ENSG00000115415 ENSP00000354394 STAT1 STAT1 2q32.2-q32.3 Approved STAT91, ISGF-3 STAT1 signal transducer and activator of transcription 1, 91kDa; Signal transducer and activator of transcription that mediates signaling by interferons (IFNs). Following type I IFN (IFN-alpha and IFN-beta) binding to cell surface receptors, Jak kinases (TYK2 and JAK1) are activated, leading to tyrosine phosphorylation of STAT1 and STAT2. The phosphorylated STATs dimerize, associate with ISGF3G/IRF-9 to form a complex termed ISGF3 transcription factor, that enters the nucleus. ISGF3 binds to the IFN stimulated response element (ISRE) to activate the transcription of interferon stimulated gen [...]
6774 STAT3 6774 HGNC:11364 208991_at
208992_s_at
225289_at
243213_at
signal transducer and activator of transcription 3 (acute-phase response factor) ENSG00000168610 17q21 Approved
7076 TIMP1 7076 HGNC:11820 201666_at
TIMP metallopeptidase inhibitor 1 ENSG00000102265 TIMP, CLGI Xp11.3-p11.23 Approved
8600 TNFSF11 8600 HGNC:11926 tumor necrosis factor (ligand) superfamily, member 11 ENSG00000120659 13q14 Approved
7297 TYK2 7297 HGNC:12440 205546_s_at
tyrosine kinase 2 ENSG00000105397 19p13.2 Approved
7409 VAV1 7409 HGNC:12657 206219_s_at
vav 1 guanine nucleotide exchange factor VAV 19p13.2 Approved
46 genes found.

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ID ApprovedSymbol EntrezGene HGNC
UniGeneID HugoName UniGeneName GeneOntologyID
ENSG ENSP KEGGID ApprovedSymbol2
PreviousSymbols NCIName Evidence Chromosome
Status Reactome_ID Aliases StringSymbol
StringName Affymetrics


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