NAME: Canonical NF-kappaB

ID ApprovedSymbol EntrezGene HGNC UniGeneID Affymetrics HugoName UniGeneName GeneOntologyID ENSG ENSP KEGGID ApprovedSymbol2 PreviousSymbols NCIName Evidence Chromosome Status Reactome_ID Aliases StringSymbol StringName
472 ATM 472 HGNC:795 Hs.367437 1553387_at
1554631_at
1570352_at
208442_s_at
210858_x_at
212672_at
ataxia telangiectasia mutated Ataxia telangiectasia mutated ENSG00000149311 ENSP00000278616 hsa+472 ATM ATA, ATDC, ATC, ATD ATM 11q22-q23 Approved TEL1, TELO1 ATM ataxia telangiectasia mutated; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]-Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also involved in signal transduction and cell cycle control. May function as a tumor suppressor. Necessary for activation of ABL1 and SAPK. Phosphorylate [...]
8915 BCL10 8915 HGNC:989 1557257_at
1557258_a_at
205263_at
B-cell CLL/lymphoma 10 ENSG00000142867 1p22 Approved
329 BIRC2 329 HGNC:590 Hs.696238 202076_at
baculoviral IAP repeat-containing 2 Baculoviral IAP repeat-containing 2 ENSG00000110330 ENSP00000227758 hsa+329 BIRC2 API1 BIRC2 11q22 Approved cIAP1, hiap-2, MIHB, RNF48 MIHB baculoviral IAP repeat-containing 2; Apoptotic suppressor. The BIR motifs region interacts with TNF receptor associated factors 1 and 2 (TRAF1 and TRAF2) to form an heteromeric complex, which is then recruited to the tumor necrosis factor receptor 2 (TNFR2)
1147 CHUK 1147 HGNC:1974 Hs.198998 209666_s_at
conserved helix-loop-helix ubiquitous kinase Conserved helix-loop-helix ubiquitous kinase ENSG00000213341 ENSP00000359424 hsa+1147 CHUK TCF16 CHUK 10q24-q25 Approved REACT_6900 IKK1, IKK-alpha, IkBKA, NFKBIKA, IKKA - conserved helix-loop-helix ubiquitous kinase; Acts as part of the IKK complex in the conventional pathway of NF-kappa-B activation and phosphorylates inhibitors of NF-kappa-B thus leading to the dissociation of the inhibitor/NF- kappa-B complex and ultimately the degradation of the inhibitor. As part of the non-canonical pathway of NF-kappa-B activation, the MAP3K14-activated CHUK/IKKA homodimer phosphorylates NFKB2/p100 associated with RelB, inducing its proteolytic processing to NFKB2/p52 and the formation of NF-kappa-B RelB-p52 complexes. Also phosphorylates NCOA3. Phosphorylates 'S [...]
1540 CYLD 1540 HGNC:2584 213295_at
214272_at
221903_s_at
221905_at
222142_at
39582_at
60084_at
cylindromatosis (turban tumor syndrome) ENSP00000308928 CYLD CYLD1 16q12-q13 Approved KIAA0849, USPL2 cylindromatosis (turban tumor syndrome); Negative regulator of TRAF2 and NF-kappa-B signaling pathway. Has deubiquitinating activity that is directed towards non-'Lys-48'-linked polyubiquitin chains. The inhibition of NF- kappa-B activation is mediated at least in part, by the deubiquitination and inactivation of TRAF2 and, to a lesser extent, TRAF6
23085 ERC1 23085 HGNC:17072 1552663_a_at
1555294_a_at
1563947_a_at
215606_s_at
216440_at
226049_at
235820_at
ELKS/RAB6-interacting/CAST family member 1 ENSG00000082805 ERC1 RAB6IP2 12p13.3 Approved
3551 IKBKB 3551 HGNC:5960 Hs.656458 209341_s_at
209342_s_at
211027_s_at
inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta Inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta ENSG00000104365 ENSP00000339151 hsa+3551 IKBKB IKBKB 8p11.2 Approved REACT_6900 IKK2, NFKBIKB, IKK-beta, IKKB IKKB inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta; Acts as part of the IKK complex in the conventional pathway of NF-kappa-B activation and phosphorylates inhibitors of NF-kappa-B thus leading to the dissociation of the inhibitor/NF- kappa-B complex and ultimately the degradation of the inhibitor. Also phosphorylates NCOA3
8517 IKBKG 8517 HGNC:5961 Hs.43505 209929_s_at
36004_at
inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma Inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma ENSG00000073009 ENSP00000358622 hsa+8517 IKBKG IP2, IP1 IKBKG Xq28 Approved REACT_6900 IKK-gamma, NEMO, Fip3p, FIP-3, FIP3 IKBKG inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma; Regulatory subunit of the IKK core complex which phosphorylates inhibitors of NF-kappa-B thus leading to the dissociation of the inhibitor/NF-kappa-B complex and ultimately the degradation of the inhibitor. Also considered to be a mediator for TAX activation of NF-kappa-B. Could be implicated in NF-kappa- B-mediated protection from cytokine toxicity (By similarity)
10892 MALT1 10892 HGNC:6819 208309_s_at
210017_at
210018_x_at
mucosa associated lymphoid tissue lymphoma translocation gene 1 ENSG00000172175 MLT 18q21 Approved
4790 NFKB1 4790 HGNC:7794 Hs.654408 209239_at
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 Nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 ENSG00000109320 ENSP00000226574 hsa+4790 NFKB1 NFKB1 4q24 Approved REACT_6900 KBF1, p105, NFKB-p50, p50, NF-kappabeta KBF1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1; NF-kappa-B is a pleiotropic transcription factor which is present in almost all cell types and is involved in many biological processed such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. NF- kappa-B is a homo- or heterodimeric complex formed by the Rel-like domain-containing proteins RELA/p65, RELB, NFKB1/p105, NFKB1/p50, REL and NFKB2/p52 and the heterodimeric p65-p50 complex appears to be most abundant one. The dimers bind at kappa-B sites in the DNA of their target genes and [...]
4792 NFKBIA 4792 HGNC:7797 Hs.81328 201502_s_at
nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha Nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha ENSG00000100906 ENSP00000216797 hsa+4792 NFKBIA NFKBI NFKBIA 14q13 Approved REACT_6900 IKBA, MAD-3, IkappaBalpha IKBA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha; Inhibits the activity of dimeric NF-kappa-B/REL complexes by trapping REL dimers in the cytoplasm through masking of their nuclear localization signals. On cellular stimulation by immune and proinflammatory responses, becomes phosphorylated promoting ubiquitination and degradation, enabling the dimeric RELA to tranlocate to the nucleus and activate transcription
64127 NOD2 64127 HGNC:5331 220066_at
nucleotide-binding oligomerization domain containing 2 ENSG00000167207 IBD1, CARD15 16q12 Approved
5578 PRKCA 5578 HGNC:9393 1560074_at
206923_at
213093_at
215194_at
215195_at
protein kinase C, alpha PKCA 17q22-q24 Approved
5901 RAN 5901 HGNC:9846 200750_s_at
RAN, member RAS oncogene family ENSG00000132341 12q24.33 Approved
5970 RELA 5970 HGNC:9955 Hs.502875 201783_s_at
209878_s_at
230202_at
v-rel reticuloendotheliosis viral oncogene homolog A (avian) V-rel reticuloendotheliosis viral oncogene homolog A (avian) GO:0006916 ENSG00000173039 ENSP00000384273 hsa+5970 RELA NFKB3 RELA IDA 11q13 Approved REACT_6900 p65 RELA v-rel reticuloendotheliosis viral oncogene homolog A (avian); NF-kappa-B is a pleiotropic transcription factor which is present in almost all cell types and is involved in many biological processed such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. NF- kappa-B is a homo- or heterodimeric complex formed by the Rel-like domain-containing proteins RELA/p65, RELB, NFKB1/p105, NFKB1/p50, REL and NFKB2/p52 and the heterodimeric p65-p50 complex appears to be most abundant one. The dimers bind at kappa-B sites in the DNA of their target genes and the ind [...]
8767 RIPK2 8767 HGNC:10020 209544_at
209545_s_at
receptor-interacting serine-threonine kinase 2 ENSG00000104312 8q21 Approved
23145 SSPO 23145 HGNC:21998 234349_at
SCO-spondin ENSG00000197558 7q36.1 Approved
7124 TNF 7124 HGNC:11892 Hs.241570 207113_s_at
tumor necrosis factor (TNF superfamily, member 2) Tumor necrosis factor (TNF superfamily, member 2) GO:0006916 GO:0006919 GO:0006927 ENSG00000206439 ENSP00000392858 hsa+7124 TNF TNFA TNF IDA 6p21.3 Approved REACT_578 TNFSF2, DIF, TNF-alpha ENSG00000206439 tumor necrosis factor (TNF superfamily, member 2); Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation
7128 TNFAIP3 7128 HGNC:11896 202643_s_at
202644_s_at
tumor necrosis factor, alpha-induced protein 3 ENSG00000118503 ENSP00000237289 TNFAIP3 6q23-q25 Approved A20, OTUD7C tumor necrosis factor, alpha-induced protein 3; Essential component of a ubiquitin-editing protein complex, comprising also RNF11, ITCH and TAX1BP1, that ensures the transient nature of inflammatory signaling pathways. Upon TNF stimulation, deubiquitinates 'Lys-63'-polyubiquitin chains on RIPK1 and catalyzes the formation of 'Lys-48'-polyubiquitin chains. This leads to RIPK1 proteosomal degradation and consequently termination of the TNF- or LPS-mediated activation of NF-kappa-B. In vitro able to deubiquitinate both 'Lys-48'- and 'Lys-63' polyubiquitin chains. Inhibitor of programmed c [...]
7132 TNFRSF1A 7132 HGNC:11916 Hs.279594 207643_s_at
tumor necrosis factor receptor superfamily, member 1A Tumor necrosis factor receptor superfamily, member 1A ENSG00000067182 ENSP00000162749 hsa+7132 TNFRSF1A TNFR1 TNFRSF1A 12p13.2 Approved REACT_578 TNF-R, TNFAR, TNFR60, TNF-R-I, CD120a, TNF-R55 TNFR1 tumor necrosis factor receptor superfamily, member 1A; Receptor for TNFSF2/TNF-alpha and homotrimeric TNFSF1/lymphotoxin-alpha. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate- specific cysteine proteases) mediating apoptosis. Contributes to the induction of non-cytocidal TNF effects including anti-viral state and activation of the acid sphingomyelinase
7189 TRAF6 7189 HGNC:12036 205558_at
TNF receptor-associated factor 6 TRAF6 11p12 Approved
7323 UBE2D3 7323 HGNC:12476 200667_at
200668_s_at
200669_s_at
223966_at
229355_at
240383_at
ubiquitin-conjugating enzyme E2D 3 ENSG00000109332 4q24 Approved
7514 XPO1 7514 HGNC:12825 Hs.370770 208775_at
235927_at
244012_x_at
exportin 1 (CRM1 homolog, yeast) Exportin 1 (CRM1 homolog, yeast) ENSG00000082898 ENSP00000195419 XPO1 XPO1 2p15 Approved CRM1 exportin 1 (CRM1 homolog, yeast); Mediates the nuclear export of cellular proteins (cargos) bearing a leucine-rich nuclear export signal (NES) and of RNAs. In the nucleus, in association with RANBP3, binds cooperatively to the NES on its target protein and to the GTPase RAN in its active GTP-bound form (Ran-GTP). Docking of this complex to the nuclear pore complex (NPC) is mediated through binding to nucleoporins. Upon transit of an nuclear export complex into the cytoplasm, disassembling of the complex and hydrolysis of Ran-GTP to Ran-GDP (induced by RANBP1 and RANGAP1, respectively) [...]
23 genes found.

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ID ApprovedSymbol EntrezGene HGNC
UniGeneID HugoName UniGeneName GeneOntologyID
ENSG ENSP KEGGID ApprovedSymbol2
PreviousSymbols NCIName Evidence Chromosome
Status Reactome_ID Aliases StringSymbol
StringName Affymetrics


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