NAME: ATR signaling

ID ApprovedSymbol EntrezGene HGNC UniGeneID Affymetrics HugoName UniGeneName GeneOntologyID ENSG ENSP KEGGID ApprovedSymbol2 PreviousSymbols NCIName Evidence Chromosome Status Reactome_ID Aliases StringSymbol StringName
545 ATR 545 HGNC:882 Hs.271791 209902_at
209903_s_at
233288_at
ataxia telangiectasia and Rad3 related Ataxia telangiectasia and Rad3 related ENSG00000175054 ENSP00000343741 hsa+545 ATR ATR 3q22-q24 Approved FRP1, SCKL, SCKL1, MEC1 ENSG00000175054 ataxia telangiectasia and Rad3 related; Serine/threonine protein kinase which activates checkpoint signaling upon genotoxic stresses such as ionizing radiation (IR), ultraviolet light (UV), or DNA replication stalling, thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]-Q. Phosphorylates BRCA1, CHEK1, MCM2, RAD17, RPA2, SMC1 and TP53/p53, which collectively inhibit DNA replication and mitosis and promote DNA repair, recombination and apoptosis. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at sites of DNA damage, thereby regulating DNA damag [...]
84126 ATRIP 84126 HGNC:33499 1552937_s_at
ATR interacting protein ENSG00000164053 ENSP00000323099 ATRIP 3p24.3-p22.1 Approved FLJ12343, MGC20625, MGC21482, MGC26740 ATR interacting protein; Required for checkpoint signaling after DNA damage. Required for ATR expression, possibly by stabilizing the protein
675 BRCA2 675 HGNC:1101 Hs.34012 208368_s_at
214727_at
breast cancer 2, early onset Breast cancer 2, early onset GO:0006289 ENSG00000139618 ENSP00000369497 hsa+675 BRCA2 FANCD1, FACD, FANCD BRCA2 IMP 13q12-q13 Approved FAD, FAD1, BRCC2 BRCA2 breast cancer 2, early onset; Involved in double-strand break repair and/or homologous recombination. May participate in S phase checkpoint activation
890 CCNA2 890 HGNC:1578 Hs.58974 203418_at
213226_at
cyclin A2 Cyclin A2 ENSG00000145386 ENSP00000274026 hsa+890 CCNA2 CCNA, CCN1 CCNA2 4q25-q31 Approved REACT_152 REACT_383 REACT_6850 CCNA2 cyclin A2; Essential for the control of the cell cycle at the G1/S (start) and the G2/M (mitosis) transitions
993 CDC25A 993 HGNC:1725 Hs.437705 1555772_a_at
204695_at
204696_s_at
cell division cycle 25 homolog A (S. pombe) Cell division cycle 25 homolog A (S. pombe) ENSG00000164045 ENSP00000303706 hsa+993 CDC25A CDC25A 3p21 Approved CDC25A cell division cycle 25 homolog A (S. pombe); Tyrosine protein phosphatase which functions as a dosage-dependent inducer of mitotic progression. Directly dephosphorylates CDC2 and stimulates its kinase activity. Also dephosphorylates CDK2 in complex with cyclin E, in vitro
995 CDC25C 995 HGNC:1727 Hs.656 205167_s_at
216914_at
217010_s_at
cell division cycle 25 homolog C (S. pombe) Cell division cycle 25 homolog C (S. pombe) ENSG00000158402 ENSP00000321656 hsa+995 CDC25C CDC25 CDC25C 5q31 Approved CDC25C cell division cycle 25 homolog C (S. pombe); Functions as a dosage-dependent inducer in mitotic control. It is a tyrosine protein phosphatase required for progression of the cell cycle. It directly dephosphorylates CDC2 and activate its kinase activity
990 CDC6 990 HGNC:1744 Hs.405958 203967_at
203968_s_at
cell division cycle 6 homolog (S. cerevisiae) Cell division cycle 6 homolog (S. cerevisiae) ENSG00000094804 ENSP00000209728 hsa+990 CDC6 CDC18L CDC6 17q21.3 Approved CDC6 cell division cycle 6 homolog (S. cerevisiae); Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated
1017 CDK2 1017 HGNC:1771 Hs.19192 204252_at
211803_at
211804_s_at
cyclin-dependent kinase 2 Cyclin-dependent kinase 2 ENSG00000123374 ENSP00000266970 hsa+1017 CDK2 CDK2 12q13 Approved CDK2 cyclin-dependent kinase 2; Involved in the control of the cell cycle. Interacts with cyclins A, B1, B3, D, or E. Activity of CDK2 is maximal during S phase and G2
22897 CEP164 22897 HGNC:29182 1558953_s_at
204250_s_at
204251_s_at
centrosomal protein 164kDa ENSG00000110274 ENSP00000278935 CEP164 11q23.3 Approved KIAA1052 centrosomal protein 164kDa; Plays a role in microtubule organization and/or maintenance for the formation of primary cilia (PC), a microtubule-based structure that protrudes from the surface of epithelial cells. Plays a critical role in G2/M checkpoint and nuclear divisions. A key player in the DNA damage-activated ATR/ATM signaling cascade since it is required for the proper phosphorylation of H2AX, RPA,CHK2 and CHK1. Plays a critical role in chromosome segregation, acting as a mediator required for the maintenance of genomic stability through modulation of MDC1, RPA and CHK1
1111 CHEK1 1111 HGNC:1925 Hs.24529 205393_s_at
205394_at
CHK1 checkpoint homolog (S. pombe) CHK1 checkpoint homolog (S. pombe) ENSG00000149554 ENSP00000278916 hsa+1111 CHEK1 CHEK1 11q24.2 Approved CHK1 CHEK1 CHK1 checkpoint homolog (S. pombe); Required for checkpoint mediated cell cycle arrest in response to DNA damage or the presence of unreplicated DNA. May also negatively regulate cell cycle progression during unperturbed cell cycles. Recognizes the substrate consensus sequence [R-X-X- S/T]. Binds to and phosphorylates CDC25A, CDC25B and CDC25C. Phosphorylation of CDC25A at 'Ser-178' and 'Thr-507' and phosphorylation of CDC25C at 'Ser-216' creates binding sites for 14-3-3 proteins which inhibit CDC25A and CDC25C. Phosphorylation of CDC25A at 'Ser-76', 'Ser-124', 'Ser-178', 'Ser-279' and [...]
63967 CLSPN 63967 HGNC:19715 1553120_at
219621_at
242150_at
243840_at
claspin ENSG00000092853 ENSP00000312995 CLSPN 1p34.3 Approved claspin homolog (Xenopus laevis); Required for checkpoint mediated cell cycle arrest in response to inhibition of DNA replication or to DNA damage induced by both ionizing and UV irradiation. Adapter protein which binds to BRCA1 and the checkpoint kinase CHEK1 and facilitates the ATR- dependent phosphorylation of both proteins. Can also bind specifically to branched DNA structures and may associate with S- phase chromatin following formation of the pre-replication complex (pre-RC). This may indicate a role for this protein as a sensor which monitors the integrity of DNA replication forks
2177 FANCD2 2177 HGNC:3585 Hs.208388 1568889_at
1568891_x_at
223545_at
242560_at
Fanconi anemia, complementation group D2 Fanconi anemia, complementation group D2 ENSG00000144554 ENSP00000287647 FANCD2 FACD, FANCD FANCD2 3p25.3 Approved FAD, FA-D2 FACD Fanconi anemia, complementation group D2; Required for maintenance of chromosomal stability. Promotes accurate and efficient pairing of homologs during meiosis. Involved in the repair of DNA double-strand breaks, both by homologous recombination and single-strand annealing. May participate in S phase and G2 phase checkpoint activation upon DNA damage. Promotes BRCA2/FANCD1 loading onto damaged chromatin. May also be involved in B-cell immunoglobulin isotype switching
23291 FBXW11 23291 HGNC:13607 209455_at
209456_s_at
F-box and WD repeat domain containing 11 ENSG00000072803 FBXW1B 5q35.1 Approved
3364 HUS1 3364 HGNC:5309 204883_s_at
204884_s_at
217618_x_at
HUS1 checkpoint homolog (S. pombe) ENSG00000136273 ENSP00000258774 HUS1 7p13-p12 Approved HUS1 checkpoint homolog (S. pombe); Component of the 9-1-1 cell-cycle checkpoint response complex that plays a major role in DNA repair. The 9-1-1 complex is recruited to DNA lesion upon damage by the RAD17-replication factor C (RFC) clamp loader complex. Acts then as a sliding clamp platform on DNA for several proteins involved in long-patch base excision repair (LP-BER). The 9-1-1 complex stimulates DNA polymerase beta (POLB) activity by increasing its affinity for the 3'-OH end of the primer-template and stabilizes POLB to those sites where LP-BER proceeds; endonuclease FEN1 cleavag [...]
4171 MCM2 4171 HGNC:6944 Hs.477481 202107_s_at
minichromosome maintenance complex component 2 Minichromosome maintenance complex component 2 ENSG00000073111 ENSP00000265056 hsa+4171 MCM2 CCNL1, CDCL1 MCM2 3q21 Approved D3S3194, KIAA0030, BM28, cdc19 BM28 minichromosome maintenance complex component 2; Acts as a factor that allows the DNA to undergo a single round of replication per cell cycle. Required for the entry in S phase and for cell division
4176 MCM7 4176 HGNC:6950 Hs.438720 208795_s_at
210983_s_at
minichromosome maintenance complex component 7 Minichromosome maintenance complex component 7 ENSG00000166508 ENSP00000307288 hsa+4176 MCM7 MCM2 MCM7 7q21.3-q22.1 Approved CDC47 MCM7 minichromosome maintenance complex component 7; Acts as a factor that allows the DNA to undergo a single round of replication per cell cycle. Required for DNA replication and cell proliferation. Required for S-phase checkpoint activation upon UV-induced damage
4193 MDM2 4193 HGNC:6973 Hs.567303 205385_at
205386_s_at
211832_s_at
217373_x_at
217542_at
225160_x_at
229711_s_at
237891_at
244616_x_at
Mdm2 p53 binding protein homolog (mouse) Mdm2 p53 binding protein homolog (mouse) ENSG00000135679 ENSP00000417281 hsa+4193 MDM2 MDM2 12q13-q14 Approved HDM2, HDMX HDM2 Mdm2 p53 binding protein homolog (mouse); Inhibits TP53/p53- and TP73/p73-mediated cell cycle arrest and apoptosis by binding its transcriptional activation domain. Functions as a ubiquitin ligase E3, in the presence of E1 and E2, toward p53 and itself. Permits the nuclear export of p53 and targets it for proteasome-mediated proteolysis. Functions as an ubiquitin ligase E3 toward ARRB1 (By similarity)
4683 NBN 4683 HGNC:7652 Hs.492208 202905_x_at
202906_s_at
202907_s_at
217299_s_at
240510_at
nibrin Nibrin ENSG00000104320 ENSP00000265433 hsa+4683 NBN NBS, NBS1 NBN 8q21-q24 Approved ATV, AT-V2, AT-V1 NBN nibrin; Component of the MRE11/RAD50/NBN (MRN complex) which plays a critical role in the cellular response to DNA damage and the maintenance of chromosome integrity. The complex is involved in double-strand break (DSB) repair, DNA recombination, maintenance of telomere integrity, cell cycle checkpoint control and meiosis. The complex possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity, which are provided by MRE11A. RAD50 may be required to bind DNA ends and hold them in close proximity. NBN modulate the DNA damage signal sensing by recru [...]
5347 PLK1 5347 HGNC:9077 Hs.592049 202240_at
polo-like kinase 1 (Drosophila) Polo-like kinase 1 (Drosophila) ENSG00000166851 ENSP00000300093 hsa+5347 PLK1 PLK PLK1 16p Approved PLK1 polo-like kinase 1 (Drosophila); Serine/threonine-protein kinase that performs several important functions throughout M phase of the cell cycle, including the regulation of centrosome maturation and spindle assembly, the removal of cohesins from chromosome arms, the inactivation of APC/C inhibitors, and the regulation of mitotic exit and cytokinesis
5515 PPP2CA 5515 HGNC:9299 Hs.483408 208652_at
235502_at
238719_at
protein phosphatase 2 (formerly 2A), catalytic subunit, alpha isoform Protein phosphatase 2 (formerly 2A), catalytic subunit, alpha isoform ENSG00000113575 ENSP00000418447 PPP2CA PPP2CA 5q31.1 Approved PPP2CA protein phosphatase 2 (formerly 2A), catalytic subunit, alpha isoform; PP2A can modulate the activity of phosphorylase B kinase casein kinase 2, mitogen-stimulated S6 kinase, and MAP-2 kinase. Can dephosphorylate SV40 large T antigen and p53. Dephosphorylates SV40 large T antigen, preferentially on serine residues 120, 123, 677, and perhaps 679. The C subunit was most active, followed by the AC form, which was more active than the ABC form, and activity of all three forms was strongly stimulated by manganese, and to a lesser extent by magnesium. Dephosphorylation by the AC form, but no [...]
5518 PPP2R1A 5518 HGNC:9302 200695_at
protein phosphatase 2, regulatory subunit A, alpha ENSG00000105568 ENSP00000324804 PPP2R1A 19q13 Approved PR65A, PP2A-Aalpha protein phosphatase 2 (formerly 2A), regulatory subunit A, alpha isoform; The PR65 subunit of protein phosphatase 2A serves as a scaffolding molecule to coordinate the assembly of the catalytic subunit and a variable regulatory B subunit
5521 PPP2R2B 5521 HGNC:9305 205643_s_at
213849_s_at
protein phosphatase 2, regulatory subunit B, beta ENSG00000156475 SCA12 5q32 Approved
5810 RAD1 5810 HGNC:9806 Hs.531879 204460_s_at
204461_x_at
210216_x_at
228535_at
235253_at
RAD1 homolog (S. pombe) RAD1 homolog (S. pombe) ENSG00000113456 ENSP00000340879 RAD1 RAD1 5p13 Approved HRAD1, REC1 ENSG00000113456 RAD1 homolog (S. pombe); Component of the 9-1-1 cell-cycle checkpoint response complex that plays a major role in DNA repair. The 9-1-1 complex is recruited to DNA lesion upon damage by the RAD17-replication factor C (RFC) clamp loader complex. Acts then as a sliding clamp platform on DNA for several proteins involved in long-patch base excision repair (LP-BER). The 9-1-1 complex stimulates DNA polymerase beta (POLB) activity by increasing its affinity for the 3'-OH end of the primer-template and stabilizes POLB to those sites where LP-BER proceeds; endonuclease FEN1 cleavage activity [...]
5884 RAD17 5884 HGNC:9807 Hs.16184 207405_s_at
210826_x_at
211228_s_at
RAD17 homolog (S. pombe) RAD17 homolog (S. pombe) ENSG00000152942 ENSP00000370151 RAD17 RAD17 5q13 Approved Rad24, RAD17Sp, CCYC RAD17 RAD17 homolog (S. pombe); Essential for sustained cell growth, maintenance of chromosomal stability, and ATR-dependent checkpoint activation upon DNA damage. Has a weak ATPase activity required for binding to chromatin. Participates in the recruitment of the RAD1-RAD9- HUS1 complex onto chromatin, and in CHEK1 activation. May also serve as a sensor of DNA replication progression, and may be involved in homologous recombination
5888 RAD51 5888 HGNC:9817 Hs.631709 205023_at
205024_s_at
RAD51 homolog (RecA homolog, E. coli) (S. cerevisiae) RAD51 homolog (RecA homolog, E. coli) (S. cerevisiae) ENSG00000051180 ENSP00000267868 hsa+5888 RAD51 RAD51A, RECA RAD51 15q15.1 Approved HsRad51, HsT16930, BRCC5 RAD51 RAD51 homolog (RecA homolog, E. coli) (S. cerevisiae); May participate in a common DNA damage response pathway associated with the activation of homologous recombination and double-strand break repair. Binds to single and double stranded DNA and exhibits DNA-dependent ATPase activity. Underwinds duplex DNA and forms helical nucleoprotein filaments
5883 RAD9A 5883 HGNC:9827 1562022_s_at
204828_at
RAD9 homolog A (S. pombe) ENSG00000172613 ENSP00000311360 RAD9A RAD9 11q13.1-q13.2 Approved RAD9 homolog A (S. pombe); Component of the 9-1-1 cell-cycle checkpoint response complex that plays a major role in DNA repair. The 9-1-1 complex is recruited to DNA lesion upon damage by the RAD17-replication factor C (RFC) clamp loader complex. Acts then as a sliding clamp platform on DNA for several proteins involved in long-patch base excision repair (LP-BER). The 9-1-1 complex stimulates DNA polymerase beta (POLB) activity by increasing its affinity for the 3'-OH end of the primer-template and stabilizes POLB to those sites where LP-BER proceeds; endonuclease FEN1 cleavage activit [...]
5982 RFC2 5982 HGNC:9970 Hs.647062 1053_at
203696_s_at
replication factor C (activator 1) 2, 40kDa Replication factor C (activator 1) 2, 40kDa GO:0006297 ENSG00000049541 ENSP00000055077 hsa+5982 RFC2 RFC2 EXP 7q11.23 Approved A1, RFC40 RFC2 replication factor C (activator 1) 2, 40kDa; The elongation of primed DNA templates by DNA polymerase delta and epsilon requires the action of the accessory proteins proliferating cell nuclear antigen (PCNA) and activator 1. This subunit binds ATP (By similarity)
5983 RFC3 5983 HGNC:9971 Hs.115474 204127_at
204128_s_at
231119_at
replication factor C (activator 1) 3, 38kDa Replication factor C (activator 1) 3, 38kDa GO:0006297 ENSG00000133119 ENSP00000369411 hsa+5983 RFC3 RFC3 EXP 13q13.2 Approved RFC38, MGC5276 RFC3 replication factor C (activator 1) 3, 38kDa; The elongation of primed DNA templates by DNA polymerase delta and epsilon requires the action of the accessory proteins proliferating cell nuclear antigen (PCNA) and activator 1
5984 RFC4 5984 HGNC:9972 Hs.714318 204023_at
replication factor C (activator 1) 4, 37kDa Replication factor C (activator 1) 4, 37kDa GO:0006297 ENSG00000163918 ENSP00000296273 hsa+5984 RFC4 RFC4 EXP 3q27 Approved A1, RFC37 RFC4 replication factor C (activator 1) 4, 37kDa; The elongation of primed DNA templates by DNA polymerase delta and epsilon requires the action of the accessory proteins proliferating cell nuclear antigen (PCNA) and activator 1. This subunit may be involved in the elongation of the multiprimed DNA template
5985 RFC5 5985 HGNC:9973 Hs.506989 203209_at
203210_s_at
replication factor C (activator 1) 5, 36.5kDa Replication factor C (activator 1) 5, 36.5kDa GO:0006297 ENSG00000111445 ENSP00000408295 hsa+5985 RFC5 RFC5 EXP 12q24.3 Approved RFC36 RFC5 replication factor C (activator 1) 5, 36.5kDa; The elongation of primed DNA templates by DNA polymerase delta and epsilon requires the action of the accessory proteins proliferating cell nuclear antigen (PCNA) and activator 1
6117 RPA1 6117 HGNC:10289 Hs.461925 201528_at
201529_s_at
236675_at
replication protein A1, 70kDa Replication protein A1, 70kDa GO:0000718 GO:0006297 ENSG00000132383 ENSP00000254719 hsa+6117 RPA1 RPA1 EXP 17p13.3 Approved REPA1, RPA70, HSSB, RF-A, RP-A MST075 replication protein A1, 70kDa; Plays an essential role in several cellular processes in DNA metabolism including replication, recombination and DNA repair. Binds and subsequently stabilizes single-stranded DNA intermediates and thus prevents complementary DNA from reannealing
6118 RPA2 6118 HGNC:10290 Hs.79411 201756_at
replication protein A2, 32kDa Replication protein A2, 32kDa GO:0000718 GO:0006297 ENSG00000117748 ENSP00000363021 hsa+6118 RPA2 RPA2 EXP 1p35 Approved RPA2 replication protein A2, 32kDa; Required for DNA recombination, repair and replication. The activity of RP-A is mediated by single-stranded DNA binding and protein interactions
50485 SMARCAL1 50485 HGNC:11102 218452_at
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a-like 1 ENSG00000138375 2q35 Approved
23145 SSPO 23145 HGNC:21998 234349_at
SCO-spondin ENSG00000197558 7q36.1 Approved
8914 TIMELESS 8914 HGNC:11813 203046_s_at
215455_at
timeless circadian clock ENSG00000111602 12q13.3 Approved
54962 TIPIN 54962 HGNC:30750 219258_at
TIMELESS interacting protein ENSG00000075131 15q22.31 Approved
11073 TOPBP1 11073 HGNC:17008 202633_at
topoisomerase (DNA) II binding protein 1 ENSG00000163781 TOPBP1 3q22.1 Approved
7529 YWHAB 7529 HGNC:12849 Hs.643544 208743_s_at
217717_s_at
217718_s_at
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide GO:0008633 ENSG00000166913 ENSP00000300161 hsa+7529 YWHAB YWHAB EXP 20q13.1 Approved REACT_578 YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide; Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathway. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. Negative regulator of osteogenesis
7534 YWHAZ 7534 HGNC:12855 200638_s_at
200639_s_at
200640_at
200641_s_at
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta ENSG00000164924 YWHAD 8q22.3 Approved
39 genes found.

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ID ApprovedSymbol EntrezGene HGNC
UniGeneID HugoName UniGeneName GeneOntologyID
ENSG ENSP KEGGID ApprovedSymbol2
PreviousSymbols NCIName Evidence Chromosome
Status Reactome_ID Aliases StringSymbol
StringName Affymetrics


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