NAME: IL8- and CXCR2-mediated signaling events

ID ApprovedSymbol EntrezGene HGNC UniGeneID Affymetrics HugoName UniGeneName GeneOntologyID ENSG ENSP KEGGID ApprovedSymbol2 PreviousSymbols NCIName Evidence Chromosome Status Reactome_ID Aliases StringSymbol StringName
207 AKT1 207 HGNC:391 Hs.525622 207163_s_at
v-akt murine thymoma viral oncogene homolog 1 V-akt murine thymoma viral oncogene homolog 1 GO:0006924 GO:0008633 ENSG00000142208 ENSP00000270202 hsa+207 AKT1 AKT1 EXP IMP 14q32.32-q32.33 Approved REACT_578 RAC, PKB, PRKBA, AKT AKT1 v-akt murine thymoma viral oncogene homolog 1; General protein kinase capable of phosphorylating several known proteins. Phosphorylates TBC1D4. Signals downstream of phosphatidylinositol 3-kinase (PI(3)K) to mediate the effects of various growth factors such as platelet-derived growth factor (PDGF), epidermal growth factor (EGF), insulin and insulin-like growth factor I (IGF-I). Plays a role in glucose transport by mediating insulin-induced translocation of the GLUT4 glucose transporter to the cell surface. Mediates the antiapoptotic effects of IGF-I. Mediates insulin-stimulated protei [...]
408 ARRB1 408 HGNC:711 218832_x_at
222756_s_at
222912_at
arrestin, beta 1 ENSG00000137486 ARR1 11q13 Approved
409 ARRB2 409 HGNC:712 203388_at
arrestin, beta 2 ENSG00000141480 ARR2 17p13 Approved
867 CBL 867 HGNC:1541 206607_at
225231_at
225234_at
229010_at
243475_at
Cbl proto-oncogene, E3 ubiquitin protein ligase ENSG00000110395 CBL2 11q23.3 Approved
3576 CXCL8 3576 HGNC:6025 chemokine (C-X-C motif) ligand 8 ENSG00000169429 IL8 4q13-q21 Approved
3579 CXCR2 3579 HGNC:6027 207008_at
chemokine (C-X-C motif) receptor 2 ENSG00000180871 IL8RB 2q35 Approved
1759 DNM1 1759 HGNC:2972 215116_s_at
217341_at
dynamin 1 ENSG00000106976 DNM 9q34 Approved
1794 DOCK2 1794 HGNC:2988 1554325_at
213160_at
dedicator of cytokinesis 2 ENSG00000134516 5q35.1 Approved
9844 ELMO1 9844 HGNC:16286 204513_s_at
engulfment and cell motility 1 ENSG00000155849 7p14.1 Approved
2268 FGR 2268 HGNC:3697 208438_s_at
feline Gardner-Rasheed sarcoma viral oncogene homolog ENSG00000000938 SRC2 1p36.2-p36.1 Approved
9630 GNA14 9630 HGNC:4382 220108_at
243580_at
guanine nucleotide binding protein (G protein), alpha 14 ENSG00000156049 9q21 Approved
2769 GNA15 2769 HGNC:4383 205349_at
guanine nucleotide binding protein (G protein), alpha 15 (Gq class) 19p13.3 Approved
2771 GNAI2 2771 HGNC:4385 201040_at
guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2 ENSG00000114353 GNAI2B 3p21.31 Approved
2782 GNB1 2782 HGNC:4396 200744_s_at
200745_s_at
200746_s_at
guanine nucleotide binding protein (G protein), beta polypeptide 1 ENSG00000078369 1p36.33 Approved
54331 GNG2 54331 HGNC:4404 1555766_a_at
223943_s_at
224964_s_at
224965_at
guanine nucleotide binding protein (G protein), gamma 2 14q21 Approved
3055 HCK 3055 HGNC:4840 208018_s_at
hemopoietic cell kinase ENSG00000101336 20q11-q12 Approved
4067 LYN 4067 HGNC:6735 202625_at
202626_s_at
210754_s_at
v-yes-1 Yamaguchi sarcoma viral related oncogene homolog ENSG00000254087 8q13 Approved
5170 PDPK1 5170 HGNC:8816 204524_at
221244_s_at
224986_s_at
32029_at
3-phosphoinositide dependent protein kinase 1 ENSG00000140992 16p13.3 Approved
5294 PIK3CG 5294 HGNC:8978 Hs.32942 206369_s_at
206370_at
phosphoinositide-3-kinase, catalytic, gamma polypeptide Phosphoinositide-3-kinase, catalytic, gamma polypeptide ENSG00000105851 ENSP00000352121 hsa+5294 PIK3CG PIK3CG 7q22 Approved PIK3CG phosphoinositide-3-kinase, catalytic, gamma polypeptide; 3-phosphorylates the cellular phosphoinositide PtdIns- 4,5-biphosphate (PtdIns(4,5)P2) to produce PtdIns-3, 4,5- triiphosphate (PtdIns(3,4,5)P3). Links G-protein coupled receptor activation to the secondary messenger PtdIns(3,4,5)P3 production
146850 PIK3R6 146850 HGNC:27101 1558770_a_at
phosphoinositide-3-kinase, regulatory subunit 6 ENSG00000174083 C17orf38 17p13.1 Approved
23236 PLCB1 23236 HGNC:15917 211925_s_at
213222_at
215687_x_at
phospholipase C, beta 1 (phosphoinositide-specific) ENSG00000182621 20p12 Approved
5330 PLCB2 5330 HGNC:9055 204046_at
210388_at
phospholipase C, beta 2 ENSG00000137841 15q15.1 Approved
5331 PLCB3 5331 HGNC:9056 213384_x_at
phospholipase C, beta 3 (phosphatidylinositol-specific) ENSG00000149782 11q13 Approved
5338 PLD2 5338 HGNC:9068 209643_s_at
phospholipase D2 ENSG00000129219 17p13.3 Approved
5515 PPP2CA 5515 HGNC:9299 Hs.483408 208652_at
235502_at
238719_at
protein phosphatase 2 (formerly 2A), catalytic subunit, alpha isoform Protein phosphatase 2 (formerly 2A), catalytic subunit, alpha isoform ENSG00000113575 ENSP00000418447 PPP2CA PPP2CA 5q31.1 Approved PPP2CA protein phosphatase 2 (formerly 2A), catalytic subunit, alpha isoform; PP2A can modulate the activity of phosphorylase B kinase casein kinase 2, mitogen-stimulated S6 kinase, and MAP-2 kinase. Can dephosphorylate SV40 large T antigen and p53. Dephosphorylates SV40 large T antigen, preferentially on serine residues 120, 123, 677, and perhaps 679. The C subunit was most active, followed by the AC form, which was more active than the ABC form, and activity of all three forms was strongly stimulated by manganese, and to a lesser extent by magnesium. Dephosphorylation by the AC form, but no [...]
5518 PPP2R1A 5518 HGNC:9302 200695_at
protein phosphatase 2, regulatory subunit A, alpha ENSG00000105568 ENSP00000324804 PPP2R1A 19q13 Approved PR65A, PP2A-Aalpha protein phosphatase 2 (formerly 2A), regulatory subunit A, alpha isoform; The PR65 subunit of protein phosphatase 2A serves as a scaffolding molecule to coordinate the assembly of the catalytic subunit and a variable regulatory B subunit
5578 PRKCA 5578 HGNC:9393 1560074_at
206923_at
213093_at
215194_at
215195_at
protein kinase C, alpha PKCA 17q22-q24 Approved
5579 PRKCB 5579 HGNC:9395 207957_s_at
209685_s_at
227817_at
227824_at
228795_at
230437_s_at
protein kinase C, beta ENSG00000166501 PRKCB2, PKCB, PRKCB1 16p12 Approved
5582 PRKCG 5582 HGNC:9402 Hs.631564 206270_at
236195_x_at
protein kinase C, gamma Protein kinase C, gamma GO:0032425 ENSG00000126583 ENSP00000263431 PRKCG PKCG, SCA14 PRKCG IDA 19q13.4 Approved PKCC, MGC57564 PRKCG protein kinase C, gamma; This is a calcium-activated, phospholipid-dependent, serine- and threonine-specific enzyme
8766 RAB11A 8766 HGNC:9760 200863_s_at
200864_s_at
234998_at
RAB11A, member RAS oncogene family ENSG00000103769 15q22.31 Approved
5868 RAB5A 5868 HGNC:9783 206113_s_at
209089_at
RAB5A, member RAS oncogene family ENSG00000144566 RAB5 3p24-p22 Approved
7879 RAB7A 7879 HGNC:9788 211960_s_at
211961_s_at
217267_s_at
217268_at
227602_at
RAB7A, member RAS oncogene family ENSG00000075785 RAB7 3q21 Approved
5880 RAC2 5880 HGNC:9802 207419_s_at
213603_s_at
ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2) ENSG00000128340 22q13.1 Approved
7408 VASP 7408 HGNC:12652 202205_at
vasodilator-stimulated phosphoprotein ENSG00000125753 19q13.32 Approved
34 genes found.

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ID ApprovedSymbol EntrezGene HGNC
UniGeneID HugoName UniGeneName GeneOntologyID
ENSG ENSP KEGGID ApprovedSymbol2
PreviousSymbols NCIName Evidence Chromosome
Status Reactome_ID Aliases StringSymbol
StringName Affymetrics


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