NAME: Mitotic M-M/G1 Phases

ID ApprovedSymbol EntrezGene HGNC UniGeneID Affymetrics HugoName UniGeneName GeneOntologyID ENSG ENSP KEGGID ApprovedSymbol2 PreviousSymbols NCIName Evidence Chromosome Status Reactome_ID Aliases StringSymbol StringName
10121 ACTR1A 10121 HGNC:167 200720_s_at
200721_s_at
ARP1 actin-related protein 1 homolog A, centractin alpha (yeast) ENSG00000138107 ENSP00000358921 ACTR1A 10q24 Approved ARP1 ARP1 actin-related protein 1 homolog A, centractin alpha (yeast); Component of a multi-subunit complex involved in microtubule based vesicle motility. It is associated with the centrosome
10142 AKAP9 10142 HGNC:379 Hs.651221 207870_at
210962_s_at
215483_at
A kinase (PRKA) anchor protein (yotiao) 9 A kinase (PRKA) anchor protein (yotiao) 9 ENSG00000127914 ENSP00000348573 AKAP9 AKAP9 7q21-q22 Approved KIAA0803, AKAP350, AKAP450, CG-NAP, YOTIAO, HYPERION, PRKA9, MU-RMS-40.16A AKAP9 A kinase (PRKA) anchor protein (yotiao) 9; Binds to type II regulatory subunits of protein kinase A. Scaffolding protein that assembles several protein kinases and phosphatases on the centrosome and Golgi apparatus. May be required to maintain the integrity of the Golgi apparatus. Isoform 4 is associated with the N-methyl-D-aspartate receptor and is specifically found in the neuromuscular junction (NMJ) as well as in neuronal synapses, suggesting a role in the organization of postsynaptic specializations
7840 ALMS1 7840 HGNC:428 214220_s_at
214221_at
214707_x_at
Alstrom syndrome 1 ENSG00000116127 ENSP00000264448 ALMS1 2p13.1 Approved KIAA0328 Alstrom syndrome 1; Possible role in intracellular trafficking (By similarity)
22994 AZI1 22994 HGNC:29511 5-azacytidine induced 1 ENSG00000141577 ENSP00000393583 AZI1 17q25.3 Approved AZ1, KIAA1118, CEP131 5-azacytidine induced 1; May play a role in spermatogenesis (By similarity)
8900 CCNA1 8900 HGNC:1577 Hs.417050 205899_at
cyclin A1 Cyclin A1 ENSG00000133101 ENSP00000255465 hsa+8900 CCNA1 CCNA1 13q12.3-q13 Approved CCNA1 cyclin A1; May be involved in the control of the cell cycle at the G1/S (start) and G2/M (mitosis) transitions. May primarily function in the control of the germline meiotic cell cycle and additionally in the control of mitotic cell cycle in some somatic cells
890 CCNA2 890 HGNC:1578 Hs.58974 203418_at
213226_at
cyclin A2 Cyclin A2 ENSG00000145386 ENSP00000274026 hsa+890 CCNA2 CCNA, CCN1 CCNA2 4q25-q31 Approved REACT_152 REACT_383 REACT_6850 CCNA2 cyclin A2; Essential for the control of the cell cycle at the G1/S (start) and the G2/M (mitosis) transitions
891 CCNB1 891 HGNC:1579 Hs.23960 214710_s_at
228729_at
cyclin B1 Cyclin B1 ENSG00000134057 ENSP00000256442 hsa+891 CCNB1 CCNB CCNB1 5q12 Approved CCNB1 cyclin B1; Essential for the control of the cell cycle at the G2/M (mitosis) transition
9133 CCNB2 9133 HGNC:1580 Hs.194698 1560161_at
202705_at
232764_at
232768_at
cyclin B2 Cyclin B2 ENSG00000157456 ENSP00000288207 hsa+9133 CCNB2 CCNB2 15q21.3 Approved HsT17299 CCNB2 cyclin B2; Essential for the control of the cell cycle at the G2/M (mitosis) transition
902 CCNH 902 HGNC:1594 Hs.292524 204093_at
cyclin H Cyclin H GO:0000718 ENSG00000134480 ENSP00000256897 hsa+902 CCNH CCNH EXP 5q13.3-q14 Approved CAK, p34, p37 CCNH cyclin H; Regulates CDK7, the catalytic subunit of the CDK- activating kinase (CAK) enzymatic complex. CAK activates the cyclin-associated kinases CDC2/CDK1, CDK2, CDK4 and CDK6 by threonine phosphorylation. CAK complexed to the core-TFIIH basal transcription factor activates RNA polymerase II by serine phosphorylation of the repetitive C-terminus domain (CTD) of its large subunit (POLR2A), allowing its escape from the promoter and elongation of the transcripts. Involved in cell cycle control and in RNA transcription by RNA polymerase II. Its expression and activity are constant throug [...]
983 CDC2 983 HGNC:1722 Hs.334562 203213_at
203214_x_at
210559_s_at
231534_at
cell division cycle 2, G1 to S and G2 to M Cell division cycle 2, G1 to S and G2 to M GO:0006916 ENSG00000170312 ENSP00000362917 hsa+983 CDC2 CDC2 IDA 10q21.2 Approved REACT_152 REACT_1538 REACT_6850 CDC28A ENSG00000170312 cyclin-dependent kinase 1; Plays a key role in the control of the eukaryotic cell cycle. It is required in higher cells for entry into S-phase and mitosis. p34 is a component of the kinase complex that phosphorylates the repetitive C-terminus of RNA polymerase II
993 CDC25A 993 HGNC:1725 Hs.437705 1555772_a_at
204695_at
204696_s_at
cell division cycle 25 homolog A (S. pombe) Cell division cycle 25 homolog A (S. pombe) ENSG00000164045 ENSP00000303706 hsa+993 CDC25A CDC25A 3p21 Approved CDC25A cell division cycle 25 homolog A (S. pombe); Tyrosine protein phosphatase which functions as a dosage-dependent inducer of mitotic progression. Directly dephosphorylates CDC2 and stimulates its kinase activity. Also dephosphorylates CDK2 in complex with cyclin E, in vitro
994 CDC25B 994 HGNC:1726 Hs.153752 201853_s_at
cell division cycle 25 homolog B (S. pombe) Cell division cycle 25 homolog B (S. pombe) ENSG00000101224 ENSP00000245960 hsa+994 CDC25B CDC25B 20p13 Approved CDC25B cell division cycle 25 homolog B (S. pombe); Tyrosine protein phosphatase which functions as a dosage-dependent inducer of mitotic progression. Directly dephosphorylates CDC2 and stimulates its kinase activity. The three isoforms seem to have a different level of activity
995 CDC25C 995 HGNC:1727 Hs.656 205167_s_at
216914_at
217010_s_at
cell division cycle 25 homolog C (S. pombe) Cell division cycle 25 homolog C (S. pombe) ENSG00000158402 ENSP00000321656 hsa+995 CDC25C CDC25 CDC25C 5q31 Approved CDC25C cell division cycle 25 homolog C (S. pombe); Functions as a dosage-dependent inducer in mitotic control. It is a tyrosine protein phosphatase required for progression of the cell cycle. It directly dephosphorylates CDC2 and activate its kinase activity
728642 CDK11A 728642 HGNC:1730 207428_x_at
210474_s_at
211289_x_at
212401_s_at
215329_s_at
cyclin-dependent kinase 11A ENSG00000008128 ENSP00000384442 CDK11A CDC2L3, CDC2L2 1p36.33 Approved PITSLRE, CDK11-p110, CDK11-p58, CDK11-p46, p58GTA cyclin-dependent kinase 11A; Appears to play multiple roles in cell cycle progression, cytokinesis and apoptosis. The p110 isoforms have been suggested to be involved in pre-mRNA splicing, potentially by phosphorylating the splicing protein SFRS7. The p58 isoform may act as a negative regulator of normal cell cycle progression
984 CDK11B 984 HGNC:1729 cyclin-dependent kinase 11B ENSP00000344418 CDK11B CDC2L1 1p36.33 Approved CDK11-p110, CDK11-p58, CDK11-p46 cyclin-dependent kinase 11A; Appears to play multiple roles in cell cycle progression, cytokinesis and apoptosis. The p110 isoforms have been suggested to be involved in pre-mRNA splicing, potentially by phosphorylating the splicing protein SFRS7. The p58 isoform may act as a negative regulator of normal cell cycle progression
1017 CDK2 1017 HGNC:1771 Hs.19192 204252_at
211803_at
211804_s_at
cyclin-dependent kinase 2 Cyclin-dependent kinase 2 ENSG00000123374 ENSP00000266970 hsa+1017 CDK2 CDK2 12q13 Approved CDK2 cyclin-dependent kinase 2; Involved in the control of the cell cycle. Interacts with cyclins A, B1, B3, D, or E. Activity of CDK2 is maximal during S phase and G2
55755 CDK5RAP2 55755 HGNC:18672 220935_s_at
233540_s_at
237418_at
243153_at
CDK5 regulatory subunit associated protein 2 ENSG00000136861 ENSP00000343818 CDK5RAP2 MCPH3 9q33.3 Approved C48, FLJ10867, CEP215 CDK5 regulatory subunit associated protein 2; Potential regulator of CDK5 activity via its interaction with CDK5R1 (By similarity)
1022 CDK7 1022 HGNC:1778 Hs.184298 211297_s_at
cyclin-dependent kinase 7 Cyclin-dependent kinase 7 GO:0000718 ENSG00000134058 ENSP00000256443 hsa+1022 CDK7 CDK7 EXP 5q12.1 Approved CAK1, CDKN7, MO15, STK1 CDK7 cyclin-dependent kinase 7; Cyclin-dependent kinases (CDKs) are activated by the binding to a cyclin and mediate the progression through the cell cycle. Each different complex controls a specific transition between two subsequent phases in the cell cycle. CDK7 is the catalytic subunit of the CDK-activating kinase (CAK) complex, a serine-threonine kinase. CAK activates the cyclin-associated kinases CDC2/CDK1, CDK2, CDK4 and CDK6 by threonine phosphorylation. CAK complexed to the core-TFIIH basal transcription factor activates RNA polymerase II by serine phosphorylation of the repetitive [...]
55835 CENPJ 55835 HGNC:17272 220885_s_at
223513_at
234023_s_at
centromere protein J ENSG00000151849 ENSP00000371308 CENPJ MCPH6 13q12.12 Approved CPAP, BM032, LAP, LIP1, Sas-4, SASS4 centromere protein J; Plays an important role in cell division and centrosome function by participating in centriole duplication. Inhibits microtubule nucleation from the centrosome
11064 CEP110 11064 HGNC:1858 Hs.653263 centrosomal protein 110kDa Centrosomal protein 110kDa ENSG00000119397 ENSP00000238341 CEP110 CEP1 CEP110 9q33.2 Approved CEP110 centrosomal protein 110kDa; Involved in cell cycle progression and cytokinesis. During the late steps of cytokinesis, anchors exocyst and SNARE complexes at the midbody, thereby allowing secretory vesicle- mediated abscission
9662 CEP135 9662 HGNC:29086 206003_at
207286_at
centrosomal protein 135kDa ENSG00000174799 ENSP00000257287 CEP135 KIAA0635, CEP4 4q12 Approved FLJ13621 centrosomal protein 135kDa; Centrosomal protein involved in centriole biogenesis. Acts as a scaffolding protein during early centriole biogenesis. Also required for centriole-centriole cohesion during interphase by acting as a platform protein for CEP250 at the centriole
22995 CEP152 22995 HGNC:29298 215170_s_at
215882_at
237129_at
238535_at
239413_at
centrosomal protein 152kDa ENSP00000382271 CEP152 15q21.1 Approved KIAA0912 centrosomal protein 152kDa
22897 CEP164 22897 HGNC:29182 1558953_s_at
204250_s_at
204251_s_at
centrosomal protein 164kDa ENSG00000110274 ENSP00000278935 CEP164 11q23.3 Approved KIAA1052 centrosomal protein 164kDa; Plays a role in microtubule organization and/or maintenance for the formation of primary cilia (PC), a microtubule-based structure that protrudes from the surface of epithelial cells. Plays a critical role in G2/M checkpoint and nuclear divisions. A key player in the DNA damage-activated ATR/ATM signaling cascade since it is required for the proper phosphorylation of H2AX, RPA,CHK2 and CHK1. Plays a critical role in chromosome segregation, acting as a mediator required for the maintenance of genomic stability through modulation of MDC1, RPA and CHK1
55125 CEP192 55125 HGNC:25515 218827_s_at
centrosomal protein 192kDa ENSP00000317156 CEP192 18p11.21 Approved KIAA1569, FLJ10352 centrosomal protein 192kDa; Required for mitotic centrosome and spindle assembly. Appears to be a major regulator of pericentriolar material (PCM) recruitment, centrosome maturation, and centriole duplication
11190 CEP250 11190 HGNC:1859 Hs.443976 209495_at
210894_s_at
236424_at
centrosomal protein 250kDa Centrosomal protein 250kDa ENSG00000126001 ENSP00000348401 CEP250 CEP2 CEP250 20q11.22 Approved C-NAP1 CEP250 centrosomal protein 250kDa; Probably plays an important role in centrosome cohesion during interphase
80184 CEP290 80184 HGNC:29021 1556850_at
205250_s_at
221683_s_at
centrosomal protein 290kDa ENSP00000308021 CEP290 12q21.33 Approved KIAA0373, FLJ13615, 3H11Ag, rd16, NPHP6, JBTS5, SLSN6, LCA10, MKS4, BBS14, CT87, POC3 centrosomal protein 290kDa; Activates ATF4-mediated transcription. Required for the correct localization of ciliary and phototransduction proteins in retinal photoreceptor cells; may play a role in ciliary transport processes
9702 CEP57 9702 HGNC:30794 203491_s_at
203492_x_at
203493_s_at
203494_s_at
209862_s_at
centrosomal protein 57kDa ENSG00000166037 ENSP00000317902 CEP57 11q21 Approved Translokin, TSP57, KIAA0092 centrosomal protein 57kDa; Centrosomal protein which may be required for microtubule attachment to centrosomes. May act by forming ring- like structures around microtubules. Mediates nuclear translocation and mitogenic activity of the internalized growth factor FGF2 (By similarity)
80254 CEP63 80254 HGNC:25815 219242_at
222151_s_at
233650_at
centrosomal protein 63kDa ENSG00000182923 ENSP00000336524 CEP63 3q22.1 Approved FLJ13386 centrosomal protein 63kDa; Required for normal spindle assembly. Plays a role in DNA damage response: following DNA double strand breaks (DSBs), it is delocalized from centrosomes, leading to inactivate spindle assembly and delay mitotic progression (By similarity)
80321 CEP70 80321 HGNC:29972 1554488_at
1554489_a_at
219036_at
224150_s_at
238154_at
centrosomal protein 70kDa ENSG00000114107 ENSP00000264982 CEP70 3q22.3 Approved BITE, FLJ13036 centrosomal protein 70kDa
55722 CEP72 55722 HGNC:25547 219531_at
centrosomal protein 72kDa ENSG00000112877 ENSP00000264935 CEP72 5p15.33 Approved KIAA1519, FLJ10565 centrosomal protein 72kDa; Involved in the recruitment of key centrosomal proteins to the centrosome. Provides centrosomal microtubule-nucleation activity on the gamma-tubulin ring complexes (gamma-TuRCs) and has critical roles in forming a focused bipolar spindle, which is needed for proper tension generation between sister chromatids. Required for localization of KIZ/C20orf19, AKAP9 and gamma-tubulin ring complexes (gamma-TuRCs)
79959 CEP76 79959 HGNC:25727 219311_at
52285_f_at
centrosomal protein 76kDa ENSG00000101624 ENSP00000262127 CEP76 C18orf9 18p11.21 Approved HsT1705, FLJ12542 centrosomal protein 76kDa; Centrosomal protein involved in regulation of centriole duplication. Required to limit centriole duplication to once per cell cycle by preventing centriole reduplication
84131 CEP78 84131 HGNC:25740 1557985_s_at
228774_at
centrosomal protein 78kDa ENSG00000148019 ENSP00000365782 CEP78 C9orf81 9q21.2 Approved FLJ12643 centrosomal protein 78kDa
1069 CETN2 1069 HGNC:1867 Hs.82794 209194_at
centrin, EF-hand protein, 2 Centrin, EF-hand protein, 2 ENSG00000147400 ENSP00000359300 hsa+1069 CETN2 CALT CETN2 Xq28 Approved CEN2 CETN2 centrin, EF-hand protein, 2; Plays a fundamental role in microtubule-organizing center structure and function. Required for centriole duplication and correct spindle formation. Has a role in regulating cytokinesis and genome stability via cooperation with CALM1 and CEP110
9793 CKAP5 9793 HGNC:28959 Hs.201253 1555278_a_at
212832_s_at
cytoskeleton associated protein 5 Cytoskeleton associated protein 5 ENSG00000175216 ENSP00000346566 CKAP5 CKAP5 11p11.2 Approved ch-TOG, KIAA0097, TOG, TOGp CKAP5 cytoskeleton associated protein 5; Plays a major role in organizing spindle poles
23332 CLASP1 23332 HGNC:17088 Hs.469840 212752_at
240757_at
cytoplasmic linker associated protein 1 Cytoplasmic linker associated protein 1 ENSG00000074054 ENSP00000263710 CLASP1 CLASP1 2q14.2-q14.3 Approved KIAA0622, MAST1 CLASP1 cytoplasmic linker associated protein 1; Microtubule plus-end tracking protein that promotes the stabilization of dynamic microtubules. Required for the polarization of the cytoplasmic microtubule arrays in migrating cells towards the leading edge of the cell. May act at the cell cortex to enhance the frequency of rescue of depolymerizing microtubules by attaching their plus-ends to cortical platforms composed of ERC1 and PHLDB2. This cortical microtubule stabilizing activity is regulated at least in part by phosphatidylinositol 3- kinase signaling. Also performs a similar stabilizing [...]
1453 CSNK1D 1453 HGNC:2452 Hs.631725 207945_s_at
208774_at
casein kinase 1, delta Casein kinase 1, delta ENSG00000141551 ENSP00000324464 CSNK1D CSNK1D 17q25 Approved HCKID CSNK1D casein kinase 1, delta; Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. It can phosphorylate a large number of proteins. Participates in Wnt signaling. Central component of the circadian clock. May act as a negative regulator of circadian rhythmicity by phosphorylating PER1 and PER2. Retains PER1 in the cytoplasm
1454 CSNK1E 1454 HGNC:2453 202332_at
222015_at
225756_at
226858_at
234943_at
casein kinase 1, epsilon ENSG00000213923 ENSP00000352929 CSNK1E 22q13.1 Approved HCKIE casein kinase 1, epsilon; Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. Can phosphorylate a large number of proteins. Participates in Wnt signaling. Phosphorylates DVL1. Central component of the circadian clock. May act as a negative regulator of circadian rhythmicity by phosphorylating PER1 and PER2. Retains PER1 in the cytoplasm. Inhibits cytokine-induced granuloytic differentiation
1639 DCTN1 1639 HGNC:2711 201082_s_at
204296_at
211780_x_at
dynactin 1 ENSG00000204843 ENSP00000354791 DCTN1 2p13 Approved dynactin 1 (p150, glued homolog, Drosophila); Required for the cytoplasmic dynein-driven retrograde movement of vesicles and organelles along microtubules. Dynein- dynactin interaction is a key component of the mechanism of axonal transport of vesicles and organelles
10540 DCTN2 10540 HGNC:2712 Hs.289123 200932_s_at
214384_s_at
232505_at
dynactin 2 (p50) Dynactin 2 (p50) ENSG00000175203 ENSP00000408910 DCTN2 DCTN2 12q13.3 Approved RBP50, DCTN-50 DCTN2 dynactin 2 (p50); Modulates cytoplasmic dynein binding to an organelle, and plays a role in prometaphase chromosome alignment and spindle organization during mitosis. Involved in anchoring microtubules to centrosomes. May play a role in synapse formation during brain development
11258 DCTN3 11258 HGNC:2713 204246_s_at
dynactin 3 (p22) ENSG00000137100 ENSP00000259632 DCTN3 9p13 Approved DCTN-22 dynactin 3 (p22); Together with dynein may be involved in spindle assembly and cytokinesis
1778 DYNC1H1 1778 HGNC:2961 1556831_at
211928_at
229042_s_at
229115_at
236183_at
241084_x_at
244768_at
dynein, cytoplasmic 1, heavy chain 1 ENSP00000348965 DYNC1H1 DNECL, DNCL, DNCH1 14q32.31 Approved Dnchc1, HL-3, p22, DHC1 dynein, cytoplasmic 1, heavy chain 1; Cytoplasmic dynein acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. Dynein has ATPase activity; the force-producing power stroke is thought to occur on release of ADP
1781 DYNC1I2 1781 HGNC:2964 211684_s_at
dynein, cytoplasmic 1, intermediate chain 2 ENSG00000077380 ENSP00000380308 DYNC1I2 DNCI2 2q31.1 Approved dynein, cytoplasmic 1, intermediate chain 2; The intermediate chains seem to help dynein bind to dynactin 150 kDa component
8655 DYNLL1 8655 HGNC:15476 Hs.5120 200703_at
dynein, light chain, LC8-type 1 Dynein, light chain, LC8-type 1 GO:0008633 ENSG00000088986 ENSP00000242577 DYNLL1 DNCL1 DYNLL1 EXP 12q24.23 Approved REACT_578 hdlc1, DLC1, PIN, LC8, DLC8 DYNLL1 dynein, light chain, LC8-type 1; May be involved in some aspects of dynein-related intracellular transport and motility. May play a role in changing or maintaining the spatial distribution of cytoskeletal structures (By similarity)
1869 E2F1 1869 HGNC:3113 Hs.654393 2028_s_at
204947_at
E2F transcription factor 1 E2F transcription factor 1 ENSG00000101412 ENSP00000345571 hsa+1869 E2F1 RBBP3 E2F1 20q11 Approved REACT_152 RBP3 E2F1 E2F transcription factor 1; Transcription activator that binds DNA cooperatively with dp proteins through the E2 recognition site, 5'-TTTC[CG]CGC- 3' found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication. The DRTF1/E2F complex functions in the control of cell-cycle progression from G1 to S phase. E2F-1 binds preferentially RB1 protein, in a cell-cycle dependent manner. It can mediate both cell proliferation and p53-dependent apoptosis
1871 E2F3 1871 HGNC:3115 Hs.269408 Hs.703174 203692_s_at
203693_s_at
E2F transcription factor 3 E2F transcription factor 3 ENSG00000112242 ENSP00000262904 hsa+1871 E2F3 E2F3 6p22 Approved E2F3 E2F transcription factor 3; Transcription activator that binds DNA cooperatively with DP proteins through the E2 recognition site, 5'-TTTC[CG]CGC- 3' found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication. The DRTF1/E2F complex functions in the control of cell-cycle progression from G1 to S phase. E2F-3 binds specifically to RB1 protein, in a cell-cycle dependent manner
11116 FGFR1OP 11116 HGNC:17012 1568678_s_at
205587_at
205588_s_at
214124_x_at
FGFR1 oncogene partner ENSG00000213066 ENSP00000355812 FGFR1OP 6q27 Approved FOP FGFR1 oncogene partner; Required for anchoring microtubules to the centrosomes
55142 HAUS2 55142 HGNC:25530 220071_x_at
228744_at
229181_s_at
229208_at
HAUS augmin-like complex, subunit 2 ENSG00000137814 ENSP00000260372 HAUS2 C15orf25, CEP27 15q15.1 Approved FLJ10460, HsT17025 HAUS augmin-like complex, subunit 2
3320 HSP90AA1 3320 HGNC:5253 Hs.525600 210211_s_at
211968_s_at
211969_at
214328_s_at
heat shock protein 90kDa alpha (cytosolic), class A member 1 Heat shock protein 90kDa alpha (cytosolic), class A member 1 ENSG00000080824 ENSP00000335153 HSP90AA1 HSPC1, HSPCA HSP90AA1 14q32.33 Approved Hsp89, Hsp90, FLJ31884, HSP90N HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1; Molecular chaperone. Has ATPase activity (By similarity)
22919 MAPRE1 22919 HGNC:6890 Hs.472437 200712_s_at
200713_s_at
microtubule-associated protein, RP/EB family, member 1 Microtubule-associated protein, RP/EB family, member 1 ENSG00000101367 ENSP00000364721 MAPRE1 MAPRE1 20q11.1-q11.3 Approved EB1 MAPRE1 microtubule-associated protein, RP/EB family, member 1; May be involved in microtubule polymerization, and spindle function by stabilizing microtubules and anchoring them at centrosomes. May play a role in cell migration
4331 MNAT1 4331 HGNC:7181 Hs.509523 203565_s_at
menage a trois homolog 1, cyclin H assembly factor (Xenopus laevis) Menage a trois homolog 1, cyclin H assembly factor (Xenopus laevis) GO:0000718 ENSG00000020426 ENSP00000261245 hsa+4331 MNAT1 MNAT1 EXP 14q23 Approved MAT1, RNF66 MNAT1 menage a trois homolog 1, cyclin H assembly factor (Xenopus laevis); Stabilizes the cyclin H-CDK7 complex to form a functional CDK-activating kinase (CAK) enzymatic complex. CAK activates the cyclin-associated kinases CDC2/CDK1, CDK2, CDK4 and CDK6 by threonine phosphorylation. CAK complexed to the core-TFIIH basal transcription factor activates RNA polymerase II by serine phosphorylation of the repetitive C-terminus domain (CTD) of its large subunit (POLR2A), allowing its escape from the promoter and elongation of the transcripts. Involved in cell cycle control and in RNA transcriptio [...]
54820 NDE1 54820 HGNC:17619 218414_s_at
222625_s_at
227249_at
227843_at
230219_at
nudE nuclear distribution gene E homolog 1 (A. nidulans) ENSG00000072864 ENSP00000345892 NDE1 16p13.11 Approved NUDE, FLJ20101 microRNA 484; Required for centrosome duplication. Essential for the development of the cerebral cortex. May regulate the production of neurons by controlling the orientation of the mitotic spindle during division of cortical neuronal progenitors of the proliferative ventricular zone of the brain. Orientation of the division plane perpendicular to the layers of the cortex gives rise to two proliferative neuronal progenitors whereas parallel orientation of the division plane yields one proliferative neuronal progenitor and a post-mitotic neuron. A premature shift towards a neuronal fate [...]
121441 NEDD1 121441 HGNC:7723 1552417_a_at
1560116_a_at
234984_at
neural precursor cell expressed, developmentally down-regulated 1 ENSP00000407964 NEDD1 12q23.1 Approved GCP-WD, TUBGCP7 neural precursor cell expressed, developmentally down-regulated 1; Required for mitosis progression. Promotes the nucleation of microtubules from the spindle
4751 NEK2 4751 HGNC:7745 204641_at
211080_s_at
NIMA (never in mitosis gene a)-related kinase 2 ENSG00000117650 ENSP00000355966 NEK2 1q32-q42 Approved NLK1, NEK2A NIMA (never in mitosis gene a)-related kinase 2; Protein kinase that is involved in mitotic regulation. May have a role at the G2-M transition. May also play a role in meiosis. Isoform 1 but not isoform 2 appears to play a role in centrosome splitting. Isoform 1 phosphorylates and activates NEK11 in G1/S-arrested cells. Isoform 2, which is not present in the nucleolus, does not
22981 NINL 22981 HGNC:29163 207705_s_at
ninein-like ENSG00000101004 ENSP00000278886 NINL 20p11.22-p11.1 Approved KIAA0980, NLP ninein-like; Involved in the microtubule organization in interphase cells. Overexpression induces the fragmentation of the Golgi, and causes lysosomes to disperse toward the cell periphery; it also interferes with mitotic spindle assembly. May play a role in ovarian carcinogenesis
4926 NUMA1 4926 HGNC:8059 Hs.325978 nuclear mitotic apparatus protein 1 Nuclear mitotic apparatus protein 1 ENSG00000137497 ENSP00000352675 NUMA1 NUMA1 11q13 Approved NUMA1 nuclear mitotic apparatus protein 1; May be a structural component of the nucleus
4957 ODF2 4957 HGNC:8114 210415_s_at
225617_at
outer dense fiber of sperm tails 2 ENSG00000136811 ENSP00000307781 ODF2 9q34 Approved ODF84, CT134 outer dense fiber of sperm tails 2; Seems to be a major component of sperm tail outer dense fibers (ODF). ODFs are filamentous structures located on the outside of the axoneme in the midpiece and principal piece of the mammalian sperm tail and may help to maintain the passive elastic structures and elastic recoil of the sperm tail. May have a modulating influence on sperm motility. Functions as general scaffold protein that is specifically localized at the distal/subdistal appendages of mother centrioles. Component of the centrosome matrix is required for the localization of PLK1 and N [...]
8481 OFD1 8481 HGNC:2567 203569_s_at
241751_at
oral-facial-digital syndrome 1 ENSG00000046651 ENSP00000344314 OFD1 CXorf5 Xp22 Approved 71-7A, JBTS10 oral-facial-digital syndrome 1; Unknown. May be involved in differentiation of metanephric precursor cells
5048 PAFAH1B1 5048 HGNC:8574 Hs.77318 200813_s_at
200815_s_at
200816_s_at
211547_s_at
platelet-activating factor acetylhydrolase, isoform Ib, subunit 1 (45kDa) Platelet-activating factor acetylhydrolase, isoform Ib, alpha subunit 45kDa ENSG00000007168 ENSP00000380378 PAFAH1B1 MDCR, MDS PAFAH1B1 17p13.3 Approved LIS1, PAFAH PAFAH1B1 platelet-activating factor acetylhydrolase, isoform Ib, subunit 1 (45kDa); Required for proper activation of Rho GTPases and actin polymerization at the leading edge of locomoting cerebellar neurons and postmigratory hippocampal neurons in response to calcium influx triggered via NMDA receptors. Non-catalytic subunit of an acetylhydrolase complex which inactivates platelet- activating factor (PAF) by removing the acetyl group at the SN-2 position (By similarity). Positively regulates the activity of the minus-end directed microtubule motor protein dynein. May enhance dynein-mediated mi [...]
5108 PCM1 5108 HGNC:8727 202174_s_at
209996_x_at
209997_x_at
214118_x_at
214937_x_at
228905_at
pericentriolar material 1 ENSG00000078674 ENSP00000327077 PCM1 8p22-p21.3 Approved PTC4 pericentriolar material 1; Required for centrosome assembly and function. Essential for the correct localization of several centrosomal proteins including CEP250, CETN3, PCNT and NEK2. Required to anchor microtubules to the centrosome
5116 PCNT 5116 HGNC:16068 203660_s_at
233387_s_at
pericentrin ENSG00000160299 ENSP00000352572 PCNT PCNT2 21q22.3 Approved KEN, KIAA0402, PCN, PCNTB, SCKL4 pericentrin; An integral component of the pericentriolar material (PCM)
9088 PKMYT1 9088 HGNC:29650 Hs.77783 204267_x_at
protein kinase, membrane associated tyrosine/threonine 1 Protein kinase, membrane associated tyrosine/threonine 1 ENSG00000127564 ENSP00000262300 hsa+9088 PKMYT1 PKMYT1 16p13.3 Approved MYT1 PKMYT1 protein kinase, membrane associated tyrosine/threonine 1; Acts as a negative regulator of entry into mitosis (G2 to M transition) by phosphorylation of the cdc2 kinase specifically when cdc2 is complexed to cyclins. Mediates phosphorylation of cdc2 predominantly on 'Thr-14'. Also involved in Golgi fragmentation. May be involved in phosphorylation of cdc2 on 'Tyr-15' to a lesser degree, however tyrosine kinase activity is unclear and may be indirect. May be a downstream target of Notch signaling pathway during eye development
5347 PLK1 5347 HGNC:9077 Hs.592049 202240_at
polo-like kinase 1 (Drosophila) Polo-like kinase 1 (Drosophila) ENSG00000166851 ENSP00000300093 hsa+5347 PLK1 PLK PLK1 16p Approved PLK1 polo-like kinase 1 (Drosophila); Serine/threonine-protein kinase that performs several important functions throughout M phase of the cell cycle, including the regulation of centrosome maturation and spindle assembly, the removal of cohesins from chromosome arms, the inactivation of APC/C inhibitors, and the regulation of mitotic exit and cytokinesis
10733 PLK4 10733 HGNC:11397 polo-like kinase 4 ENSG00000142731 ENSP00000270861 PLK4 STK18 4q27-q28 Approved Sak polo-like kinase 4 (Drosophila); Serine/threonine-protein kinase that plays a central role in centriole duplication. Able to trigger procentriole formation on the surface of the parental centriole cylinder, leading to the recruitment of centriole biogenesis proteins such as SASS6, CENPJ/CPAP, CP110, CEP135 and gamma-tubulin. When overexpressed, it is able to induce centrosome amplification through the simultaneous generation of multiple procentrioles adjoining each parental centriole during S phase. Its central role in centriole replication suggests a posible role in tumorigenesis, cen [...]
5518 PPP2R1A 5518 HGNC:9302 200695_at
protein phosphatase 2, regulatory subunit A, alpha ENSG00000105568 ENSP00000324804 PPP2R1A 19q13 Approved PR65A, PP2A-Aalpha protein phosphatase 2 (formerly 2A), regulatory subunit A, alpha isoform; The PR65 subunit of protein phosphatase 2A serves as a scaffolding molecule to coordinate the assembly of the catalytic subunit and a variable regulatory B subunit
5566 PRKACA 5566 HGNC:9380 Hs.631630 202801_at
216234_s_at
protein kinase, cAMP-dependent, catalytic, alpha Protein kinase, cAMP-dependent, catalytic, alpha ENSG00000072062 ENSP00000309591 hsa+5566 PRKACA PRKACA 19p13.1 Approved REACT_1505 REACT_602 PKACa PRKACA protein kinase, cAMP-dependent, catalytic, alpha; Phosphorylates a large number of substrates in the cytoplasm and the nucleus
5577 PRKAR2B 5577 HGNC:9392 Hs.433068 203680_at
protein kinase, cAMP-dependent, regulatory, type II, beta Protein kinase, cAMP-dependent, regulatory, type II, beta ENSG00000005249 ENSP00000265717 hsa+5577 PRKAR2B PRKAR2 PRKAR2B 7q22.3 Approved PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta; Type II regulatory chains mediate membrane association by binding to anchoring proteins, including the MAP2 kinase
10806 SDCCAG8 10806 HGNC:10671 1553034_at
1554237_at
227785_at
243772_at
243963_at
serologically defined colon cancer antigen 8 ENSG00000054282 ENSP00000355499 SDCCAG8 1q43 Approved NY-CO-8, CCCAP, SLSN7, NPHP10, BBS16 serologically defined colon cancer antigen 8
9814 SFI1 9814 HGNC:29064 213431_x_at
214402_s_at
215699_x_at
36545_s_at
Sfi1 homolog, spindle assembly associated (yeast) ENSG00000198089 ENSP00000383145 SFI1 22q12.2 Approved KIAA0542, PISD Sfi1 homolog, spindle assembly associated (yeast); Plays a role in the dynamic structure of centrosome- associated contractile fibers via its interaction with CETN2
8636 SSNA1 8636 HGNC:11321 210378_s_at
Sjogren syndrome nuclear autoantigen 1 ENSG00000176101 ENSP00000313752 SSNA1 9q34.3 Approved NA14, N14 Sjogren syndrome nuclear autoantigen 1
95681 TSGA14 95681 HGNC:12370 testis specific, 14 ENSG00000106477 ENSP00000223208 TSGA14 7q32 Approved DKFZp762H1311, CEP41 testis specific, 14
7846 TUBA1A 7846 HGNC:20766 209118_s_at
tubulin, alpha 1a ENSP00000301071 TUBA1A 12q13.12 Approved TUBA3, B-ALPHA-1, FLJ25113 tubulin, alpha 1a; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha-chain (By similarity)
7277 TUBA4A 7277 HGNC:12407 212242_at
tubulin, alpha 4a ENSG00000127824 ENSP00000248437 TUBA4A TUBA1 2q36.1 Approved FLJ30169, H2-ALPHA tubulin, alpha 4a; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha-chain (By similarity)
203068 TUBB 203068 HGNC:20778 209026_x_at
211714_x_at
212320_at
tubulin, beta ENSG00000196230 ENSP00000410071 TUBB 6p21.33 Approved OK/SW-cl.56, MGC16435, M40, Tubb5 tubulin, beta
10383 TUBB2C 10383 HGNC:20771 tubulin, beta 2C ENSG00000188229 ENSP00000341289 TUBB2C 9q34.3 Approved Beta2 tubulin, beta 2C; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha-chain (By similarity)
10382 TUBB4 10382 HGNC:20774 tubulin, beta 4 ENSG00000104833 ENSP00000264071 TUBB4 19p13.3 Approved beta-5 microRNA 220b; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha-chain (By similarity)
7283 TUBG1 7283 HGNC:12417 201714_at
tubulin, gamma 1 ENSG00000131462 ENSP00000251413 TUBG1 TUBG 17q21.31 Approved TUBGCP1 tubulin, gamma 1; Tubulin is the major constituent of microtubules. Gamma tubulin is found at microtubule organizing centers (MTOC) such as the spindle poles or the centrosome, suggesting that it is involved in the minus-end nucleation of microtubule assembly
27175 TUBG2 27175 HGNC:12419 203894_at
tubulin, gamma 2 ENSP00000251412 TUBG2 17q21.31 Approved tubulin, gamma 2; Tubulin is the major constituent of microtubules. Gamma tubulin is found at microtubule organizing centers (MTOC) such as the spindle poles or the centrosome, suggesting that it is involved in the minus-end nucleation of microtubule assembly
10844 TUBGCP2 10844 HGNC:18599 202476_s_at
202477_s_at
213563_s_at
tubulin, gamma complex associated protein 2 ENSG00000130640 ENSP00000252936 TUBGCP2 10q26.3 Approved GCP2, Spc97p, SPBC97 tubulin, gamma complex associated protein 2; Gamma-tubulin complex is necessary for microtubule nucleation at the centrosome
10426 TUBGCP3 10426 HGNC:18598 1554086_at
203690_at
215739_s_at
tubulin, gamma complex associated protein 3 ENSG00000126216 ENSP00000261965 TUBGCP3 13q34 Approved GCP3, Spc98p, SPBC98 tubulin, gamma complex associated protein 3; Gamma-tubulin complex is necessary for microtubule nucleation at the centrosome
27229 TUBGCP4 27229 HGNC:16691 211337_s_at
213266_at
tubulin, gamma complex associated protein 4 ENSP00000260383 TUBGCP4 15q15 Approved 76P, FLJ14797 tubulin, gamma complex associated protein 4; Gamma-tubulin complex is necessary for microtubule nucleation at the centrosome
114791 TUBGCP5 114791 HGNC:18600 214876_s_at
227967_at
tubulin, gamma complex associated protein 5 ENSG00000153575 ENSP00000283645 TUBGCP5 15q11.1 Approved GCP5, KIAA1899 tubulin, gamma complex associated protein 5; Gamma-tubulin complex is necessary for microtubule nucleation at the centrosome
85378 TUBGCP6 85378 HGNC:18127 225758_s_at
234308_at
tubulin, gamma complex associated protein 6 ENSG00000128159 ENSP00000248846 TUBGCP6 22q13.31-q13.33 Approved GCP6, KIAA1669, DJ402G11.6 tubulin, gamma complex associated protein 6; Gamma-tubulin complex is necessary for microtubule nucleation at the centrosome
7465 WEE1 7465 HGNC:12761 Hs.249441 212533_at
215711_s_at
WEE1 homolog (S. pombe) WEE1 homolog (S. pombe) ENSG00000166483 ENSP00000402084 hsa+7465 WEE1 WEE1 11p15.3-p15.1 Approved WEE1 WEE1 homolog (S. pombe); May act as a negative regulator of entry into mitosis (G2 to M transition) by protecting the nucleus from cytoplasmically activated cyclin B1-complexed CDC2 before the onset of mitosis. Its activity increases during S and G2 phases and decreases at M phase when it is hyperphosphorylated. A correlated decrease in protein level occurs at M/G1 phase, probably due to its degradation. Specifically phosphorylates and inactivates cyclin B1-complexed CDC2 reaching a maximum during G2 phase and a minimum as cells enter M phase. Phosphorylation of cyclin B1-CDC2 occurs e [...]
7514 XPO1 7514 HGNC:12825 Hs.370770 208775_at
235927_at
244012_x_at
exportin 1 (CRM1 homolog, yeast) Exportin 1 (CRM1 homolog, yeast) ENSG00000082898 ENSP00000195419 XPO1 XPO1 2p15 Approved CRM1 exportin 1 (CRM1 homolog, yeast); Mediates the nuclear export of cellular proteins (cargos) bearing a leucine-rich nuclear export signal (NES) and of RNAs. In the nucleus, in association with RANBP3, binds cooperatively to the NES on its target protein and to the GTPase RAN in its active GTP-bound form (Ran-GTP). Docking of this complex to the nuclear pore complex (NPC) is mediated through binding to nucleoporins. Upon transit of an nuclear export complex into the cytoplasm, disassembling of the complex and hydrolysis of Ran-GTP to Ran-GDP (induced by RANBP1 and RANGAP1, respectively) [...]
7531 YWHAE 7531 HGNC:12851 Hs.513851 210317_s_at
210996_s_at
213655_at
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide ENSG00000108953 ENSP00000264335 hsa+7531 YWHAE YWHAE 17p13.3 Approved FLJ45465 YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide; Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathway. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner
7532 YWHAG 7532 HGNC:12852 Hs.520974 222985_at
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide ENSG00000170027 ENSP00000306330 hsa+7532 YWHAG YWHAG 7q11.23 Approved YWHAG tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide; Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathway. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner
86 genes found.

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ID ApprovedSymbol EntrezGene HGNC
UniGeneID HugoName UniGeneName GeneOntologyID
ENSG ENSP KEGGID ApprovedSymbol2
PreviousSymbols NCIName Evidence Chromosome
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