NAME: Mitotic Spindle Checkpoint

ID ApprovedSymbol EntrezGene HGNC UniGeneID Affymetrics HugoName UniGeneName GeneOntologyID ENSG ENSP KEGGID ApprovedSymbol2 PreviousSymbols NCIName Evidence Chromosome Status Reactome_ID Aliases StringSymbol StringName
25909 AHCTF1 25909 HGNC:24618 1560224_at
214766_s_at
226115_at
AT hook containing transcription factor 1 ENSG00000153207 ENSP00000375705 AHCTF1 1q44 Approved ELYS AT hook containing transcription factor 1; Required for the assembly of a functional nuclear pore complex (NPC) on the surface of chromosomes as nuclei form at the end of mitosis. May initiate NPC assembly by binding to chromatin and recruiting the Nup107-160 subcomplex of the NPC. Also required for the localization of the Nup107-160 subcomplex of the NPC to the kinetochore during mitosis and for the completion of cytokinesis
378708 APITD1 378708 HGNC:23163 213454_at
apoptosis-inducing, TAF9-like domain 1 ENSG00000175279 ENSP00000317110 APITD1 1p36.22 Approved CENPS, CENP-S, MHF1, FAAP16 apoptosis-inducing, TAF9-like domain 1; Component of the CENPA-CAD (nucleosome distal) complex, a complex recruited to centromeres which is involved in assembly of kinetochore proteins, mitotic progression and chromosome segregation
9212 AURKB 9212 HGNC:11390 Hs.442658 209464_at
239219_at
aurora kinase B Aurora kinase B ENSG00000178999 ENSP00000313950 AURKB STK12 AURKB 17p13.1 Approved Aik2, IPL1, AurB, AIM-1, ARK2, STK5 AURKB aurora kinase B; May be directly involved in regulating the cleavage of polar spindle microtubules and is a key regulator for the onset of cytokinesis during mitosis. Component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. Phosphorylates 'Ser-10' and 'Ser-28' of histone H3 during mitosis
80776 B9D2 80776 HGNC:28636 219766_at
B9 protein domain 2 ENSP00000243578 B9D2 19q13.2 Approved MGC4093 B9 protein domain 2; May have a role in ciliogenesis (By similarity)
332 BIRC5 332 HGNC:593 Hs.514527 202094_at
202095_s_at
210334_x_at
baculoviral IAP repeat-containing 5 Effector cell peptidase receptor 1 (non-protein coding) GO:0006916 GO:0043154 ENSG00000089685 ENSP00000301633 BIRC5 API4 BIRC5 IDA IMP, IDA 17q25.3 Approved EPR-1 API4 baculoviral IAP repeat-containing 5; Component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. The complex with RAN plays a role in mitotic spindle formation by serving as a physical scaffold to help deliver the RAN effector molecule TPX2 to microtubules. May play a role in neoplasia. May counteract a default induction of apoptosis in G2/M ph [...]
699 BUB1 699 HGNC:1148 Hs.469649 209642_at
215508_at
215509_s_at
216275_at
216277_at
budding uninhibited by benzimidazoles 1 homolog (yeast) BUB1 budding uninhibited by benzimidazoles 1 homolog (yeast) ENSG00000169679 ENSP00000302530 hsa+699 BUB1 BUB1L BUB1 2p11-q21 Approved hBUB1, BUB1A BUB1 budding uninhibited by benzimidazoles 1 homolog (yeast); Involved in cell cycle checkpoint enforcement. Can interact and phosphorylate BUB3
701 BUB1B 701 HGNC:1149 Hs.631699 203755_at
budding uninhibited by benzimidazoles 1 homolog beta (yeast) BUB1 budding uninhibited by benzimidazoles 1 homolog beta (yeast) ENSG00000156970 ENSP00000287598 hsa+701 BUB1B BUB1B 15q15 Approved BUBR1, MAD3L, Bub1A, SSK1 BUB1B budding uninhibited by benzimidazoles 1 homolog beta (yeast); Essential component of the mitotic checkpoint. Required for normal mitosis progression. The mitotic checkpoint delays anaphase until all chromosomes are properly attached to the mitotic spindle. One of its checkpoint functions is to inhibit the activity of the anaphase-promoting complex/cyclosome (APC/C) by blocking the binding of CDC20 to APC/C, independently of its kinase activity. The other is to monitor kinetochore activities that depend on the kinetochore motor CENPE. Negatively regulates PLK1 activity in interphase cel [...]
9184 BUB3 9184 HGNC:1151 Hs.418533 201456_s_at
201457_x_at
201458_s_at
209974_s_at
229827_at
budding uninhibited by benzimidazoles 3 homolog (yeast) BUB3 budding uninhibited by benzimidazoles 3 homolog (yeast) ENSG00000154473 ENSP00000357858 hsa+9184 BUB3 BUB3 10q24 Approved BUB3L BUB3 budding uninhibited by benzimidazoles 3 homolog (yeast); Required for kinetochore localization of BUB1
57082 CASC5 57082 HGNC:24054 1552680_a_at
1552682_a_at
220247_at
228323_at
cancer susceptibility candidate 5 ENSG00000137812 ENSP00000335463 CASC5 15q14 Approved D40, AF15Q14, CT29, hKNL-1, KNL1, hSpc105 cancer susceptibility candidate 5; Part of the MIS12 complex, which may be fundamental for kinetochore formation and proper chromosome segregation during mitosis. Acts in coordination with CENPK to recruit the NDC80 complex to the outer kinetochore
54908 CCDC99 54908 HGNC:26010 coiled-coil domain containing 99 ENSG00000040275 ENSP00000265295 CCDC99 5q35.1 Approved FLJ20364 coiled-coil domain containing 99; Required for the localization of dynein and dynactin to the mitotic kintochore. Dynein is believed to control the initial lateral interaction between the kinetochore and spindle microtubules and to facilitate the subsequent formation of end-on kinetochore-microtubule attachments mediated by the NDC80 complex. Also required for correct spindle orientation. Does not appear to be required for the removal of spindle assembly checkpoint (SAC) proteins from the kinetochore upon bipolar spindle attachment
991 CDC20 991 HGNC:1723 Hs.524947 202870_s_at
cell division cycle 20 homolog (S. cerevisiae) Cell division cycle 20 homolog (S. cerevisiae) ENSG00000117399 ENSP00000308450 hsa+991 CDC20 CDC20 1p34.1 Approved p55CDC, CDC20A CDC20 cell division cycle 20 homolog (S. cerevisiae); Required for full ubiquitin ligase activity of the anaphase promoting complex/cyclosome (APC/C) and may confer substrate specificity upon the complex. Is regulated by MAD2L1. In metaphase the MAD2L1-CDC20-APC/C ternary complex is inactive and in anaphase the CDC20-APC/C binary complex is active in degrading substrates
8318 CDC45L 8318 HGNC:1739 Hs.474217 204126_s_at
CDC45 cell division cycle 45-like (S. cerevisiae) CDC45 cell division cycle 45-like (S. cerevisiae) ENSG00000093009 ENSP00000263201 hsa+8318 CDC45L CDC45L2 CDC45L 22q11.21 Approved CDC45L CDC45 cell division cycle 45-like (S. cerevisiae); Required for initiation of chromosomal DNA replication
990 CDC6 990 HGNC:1744 Hs.405958 203967_at
203968_s_at
cell division cycle 6 homolog (S. cerevisiae) Cell division cycle 6 homolog (S. cerevisiae) ENSG00000094804 ENSP00000209728 hsa+990 CDC6 CDC18L CDC6 17q21.3 Approved CDC6 cell division cycle 6 homolog (S. cerevisiae); Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated
8317 CDC7 8317 HGNC:1745 Hs.533573 204510_at
cell division cycle 7 homolog (S. cerevisiae) Cell division cycle 7 homolog (S. cerevisiae) ENSG00000097046 ENSP00000234626 hsa+8317 CDC7 CDC7L1 CDC7 1p22 Approved Hsk1, huCdc7, HsCdc7 CDC7 cell division cycle 7 homolog (S. cerevisiae); Seems to phosphorylate critical substrates that regulate the G1/S phase transition and/or DNA replication. Can phosphorylates MCM2 and MCM3
55143 CDCA8 55143 HGNC:14629 Hs.524571 221520_s_at
cell division cycle associated 8 Cell division cycle associated 8 ENSG00000134690 ENSP00000316121 CDCA8 CDCA8 1p34.3 Approved FLJ12042 CDCA8 cell division cycle associated 8; Component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. In the complex, it may be required to direct the CPC to centromeric DNA. Major effector of the TTK kinase in the control of attachment-error-correction and chromosome alignment
1017 CDK2 1017 HGNC:1771 Hs.19192 204252_at
211803_at
211804_s_at
cyclin-dependent kinase 2 Cyclin-dependent kinase 2 ENSG00000123374 ENSP00000266970 hsa+1017 CDK2 CDK2 12q13 Approved CDK2 cyclin-dependent kinase 2; Involved in the control of the cell cycle. Interacts with cyclins A, B1, B3, D, or E. Activity of CDK2 is maximal during S phase and G2
81620 CDT1 81620 HGNC:24576 Hs.122908 209832_s_at
228868_x_at
chromatin licensing and DNA replication factor 1 Chromatin licensing and DNA replication factor 1 ENSG00000167513 ENSP00000301019 CDT1 CDT1 16q24.3 Approved DUP, RIS2 CDT1 chromatin licensing and DNA replication factor 1; Cooperates with CDC6 to promote the loading of the mini- chromosome maintenance complex onto chromatin to form the pre- replication complex necessary to initiate DNA replication. Binds DNA in a sequence-, strand-, and conformation-independent manner. Potential oncogene
1058 CENPA 1058 HGNC:1851 204962_s_at
210821_x_at
centromere protein A ENSG00000115163 ENSP00000336868 CENPA 2p24-p21 Approved CENP-A centromere protein A; Histone H3-like variant which exclusively replaces conventional H3 in the nucleosome core of centromeric chromatin at the inner plate of the kinetochore. Required for recruitment and assembly of kinetochore proteins, mitotic progression and chromosome segregation. May serve as an epigenetic mark that propagates centromere identity through replication and cell division
1060 CENPC1 1060 HGNC:1854 centromere protein C 1 ENSG00000145241 ENSP00000273853 CENPC1 4q13.2 Approved CENPC, CENP-C, hcp-4, MIF2 centromere protein C 1; Component of the CENPA-NAC (nucleosome-associated) complex, a complex that plays a central role in assembly of kinetochore proteins, mitotic progression and chromosome segregation. The CENPA-NAC complex recruits the CENPA-CAD (nucleosome distal) complex and may be involved in incorporation of newly synthesized CENPA into centromeres. CENPC recruits DNA methylation and DNMT3B to both centromeric and pericentromeric satellite repeats and regulates the histone code in these regions
1062 CENPE 1062 HGNC:1856 Hs.75573 205046_at
centromere protein E, 312kDa Centromere protein E, 312kDa ENSG00000138778 ENSP00000265148 CENPE CENPE 4q24-q25 Approved KIF10 KIF10 centromere protein E, 312kDa; Essential for the maintenance of chromosomal stability through efficient stabilization of microtubule capture at kinetochores. Plays a key role in the movement of chromosomes toward the metaphase plate during mitosis. Is a slow plus end- directed motor whose activity is essential for metaphase chromosome alignment. Couples chromosome position to microtubule depolymerizing activity. The highly processive microtubule- dependent motor activity of CENPE serves to power chromosome congression and provides a flexible, motile tether linking kinetochores to dynami [...]
1063 CENPF 1063 HGNC:1857 Hs.497741 207828_s_at
209172_s_at
centromere protein F, 350/400ka (mitosin) Centromere protein F, 350/400ka (mitosin) ENSG00000117724 ENSP00000355922 CENPF CENPF 1q32-q41 Approved hcp-1 CENPF centromere protein F, 350/400ka (mitosin); Required for kinetochore function and chromosome segregation in mitosis. Required for kinetochore localization of dynein, LIS1, NDE1 and NDEL1. Regulates recycling of the plasma membrane by acting as a link between recycling vesicles and the microtubule network though its association with STX4 and SNAP25. Acts as a potential inhibitor of pocket protein-mediated cellular processes during development by regulating the activity of RB proteins during cell division and proliferation. May play a regulatory or permissive role in the normal embryonic [...]
64946 CENPH 64946 HGNC:17268 Hs.631967 231772_x_at
centromere protein H Centromere protein H ENSG00000153044 ENSP00000283006 CENPH CENPH 5p15.2 Approved NNF1, PMF1 CENPH centromere protein H; Component of the CENPA-NAC (nucleosome-associated) complex, a complex that plays a central role in assembly of kinetochore proteins, mitotic progression and chromosome segregation. The CENPA-NAC complex recruits the CENPA-CAD (nucleosome distal) complex and may be involved in incorporation of newly synthesized CENPA into centromeres. Required for chromosome congression and efficiently align the chromosomes on a metaphase plate
2491 CENPI 2491 HGNC:3968 1555046_at
1563223_a_at
207590_s_at
214804_at
centromere protein I ENSG00000102384 ENSP00000218507 CENPI FSHPRH1 Xq22.1 Approved LRPR1, CENP-I, Mis6 centromere protein I; Component of the CENPA-CAD (nucleosome distal) complex, a complex recruited to centromeres which is involved in assembly of kinetochore proteins, mitotic progression and chromosome segregation. May be involved in incorporation of newly synthesized CENPA into centromeres via its interaction with the CENPA-NAC complex. Required for the localization of CENPF, MAD1L1 and MAD2 (MAD2L1 or MAD2L2) to kinetochores. Involved in the response of gonadal tissues to follicle-stimulating hormone
64105 CENPK 64105 HGNC:29479 Hs.529778 222848_at
centromere protein K Centromere protein K ENSG00000123219 ENSP00000242872 CENPK CENPK 5q12.3 Approved FKSG14, SOLT, CENP-K CENPK centromere protein K; Component of the CENPA-CAD (nucleosome distal) complex, a complex recruited to centromeres which is involved in assembly of kinetochore proteins, mitotic progression and chromosome segregation. May be involved in incorporation of newly synthesized CENPA into centromeres via its interaction with the CENPA-NAC complex. Acts in coordination with CASC5/KNL1 to recruit the NDC80 complex to the outer kinetochore
91687 CENPL 91687 HGNC:17879 1554271_a_at
232065_x_at
centromere protein L ENSG00000120334 ENSP00000348527 CENPL C1orf155 1q25.1 Approved dJ383J4.3, FLJ31044 centromere protein L; Component of the CENPA-CAD (nucleosome distal) complex, a complex recruited to centromeres which is involved in assembly of kinetochore proteins, mitotic progression and chromosome segregation. May be involved in incorporation of newly synthesized CENPA into centromeres via its interaction with the CENPA-NAC complex
79019 CENPM 79019 HGNC:18352 218741_at
centromere protein M ENSG00000100162 ENSP00000215980 CENPM C22orf18 22q13.2 Approved Pane1, CENP-M, MGC861 centromere protein M; Component of the CENPA-NAC (nucleosome-associated) complex, a complex that plays a central role in assembly of kinetochore proteins, mitotic progression and chromosome segregation. The CENPA-NAC complex recruits the CENPA-CAD (nucleosome distal) complex and may be involved in incorporation of newly synthesized CENPA into centromeres
55839 CENPN 55839 HGNC:30873 219555_s_at
222118_at
228559_at
234811_at
centromere protein N ENSG00000166451 ENSP00000377007 CENPN C16orf60 16q23.2 Approved FLJ13607, FLJ22660, BM039 centromere protein N; Component of the CENPA-NAC (nucleosome-associated) complex, a complex that plays a central role in assembly of kinetochore proteins, mitotic progression and chromosome segregation. The CENPA-NAC complex recruits the CENPA-CAD (nucleosome distal) complex and may be involved in incorporation of newly synthesized CENPA into centromeres. CENPN is the first protein to bind specifically to CENPA nucleosomes and the direct binding of CENPA nucleosomes by CENPN is required for centromere assembly. Required for chromosome congression and efficiently align the chromosomes o [...]
79172 CENPO 79172 HGNC:28152 219472_at
226118_at
centromere protein O ENSG00000138092 ENSP00000260662 CENPO 2p23.3 Approved MGC11266, CENP-O centromere protein O; Component of the CENPA-CAD (nucleosome distal) complex, a complex recruited to centromeres which is involved in assembly of kinetochore proteins, mitotic progression and chromosome segregation. May be involved in incorporation of newly synthesized CENPA into centromeres via its interaction with the CENPA-NAC complex. Modulates the kinetochore-bound levels of NDC80 complex
401541 CENPP 401541 HGNC:32933 242207_at
centromere protein P ENSG00000188312 ENSP00000364737 CENPP 9q22.31 Approved RP11-19J3.3, CENP-P centromere protein P; Component of the CENPA-CAD (nucleosome distal) complex, a complex recruited to centromeres which is involved in assembly of kinetochore proteins, mitotic progression and chromosome segregation. May be involved in incorporation of newly synthesized CENPA into centromeres via its interaction with the CENPA-NAC complex
55166 CENPQ 55166 HGNC:21347 219294_at
centromere protein Q ENSG00000031691 ENSP00000337289 CENPQ C6orf139 6p12.3 Approved FLJ10545, CENP-Q centromere protein Q; Component of the CENPA-CAD (nucleosome distal) complex, a complex recruited to centromeres which is involved in assembly of kinetochore proteins, mitotic progression and chromosome segregation. May be involved in incorporation of newly synthesized CENPA into centromeres via its interaction with the CENPA-NAC complex
80152 CENPT 80152 HGNC:25787 218148_at
centromere protein T ENSP00000219172 CENPT C16orf56 16q22.1 Approved FLJ13111, CENP-T centromere protein T; Component of the CENPA-NAC (nucleosome-associated) complex, a complex that plays a central role in assembly of kinetochore proteins, mitotic progression and chromosome segregation. The CENPA-NAC complex recruits the CENPA-CAD (nucleosome distal) complex and may be involved in incorporation of newly synthesized CENPA into centromeres. CENP-T is one of the basic inner kinetochore proteins with most further proteins binding downstream, suggesting a fundamental role of CENP-T in kinetochore function
9793 CKAP5 9793 HGNC:28959 Hs.201253 1555278_a_at
212832_s_at
cytoskeleton associated protein 5 Cytoskeleton associated protein 5 ENSG00000175216 ENSP00000346566 CKAP5 CKAP5 11p11.2 Approved ch-TOG, KIAA0097, TOG, TOGp CKAP5 cytoskeleton associated protein 5; Plays a major role in organizing spindle poles
23332 CLASP1 23332 HGNC:17088 Hs.469840 212752_at
240757_at
cytoplasmic linker associated protein 1 Cytoplasmic linker associated protein 1 ENSG00000074054 ENSP00000263710 CLASP1 CLASP1 2q14.2-q14.3 Approved KIAA0622, MAST1 CLASP1 cytoplasmic linker associated protein 1; Microtubule plus-end tracking protein that promotes the stabilization of dynamic microtubules. Required for the polarization of the cytoplasmic microtubule arrays in migrating cells towards the leading edge of the cell. May act at the cell cortex to enhance the frequency of rescue of depolymerizing microtubules by attaching their plus-ends to cortical platforms composed of ERC1 and PHLDB2. This cortical microtubule stabilizing activity is regulated at least in part by phosphatidylinositol 3- kinase signaling. Also performs a similar stabilizing [...]
23122 CLASP2 23122 HGNC:17078 1555469_a_at
1558759_s_at
212306_at
212308_at
212309_at
238048_at
cytoplasmic linker associated protein 2 ENSG00000163539 ENSP00000352581 CLASP2 3p24.3 Approved KIAA0627 cytoplasmic linker associated protein 2; Microtubule plus-end tracking protein that promotes the stabilization of dynamic microtubules. Required for the polarization of the cytoplasmic microtubule arrays in migrating cells towards the leading edge of the cell. May act at the cell cortex to enhance the frequency of rescue of depolymerizing microtubules by attaching their plus-ends to cortical platforms composed of ERC1 and PHLDB2. This cortical microtubule stabilizing activity is regulated at least in part by phosphatidylinositol 3- kinase signaling. Also performs a similar stabilizing [...]
6249 CLIP1 6249 HGNC:10461 1558924_s_at
1568012_at
201975_at
210716_s_at
240444_x_at
242287_at
CAP-GLY domain containing linker protein 1 ENSG00000130779 ENSP00000351665 CLIP1 RSN 12q24.3 Approved CYLN1, CLIP170, CLIP, CLIP-170 CAP-GLY domain containing linker protein 1; Seems to be a intermediate filament associated protein that links endocytic vesicles to microtubules
10926 DBF4 10926 HGNC:17364 Hs.485380 204244_s_at
DBF4 homolog (S. cerevisiae) DBF4 homolog (S. cerevisiae) ENSG00000006634 ENSP00000265728 hsa+10926 DBF4 DBF4 7q21.3 Approved ASK, DBF4A, chif, ZDBF1 DBF4 DBF4 homolog (S. cerevisiae); Regulatory subunit for CDC7 which activates its kinase activity thereby playing a central role in DNA replication and cell proliferation. Required for progression of S phase. The complex CDC7-DBF4A selectively phosphorylates MCM2 subunit at 'Ser-40' and 'Ser-53' and then is involved in regulating the initiation of DNA replication during cell cycle
79980 DSN1 79980 HGNC:16165 219512_at
DSN1, MIND kinetochore complex component, homolog (S. cerevisiae) ENSG00000149636 ENSP00000362850 DSN1 C20orf172 20q11.23 Approved dJ469A13.2, MIS13, KNL3, hKNL-3 DSN1, MIND kinetochore complex component, homolog (S. cerevisiae); Part of the MIS12 complex which is required for normal chromosome alignment and segregation and kinetochore formation during mitosis
1869 E2F1 1869 HGNC:3113 Hs.654393 2028_s_at
204947_at
E2F transcription factor 1 E2F transcription factor 1 ENSG00000101412 ENSP00000345571 hsa+1869 E2F1 RBBP3 E2F1 20q11 Approved REACT_152 RBP3 E2F1 E2F transcription factor 1; Transcription activator that binds DNA cooperatively with dp proteins through the E2 recognition site, 5'-TTTC[CG]CGC- 3' found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication. The DRTF1/E2F complex functions in the control of cell-cycle progression from G1 to S phase. E2F-1 binds preferentially RB1 protein, in a cell-cycle dependent manner. It can mediate both cell proliferation and p53-dependent apoptosis
1870 E2F2 1870 HGNC:3114 Hs.194333 207042_at
228361_at
235582_at
E2F transcription factor 2 E2F transcription factor 2 ENSG00000007968 ENSP00000355249 hsa+1870 E2F2 E2F2 1p36 Approved E2F-2 E2F2 E2F transcription factor 2; Transcription activator that binds DNA cooperatively with DP proteins through the E2 recognition site, 5'-TTTC[CG]CGC- 3' found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication. The DRTF1/E2F complex functions in the control of cell-cycle progression from g1 to s phase. E2F-2 binds specifically to RB1 protein, in a cell-cycle dependent manner
1871 E2F3 1871 HGNC:3115 Hs.269408 Hs.703174 203692_s_at
203693_s_at
E2F transcription factor 3 E2F transcription factor 3 ENSG00000112242 ENSP00000262904 hsa+1871 E2F3 E2F3 6p22 Approved E2F3 E2F transcription factor 3; Transcription activator that binds DNA cooperatively with DP proteins through the E2 recognition site, 5'-TTTC[CG]CGC- 3' found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication. The DRTF1/E2F complex functions in the control of cell-cycle progression from G1 to S phase. E2F-3 binds specifically to RB1 protein, in a cell-cycle dependent manner
54821 ERCC6L 54821 HGNC:20794 219650_at
excision repair cross-complementing rodent repair deficiency, complementation group 6-like ENSG00000186871 ENSP00000334675 ERCC6L Xq13.1 Approved FLJ20105 excision repair cross-complementing rodent repair deficiency, complementation group 6-like; DNA helicase that acts as an essential component of the spindle assembly checkpoint. Contributes to the mitotic checkpoint by recruiting MAD2 to kinetochores and monitoring tension on centromeric chromatin. Acts as a tension sensor that associates with catenated DNA which is stretched under tension until it is resolved during anaphase
26271 FBXO5 26271 HGNC:13584 Hs.520506 218875_s_at
234863_x_at
F-box protein 5 F-box protein 5 ENSG00000112029 ENSP00000229758 FBXO5 FBXO5 6q25-q26 Approved FBX5, Fbxo31, EMI1 FBXO5 F-box protein 5; Regulates progression through early mitosis by inhibiting the anaphase promoting complex/cyclosome (APC). Binds to the APC activators CDC20 and FZR1/CDH1 to prevent APC activation. Can also bind directly to the APC to inhibit substrate-binding
51053 GMNN 51053 HGNC:17493 Hs.234896 218350_s_at
geminin, DNA replication inhibitor Geminin, DNA replication inhibitor ENSG00000112312 ENSP00000230056 GMNN GMNN 6p21.32 Approved Gem GMNN geminin, DNA replication inhibitor; Inhibits DNA replication by preventing the incorporation of MCM complex into prereplication complex (pre-RC). It is degraded during the mitotic phase of the cell cycle. Its destruction at the metaphase-anaphase transition permits replication in the succeeding cell cycle
64689 GORASP1 64689 HGNC:16769 215749_s_at
243677_at
golgi reassembly stacking protein 1, 65kDa ENSG00000114745 ENSP00000313869 GORASP1 GOLPH5 3p22-p21.33 Approved GRASP65, P65, FLJ23443 golgi reassembly stacking protein 1, 65kDa; Stacking factor involved in the postmitotic assembly of Golgi stacks from mitotic Golgi fragments. Key structural protein required for the maintenance of the Golgi apparatus integrity: its caspase-mediated cleavage is required for fragmentation of the Golgi during apoptosis. Also mediates, via its interaction with GM130, the docking of transport vesicles with the Golgi membranes
3619 INCENP 3619 HGNC:6058 Hs.142179 219769_at
inner centromere protein antigens 135/155kDa Inner centromere protein antigens 135/155kDa ENSG00000149503 ENSP00000378295 INCENP INCENP 11q12.3 Approved FLJ31633 INCENP inner centromere protein antigens 135/155kDa; Component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. Probably acts through association with AURKB or AURKC. Seems to bind directly to microtubules
23421 ITGB3BP 23421 HGNC:6157 205176_s_at
integrin beta 3 binding protein (beta3-endonexin) ENSG00000142856 ENSP00000271002 ITGB3BP 1p31.3 Approved NRIF3, HSU37139, TAP20, CENPR integrin beta 3 binding protein (beta3-endonexin); Transcription coregulator that can have both coactivator and corepressor functions. Isoform 1, but not other isoforms, is involved in the coactivation of nuclear receptors for retinoid X (RXRs) and thyroid hormone (TRs) in a ligand-dependent fashion. In contrast, it does not coactivate nuclear receptors for retinoic acid, vitamin D, progesterone receptor, nor glucocorticoid. Acts as a coactivator for estrogen receptor alpha. Acts as a transcriptional corepressor via its interaction with the NFKB1 NF- kappa-B subunit, possibly by interf [...]
81930 KIF18A 81930 HGNC:29441 221258_s_at
kinesin family member 18A ENSG00000121621 ENSP00000263181 KIF18A 11p14.1 Approved DKFZP434G2226 kinesin family member 18A; Microtubule-depolymerizing kinesin which plays a role in chromosome congression by reducing the amplitude of preanaphase oscillations and slowing poleward movement during anaphase, thus suppressing chromosome movements. May stabilize the CENPE-BUB1B complex at the kinetochores during early mitosis and maintains CENPE levels at kinetochores during chromosome congression
10112 KIF20A 10112 HGNC:9787 218755_at
kinesin family member 20A ENSG00000112984 ENSP00000378356 KIF20A RAB6KIFL 5q31 Approved kinesin family member 20A; Interacts with guanosine triphosphate (GTP)-bound forms of RAB6A and RAB6B. May act as a motor required for the retrograde RAB6 regulated transport of Golgi membranes and associated vesicles along microtubules. Has a microtubule plus end-directed motility (By similarity)
9493 KIF23 9493 HGNC:6392 204709_s_at
244427_at
kinesin family member 23 ENSP00000260363 KIF23 KNSL5 15q23 Approved MKLP1, MKLP-1 kinesin family member 23; Plus-end-directed motor enzyme that moves antiparallel microtubules in vitro. Localizes to the interzone of mitotic spindles
3796 KIF2A 3796 HGNC:6318 203086_at
203087_s_at
220699_s_at
kinesin heavy chain member 2A ENSG00000068796 ENSP00000385000 KIF2A KIF2 5q12-q13 Approved HK2 kinesin heavy chain member 2A; Plus end-directed microtubule-dependent motor required for normal brain development. May regulate microtubule dynamics during axonal growth. Implicated in formation of bipolar mitotic spindles. Has microtubule depolymerization activity
84643 KIF2B 84643 HGNC:29443 223926_at
kinesin family member 2B ENSP00000268919 KIF2B 17q22 Approved kinesin family member 2B; Plus end-directed microtubule-dependent motor required for spindle assembly and chromosome movement. Has microtubule depolymerization activity
11004 KIF2C 11004 HGNC:6393 209408_at
211519_s_at
kinesin family member 2C ENSG00000142945 ENSP00000361298 KIF2C KNSL6 1p34.1 Approved MCAK kinesin family member 2C; Promotes ATP-dependent removal of tubulin dimers from microtubules. Regulates the turnover of microtubules at the kinetochore and functions in chromosome segregation during mitosis
9735 KNTC1 9735 HGNC:17255 Hs.300559 206316_s_at
kinetochore associated 1 Kinetochore associated 1 ENSG00000184445 ENSP00000328236 KNTC1 KNTC1 12q24.31 Approved KIAA0166, ROD ROD kinetochore associated 1; Essential component of the mitotic checkpoint, which prevents cells from prematurely exiting mitosis. Required for the assembly of the dynein-dynactin and MAD1-MAD2 complexes onto kinetochores
8379 MAD1L1 8379 HGNC:6762 Hs.654838 204857_at
MAD1 mitotic arrest deficient-like 1 (yeast) MAD1 mitotic arrest deficient-like 1 (yeast) ENSG00000002822 ENSP00000382562 hsa+8379 MAD1L1 MAD1L1 7p22 Approved HsMAD1, TXBP181, MAD1, PIG9, TP53I9 MAD1 MAD1 mitotic arrest deficient-like 1 (yeast); Component of the spindle-assembly checkpoint that prevents the onset of anaphase until all chromosomes are properly aligned at the metaphase plate. May recruit MAD2L1 to unattached kinetochores. Has a role in the correct positioning of the septum. Required for anchoring MAD2L1 to the nuclear periphery
4085 MAD2L1 4085 HGNC:6763 Hs.591697 1554768_a_at
203362_s_at
MAD2 mitotic arrest deficient-like 1 (yeast) MAD2 mitotic arrest deficient-like 1 (yeast) ENSG00000164109 ENSP00000296509 hsa+4085 MAD2L1 MAD2L1 4q27 Approved MAD2, HSMAD2 MAD2 MAD2 mitotic arrest deficient-like 1 (yeast); Component of the spindle-assembly checkpoint that prevents the onset of anaphase until all chromosomes are properly aligned at the metaphase plate. Required for the execution of the mitotic checkpoint which monitors the process of kinetochore- spindle attachment and inhibits the activity of the anaphase promoting complex by sequestering CDC20 until all chromosomes are aligned at the metaphase plate
22919 MAPRE1 22919 HGNC:6890 Hs.472437 200712_s_at
200713_s_at
microtubule-associated protein, RP/EB family, member 1 Microtubule-associated protein, RP/EB family, member 1 ENSG00000101367 ENSP00000364721 MAPRE1 MAPRE1 20q11.1-q11.3 Approved EB1 MAPRE1 microtubule-associated protein, RP/EB family, member 1; May be involved in microtubule polymerization, and spindle function by stabilizing microtubules and anchoring them at centrosomes. May play a role in cell migration
55388 MCM10 55388 HGNC:18043 Hs.198363 220651_s_at
222962_s_at
223570_at
minichromosome maintenance complex component 10 Minichromosome maintenance complex component 10 ENSG00000065328 ENSP00000354945 MCM10 MCM10 10p13 Approved PRO2249, CNA43, DNA43 MCM10 minichromosome maintenance complex component 10; Acts as a replication initiation factor that brings together the MCM2-7 helicase and the DNA polymerase alpha/primase complex in order to initiate DNA replication. Additionally, plays a role in preventing DNA damage during replication
4171 MCM2 4171 HGNC:6944 Hs.477481 202107_s_at
minichromosome maintenance complex component 2 Minichromosome maintenance complex component 2 ENSG00000073111 ENSP00000265056 hsa+4171 MCM2 CCNL1, CDCL1 MCM2 3q21 Approved D3S3194, KIAA0030, BM28, cdc19 BM28 minichromosome maintenance complex component 2; Acts as a factor that allows the DNA to undergo a single round of replication per cell cycle. Required for the entry in S phase and for cell division
4172 MCM3 4172 HGNC:6945 Hs.179565 201555_at
minichromosome maintenance complex component 3 Minichromosome maintenance complex component 3 ENSG00000112118 ENSP00000229854 hsa+4172 MCM3 MCM3 6p12 Approved MCM3 minichromosome maintenance complex component 3; Acts as a factor that allows the DNA to undergo a single round of replication per cell cycle. Required for DNA replication and cell proliferation
4173 MCM4 4173 HGNC:6947 Hs.460184 212141_at
212142_at
222036_s_at
222037_at
minichromosome maintenance complex component 4 Minichromosome maintenance complex component 4 ENSG00000104738 ENSP00000262105 hsa+4173 MCM4 CDC21 MCM4 8q12-q13 Approved CDC54, hCdc21, P1-Cdc21, MGC33310 MCM4 minichromosome maintenance complex component 4; Involved in the control of DNA replication
4174 MCM5 4174 HGNC:6948 Hs.517582 201755_at
216237_s_at
minichromosome maintenance complex component 5 Minichromosome maintenance complex component 5 ENSG00000100297 ENSP00000216122 hsa+4174 MCM5 CDC46 MCM5 22q13.1-q13.2 Approved MCM5 minichromosome maintenance complex component 5
4175 MCM6 4175 HGNC:6949 Hs.444118 201930_at
238977_at
minichromosome maintenance complex component 6 Minichromosome maintenance complex component 6 ENSG00000076003 ENSP00000264156 hsa+4175 MCM6 MCM6 2q14-q21 Approved Mis5 MCM6 minichromosome maintenance complex component 6; May be involved in the control of a single round of DNA replication during S phase. Binds to chromatin during G1 and detach from it during S phase as if it licenses the chromatin to replicate
4176 MCM7 4176 HGNC:6950 Hs.438720 208795_s_at
210983_s_at
minichromosome maintenance complex component 7 Minichromosome maintenance complex component 7 ENSG00000166508 ENSP00000307288 hsa+4176 MCM7 MCM2 MCM7 7q21.3-q22.1 Approved CDC47 MCM7 minichromosome maintenance complex component 7; Acts as a factor that allows the DNA to undergo a single round of replication per cell cycle. Required for DNA replication and cell proliferation. Required for S-phase checkpoint activation upon UV-induced damage
84515 MCM8 84515 HGNC:16147 224320_s_at
233560_x_at
minichromosome maintenance complex component 8 ENSG00000125885 ENSP00000368174 MCM8 C20orf154 20p12.3 Approved MGC4816, MGC12866, MGC119522, MGC119523, dJ967N21.5, REC minichromosome maintenance complex component 8; May have a role in the control of cell proliferation. Appears to be involved in the activation of the prereplicative complex (pre-RC) during G(1) phase by recruiting CDC6 to the origin recognition complex (ORC). Binds chromatin throughout the cell cycle
79003 MIS12 79003 HGNC:24967 221559_s_at
MIS12, MIND kinetochore complex component, homolog (S. pombe) ENSG00000167842 ENSP00000370557 MIS12 17p13.3 Approved MGC2488, hMIS12, KNTC2AP, MTW1 MIS12, MIND kinetochore complex component, homolog (S. pombe); Part of the MIS12 complex which is required for normal chromosome alignment and segregation and for kinetochore formation during mitosis
79682 MLF1IP 79682 HGNC:21348 MLF1 interacting protein ENSG00000151725 ENSP00000281453 MLF1IP 4q35.1 Approved CENPU, CENP-U, KLIP1, CENP-50 MLF1 interacting protein; Component of the CENPA-NAC (nucleosome-associated) complex, a complex that plays a central role in assembly of kinetochore proteins, mitotic progression and chromosome segregation. The CENPA-NAC complex recruits the CENPA-CAD (nucleosome distal) complex and may be involved in incorporation of newly synthesized CENPA into centromeres. Plays an important role in the correct PLK1 localization to the mitotic kinetochores. A scaffold protein responsible for the initial recruitment and maintenance of the kinetochore PLK1 population until its degradation. Involved in [...]
10403 NDC80 10403 HGNC:16909 204162_at
NDC80 homolog, kinetochore complex component (S. cerevisiae) ENSG00000080986 ENSP00000261597 NDC80 KNTC2 18p11.31 Approved HEC, HEC1, hsNDC80, TID3 NDC80 homolog, kinetochore complex component (S. cerevisiae); Acts as a component of the essential kinetochore- associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity. Required for kinetochore integrity and the organization of stable microtubule binding sites in the outer plate of the kinetochore
54820 NDE1 54820 HGNC:17619 218414_s_at
222625_s_at
227249_at
227843_at
230219_at
nudE nuclear distribution gene E homolog 1 (A. nidulans) ENSG00000072864 ENSP00000345892 NDE1 16p13.11 Approved NUDE, FLJ20101 microRNA 484; Required for centrosome duplication. Essential for the development of the cerebral cortex. May regulate the production of neurons by controlling the orientation of the mitotic spindle during division of cortical neuronal progenitors of the proliferative ventricular zone of the brain. Orientation of the division plane perpendicular to the layers of the cortex gives rise to two proliferative neuronal progenitors whereas parallel orientation of the division plane yields one proliferative neuronal progenitor and a post-mitotic neuron. A premature shift towards a neuronal fate [...]
81565 NDEL1 81565 HGNC:17620 208093_s_at
nudE nuclear distribution gene E homolog (A. nidulans)-like 1 ENSG00000166579 ENSP00000333982 NDEL1 17p13.1 Approved NUDEL, MITAP1 nudE nuclear distribution gene E homolog (A. nidulans)-like 1; Facilitates the polymerization of neurofilaments from the individual subunits NEFH and NEFL (By similarity). Required for organization of the cellular microtubule array and microtubule anchoring at the centrosome. May regulate microtubule organization at least in part by targeting the microtubule severing protein KATNA1 to the centrosome. Also positively regulates the activity of the minus-end directed microtubule motor protein dynein. May enhance dynein-mediated microtubule sliding by targeting dynein to the microtubule pl [...]
25936 NSL1 25936 HGNC:24548 209483_s_at
209484_s_at
230592_at
235799_at
NSL1, MIND kinetochore complex component, homolog (S. cerevisiae) ENSG00000117697 ENSP00000355944 NSL1 C1orf48 1q41 Approved DC8, DKFZP566O1646, MIS14 NSL1, MIND kinetochore complex component, homolog (S. cerevisiae); Part of the MIS12 complex which is required for normal chromosome alignment and segregation and kinetochore formation during mitosis
10726 NUDC 10726 HGNC:8045 201173_x_at
210574_s_at
210575_at
nuclear distribution gene C homolog (A. nidulans) ENSG00000090273 ENSP00000319664 NUDC 1p35-p34 Approved NudC nuclear distribution gene C homolog (A. nidulans); Plays a role in neurogenesis and neuronal migration (By similarity). Necessary for correct formation of mitotic spindles and chromosome separation during mitosis. Necessary for cytokinesis and cell proliferation
83540 NUF2 83540 HGNC:14621 223381_at
NUF2, NDC80 kinetochore complex component, homolog (S. cerevisiae) ENSG00000143228 ENSP00000271452 NUF2 CDCA1 1q23.3 Approved NUF2R, CT106 NUF2, NDC80 kinetochore complex component, homolog (S. cerevisiae); Acts as a component of the essential kinetochore- associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity. Required for kinetochore integrity and the organization of stable microtubule binding sites in the outer plate of the kinetochore
57122 NUP107 57122 HGNC:29914 218768_at
nucleoporin 107kDa ENSG00000111581 ENSP00000229179 NUP107 12q14 Approved NUP84 nucleoporin 107kDa; Essential component of nuclear pore complex. Required for the assembly of peripheral proteins into the nuclear pore complex
55746 NUP133 55746 HGNC:18016 202184_s_at
233421_s_at
nucleoporin 133kDa ENSG00000069248 ENSP00000261396 NUP133 1q42.13 Approved FLJ10814 nucleoporin 133kDa; Involved in poly(A)+ RNA transport
23279 NUP160 23279 HGNC:18017 212709_at
214962_s_at
214963_at
nucleoporin 160kDa ENSG00000030066 ENSP00000367721 NUP160 11p11.12 Approved KIAA0197, FLJ22583 nucleoporin 160kDa; Involved in poly(A)+ RNA transport
79023 NUP37 79023 HGNC:29929 218622_at
nucleoporin 37kDa ENSP00000251074 NUP37 12q23 Approved MGC5585, FLJ22618 nucleoporin 37kDa; Component of the Nup107-160 subcomplex of the nuclear pore complex (NPC). The Nup107-160 subcomplex is required for the assembly of a functional NPC. The Nup107-160 subcomplex is also required for normal kinetochore microtubule attachment, mitotic progression and chromosome segregation
348995 NUP43 348995 HGNC:21182 219007_at
238474_at
nucleoporin 43kDa ENSG00000120253 ENSP00000342262 NUP43 6q25.1 Approved bA350J20.1, FLJ13287 nucleoporin 43kDa; Component of the Nup107-160 subcomplex of the nuclear pore complex (NPC). The Nup107-160 subcomplex is required for the assembly of a functional NPC. The Nup107-160 subcomplex is also required for normal kinetochore microtubule attachment, mitotic progression and chromosome segregation
79902 NUP85 79902 HGNC:8734 218014_at
nucleoporin 85kDa ENSP00000245544 NUP85 17q25 Approved NUP75, FLJ12549 nucleoporin 85kDa; Essential component of the nuclear pore complex (NPC) that seems to be required for NPC assembly and maintenance. As part of the NPC Nup107-160 subcomplex plays a role in RNA export and in tethering NUP98/Nup98 and NUP153 to the nucleus. The Nup107-160 complex seems to be required for spindle assembly during mitosis. NUP85 is required for membrane clustering of CCL2- activated CCR2. Seems to be involved in CCR2-mediated chemotaxis of monocytes and may link activated CCR2 to the phosphatidyl- inositol-3-kinase-Rac-lammellipodium protrusion cascade
4928 NUP98 4928 HGNC:8068 203194_s_at
203195_s_at
210793_s_at
nucleoporin 98kDa ENSG00000110713 ENSP00000316032 NUP98 11p15 Approved NUP96 nucleoporin 98kDa; Nup98 and Nup96 play a role in the bidirectional transport across the nucleoporin complex (NPC). The repeat domain in Nup98 has a direct role in the transport
4998 ORC1L 4998 HGNC:8487 Hs.17908 205085_at
origin recognition complex, subunit 1-like (yeast) Origin recognition complex, subunit 1-like (yeast) ENSG00000085840 ENSP00000360621 hsa+4998 ORC1L ORC1L 1p32 Approved HSORC1, ORC1, PARC1 ORC1L origin recognition complex, subunit 1-like (yeast); Component of the origin recognition complex (ORC) that binds origins of replication. Binds to the ARS consensus sequence (ACS) of origins of replication in an ATP-dependent manner
4999 ORC2L 4999 HGNC:8488 Hs.444870 204853_at
235423_at
origin recognition complex, subunit 2-like (yeast) Origin recognition complex, subunit 2-like (yeast) ENSG00000115942 ENSP00000234296 hsa+4999 ORC2L ORC2L 2q33 Approved ORC2L origin recognition complex, subunit 2-like (yeast); Component of the origin recognition complex (ORC) that binds origins of replication. Binds to the ARS consensus sequence (ACS) of origins of replication in an ATP-dependent manner
23595 ORC3L 23595 HGNC:8489 Hs.410228 210028_s_at
origin recognition complex, subunit 3-like (yeast) Origin recognition complex, subunit 3-like (yeast) ENSG00000135336 ENSP00000257789 hsa+23595 ORC3L ORC3L 6q Approved IMAGE50150, LATHEO ORC3L origin recognition complex, subunit 3-like (yeast); Component of the origin recognition complex (ORC) that binds origins of replication. Binds to the ARS consensus sequence (ACS) of origins of replication in an ATP-dependent manner
5000 ORC4L 5000 HGNC:8490 Hs.558364 203351_s_at
203352_at
origin recognition complex, subunit 4-like (yeast) Origin recognition complex, subunit 4-like (yeast) ENSG00000115947 ENSP00000264169 hsa+5000 ORC4L ORC4L 2q22-q23 Approved HsORC4, ORC4, Orc4p Orc4p origin recognition complex, subunit 4-like (yeast); Component of the origin recognition complex (ORC) that binds origins of replication. Binds to the ARS consensus sequence (ACS) of origins of replication in an ATP-dependent manner
5001 ORC5L 5001 HGNC:8491 Hs.432948 204957_at
211212_s_at
211213_at
origin recognition complex, subunit 5-like (yeast) Origin recognition complex, subunit 5-like (yeast) ENSG00000164815 ENSP00000297431 hsa+5001 ORC5L ORC5L 7q22.1 Approved Orc5p, ORC5, ORC5T Orc5p origin recognition complex, subunit 5-like (yeast); Component of the origin recognition complex (ORC) that binds origins of replication. Binds to the ARS consensus sequence (ACS) of origins of replication in an ATP-dependent manner
23594 ORC6L 23594 HGNC:17151 Hs.49760 219105_x_at
origin recognition complex, subunit 6 like (yeast) Origin recognition complex, subunit 6 like (yeast) ENSG00000091651 ENSP00000219097 hsa+23594 ORC6L ORC6L 16q12 Approved ORC6 ORC6 origin recognition complex, subunit 6 like (yeast); Component of the origin recognition complex (ORC) that binds origins of replication. Binds to the ARS consensus sequence (ACS) of origins of replication in an ATP-dependent manner
5048 PAFAH1B1 5048 HGNC:8574 Hs.77318 200813_s_at
200815_s_at
200816_s_at
211547_s_at
platelet-activating factor acetylhydrolase, isoform Ib, subunit 1 (45kDa) Platelet-activating factor acetylhydrolase, isoform Ib, alpha subunit 45kDa ENSG00000007168 ENSP00000380378 PAFAH1B1 MDCR, MDS PAFAH1B1 17p13.3 Approved LIS1, PAFAH PAFAH1B1 platelet-activating factor acetylhydrolase, isoform Ib, subunit 1 (45kDa); Required for proper activation of Rho GTPases and actin polymerization at the leading edge of locomoting cerebellar neurons and postmigratory hippocampal neurons in response to calcium influx triggered via NMDA receptors. Non-catalytic subunit of an acetylhydrolase complex which inactivates platelet- activating factor (PAF) by removing the acetyl group at the SN-2 position (By similarity). Positively regulates the activity of the minus-end directed microtubule motor protein dynein. May enhance dynein-mediated mi [...]
5347 PLK1 5347 HGNC:9077 Hs.592049 202240_at
polo-like kinase 1 (Drosophila) Polo-like kinase 1 (Drosophila) ENSG00000166851 ENSP00000300093 hsa+5347 PLK1 PLK PLK1 16p Approved PLK1 polo-like kinase 1 (Drosophila); Serine/threonine-protein kinase that performs several important functions throughout M phase of the cell cycle, including the regulation of centrosome maturation and spindle assembly, the removal of cohesins from chromosome arms, the inactivation of APC/C inhibitors, and the regulation of mitotic exit and cytokinesis
11243 PMF1 11243 HGNC:9112 202337_at
polyamine-modulated factor 1 ENSG00000160783 ENSP00000357260 PMF1 1q22 Approved polyamine-modulated factor 1; Part of the MIS12 complex which is required for normal chromosome alignment and segregation and kinetochore formation during mitosis. May act as a cotranscription partner of NFE2L2 involved in regulation of polyamine-induced transcription of SSAT
5422 POLA1 5422 HGNC:9173 Hs.567319 204835_at
polymerase (DNA directed), alpha 1, catalytic subunit Polymerase (DNA directed), alpha 1, catalytic subunit GO:0006303 ENSG00000101868 ENSP00000368349 POLA1 POLA POLA1 IMP Xp22.1-p21.3 Approved p180 POLA1 polymerase (DNA directed), alpha 1, catalytic subunit; Plays an essential role in the initiation of DNA replication. During the S phase of the cell cycle, the DNA polymerase alpha complex (composed of a catalytic subunit POLA1/p180, a regulatory subunit POLA2/p70 and two primase subunits PRIM1/p49 and PRIM2/p58) is recruited to DNA at the replicative forks via direct interactions with MCM10 and WDHD1. The primase subunit of the polymerase alpha complex initiates DNA synthesis by oligomerising short RNA primers on both leading and lagging strands. These primers are initially extended by [...]
23649 POLA2 23649 HGNC:30073 204441_s_at
244575_at
polymerase (DNA directed), alpha 2 (70kD subunit) ENSG00000014138 ENSP00000265465 POLA2 11q13 Approved FLJ21662 polymerase (DNA directed), alpha 2 (70kD subunit); May play an essential role at the early stage of chromosomal DNA replication by coupling the polymerase alpha/primase complex to the cellular replication machinery (By similarity)
5426 POLE 5426 HGNC:9177 Hs.524871 Hs.657680 216026_s_at
polymerase (DNA directed), epsilon Polymerase (DNA directed), epsilon GO:0006297 ENSG00000177084 ENSP00000322570 hsa+5426 POLE POLE EXP 12q24.3 Approved POLE1 POLE polymerase (DNA directed), epsilon; Participates in DNA repair and in chromosomal DNA replication
5427 POLE2 5427 HGNC:9178 Hs.162777 205909_at
polymerase (DNA directed), epsilon 2 (p59 subunit) Polymerase (DNA directed), epsilon 2 (p59 subunit) GO:0006297 ENSG00000100479 ENSP00000216367 hsa+5427 POLE2 POLE2 EXP 14q21-q22 Approved DPE2 DPE2 polymerase (DNA directed), epsilon 2 (p59 subunit); Participates in DNA repair and in chromosomal DNA replication
5501 PPP1CC 5501 HGNC:9283 200726_at
protein phosphatase 1, catalytic subunit, gamma isozyme ENSG00000186298 ENSP00000335084 PPP1CC 12q24.1-q24.2 Approved PP1gamma protein phosphatase 1, catalytic subunit, gamma isoform; Protein phosphatase 1 (PP1) is essential for cell division, and participates in the regulation of glycogen metabolism, muscle contractility and protein synthesis. Involved in regulation of ionic conductances and long-term synaptic plasticity. May play an important role in dephosphorylating substrates such as the postsynaptic density-associated Ca(2+)/calmodulin dependent protein kinase II
5515 PPP2CA 5515 HGNC:9299 Hs.483408 208652_at
235502_at
238719_at
protein phosphatase 2 (formerly 2A), catalytic subunit, alpha isoform Protein phosphatase 2 (formerly 2A), catalytic subunit, alpha isoform ENSG00000113575 ENSP00000418447 PPP2CA PPP2CA 5q31.1 Approved PPP2CA protein phosphatase 2 (formerly 2A), catalytic subunit, alpha isoform; PP2A can modulate the activity of phosphorylase B kinase casein kinase 2, mitogen-stimulated S6 kinase, and MAP-2 kinase. Can dephosphorylate SV40 large T antigen and p53. Dephosphorylates SV40 large T antigen, preferentially on serine residues 120, 123, 677, and perhaps 679. The C subunit was most active, followed by the AC form, which was more active than the ABC form, and activity of all three forms was strongly stimulated by manganese, and to a lesser extent by magnesium. Dephosphorylation by the AC form, but no [...]
5516 PPP2CB 5516 HGNC:9300 201374_x_at
201375_s_at
protein phosphatase 2, catalytic subunit, beta isozyme ENSG00000104695 ENSP00000221138 PPP2CB 8p12 Approved PP2Abeta protein phosphatase 2 (formerly 2A), catalytic subunit, beta isoform; PP2A can modulate the activity of phosphorylase B kinase casein kinase 2, mitogen-stimulated S6 kinase, and MAP-2 kinase. Can dephosphorylate SV40 large T antigen and p53. Dephosphorylates SV40 large T antigen, preferentially on serine residues 120, 123, 677, and perhaps 679. The C subunit was most active, followed by the AC form, which was more active than the ABC form, and activity of all three forms was strongly stimulated by manganese, and to a lesser extent by magnesium. Dephosphorylation by the AC form, but not [...]
5518 PPP2R1A 5518 HGNC:9302 200695_at
protein phosphatase 2, regulatory subunit A, alpha ENSG00000105568 ENSP00000324804 PPP2R1A 19q13 Approved PR65A, PP2A-Aalpha protein phosphatase 2 (formerly 2A), regulatory subunit A, alpha isoform; The PR65 subunit of protein phosphatase 2A serves as a scaffolding molecule to coordinate the assembly of the catalytic subunit and a variable regulatory B subunit
5519 PPP2R1B 5519 HGNC:9303 202883_s_at
202884_s_at
202885_s_at
202886_s_at
222351_at
protein phosphatase 2, regulatory subunit A, beta ENSG00000137713 ENSP00000311344 PPP2R1B 11q23.1 Approved PR65B, PP2A-Abeta protein phosphatase 2 (formerly 2A), regulatory subunit A, beta isoform; The PR65 subunit of protein phosphatase 2A serves as a scaffolding molecule to coordinate the assembly of the catalytic subunit and a variable regulatory B subunit
5525 PPP2R5A 5525 HGNC:9309 202186_x_at
202187_s_at
protein phosphatase 2, regulatory subunit B', alpha ENSG00000066027 ENSP00000261461 PPP2R5A 1q32.2-q32.3 Approved PR61A, B56A protein phosphatase 2, regulatory subunit B', alpha isoform; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment
5526 PPP2R5B 5526 HGNC:9310 204611_s_at
635_s_at
protein phosphatase 2, regulatory subunit B', beta ENSG00000068971 ENSP00000164133 PPP2R5B 11q12 Approved FLJ35411, B56B, PR61B protein phosphatase 2, regulatory subunit B', beta isoform; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment
5527 PPP2R5C 5527 HGNC:9311 1554364_at
1554365_a_at
1557718_at
201877_s_at
213305_s_at
214083_at
protein phosphatase 2, regulatory subunit B', gamma ENSG00000078304 ENSP00000333905 PPP2R5C 14q32.31 Approved B56G, PR61G protein phosphatase 2, regulatory subunit B', gamma isoform; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment
5528 PPP2R5D 5528 HGNC:9312 Hs.533308 202513_s_at
211159_s_at
protein phosphatase 2, regulatory subunit B Protein phosphatase 2, regulatory subunit B ENSG00000112640 ENSP00000417963 PPP2R5D PPP2R5D 6p21.1 Approved B56D B56D protein phosphatase 2, regulatory subunit B', delta isoform; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment
5557 PRIM1 5557 HGNC:9369 205053_at
primase, DNA, polypeptide 1 (49kDa) ENSP00000350491 PRIM1 12q13.3 Approved primase, DNA, polypeptide 1 (49kDa); DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments made during discontinuous DNA replication
5558 PRIM2 5558 HGNC:9370 1554884_at
1554885_a_at
205628_at
215708_s_at
215709_at
primase, DNA, polypeptide 2 (58kDa) ENSG00000146143 ENSP00000402620 PRIM2 PRIM2A 6p12-p11.1 Approved primase, DNA, polypeptide 2 (58kDa); DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments made during discontinuous DNA replication
5682 PSMA1 5682 HGNC:9530 Hs.102798 201676_x_at
210759_s_at
211746_x_at
proteasome (prosome, macropain) subunit, alpha type, 1 Proteasome (prosome, macropain) subunit, alpha type, 1 ENSG00000129084 ENSP00000315309 PSMA1 PSMA1 11p15.1 Approved HC2, NU, PROS30, MGC14542, MGC14575, MGC14751, MGC1667, MGC21459, MGC22853, MGC23915 PSMA1 proteasome (prosome, macropain) subunit, alpha type, 1; The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity (By similarity)
5683 PSMA2 5683 HGNC:9531 Hs.333786 201316_at
201317_s_at
53202_at
proteasome (prosome, macropain) subunit, alpha type, 2 Proteasome (prosome, macropain) subunit, alpha type, 2 ENSG00000106588 ENSP00000223321 PSMA2 PSMA2 7p13 Approved MU, HC3, PMSA2 PSMA2 proteasome (prosome, macropain) subunit, alpha type, 2; The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity. PSMA2 may have a potential regulatory effect on another component(s) of the proteasome complex through tyrosine phosphorylation
5684 PSMA3 5684 HGNC:9532 Hs.558799 201532_at
232648_at
237300_at
proteasome (prosome, macropain) subunit, alpha type, 3 Proteasome (prosome, macropain) subunit, alpha type, 3 ENSG00000100567 ENSP00000216455 PSMA3 PSMA3 14q23 Approved HC8 HC8 proteasome (prosome, macropain) subunit, alpha type, 3; The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity (By similarity)
5685 PSMA4 5685 HGNC:9533 Hs.251531 203396_at
proteasome (prosome, macropain) subunit, alpha type, 4 Proteasome (prosome, macropain) subunit, alpha type, 4 ENSG00000041357 ENSP00000044462 PSMA4 PSMA4 15q24.1 Approved HC9, HsT17706 PSMA4 proteasome (prosome, macropain) subunit, alpha type, 4; The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity (By similarity)
5686 PSMA5 5686 HGNC:9534 Hs.712557 201274_at
proteasome (prosome, macropain) subunit, alpha type, 5 Proteasome (prosome, macropain) subunit, alpha type, 5 ENSG00000143106 ENSP00000271308 PSMA5 PSMA5 1p13 Approved ZETA PSMA5 proteasome (prosome, macropain) subunit, alpha type, 5; The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity (By similarity)
5687 PSMA6 5687 HGNC:9535 Hs.446260 208805_at
proteasome (prosome, macropain) subunit, alpha type, 6 Proteasome (prosome, macropain) subunit, alpha type, 6 ENSG00000100902 ENSP00000261479 PSMA6 PSMA6 14q13 Approved IOTA, PROS27, p27K, MGC22756, MGC2333, MGC23846 IOTA proteasome (prosome, macropain) subunit, alpha type, 6; The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity
5688 PSMA7 5688 HGNC:9536 Hs.233952 201114_x_at
216088_s_at
proteasome (prosome, macropain) subunit, alpha type, 7 Proteasome (prosome, macropain) subunit, alpha type, 7 ENSG00000101182 ENSP00000359910 PSMA7 PSMA7 20q13.33 Approved XAPC7, C6, HSPC, RC6-1 PSMA7 proteasome (prosome, macropain) subunit, alpha type, 7; The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity (By similarity)
143471 PSMA8 143471 HGNC:22985 240091_at
proteasome (prosome, macropain) subunit, alpha type, 8 ENSP00000311121 PSMA8 18q11.2 Approved MGC26605, PSMA7L proteasome (prosome, macropain) subunit, alpha type, 8; The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity (By similarity). This may be a testis-specific subunit
5689 PSMB1 5689 HGNC:9537 Hs.352768 200876_s_at
214288_s_at
214289_at
proteasome (prosome, macropain) subunit, beta type, 1 Proteasome (prosome, macropain) subunit, beta type, 1 ENSG00000008018 ENSP00000262193 PSMB1 PSMB1 6q27 Approved PMSB1, HC5 PSMB1 proteasome (prosome, macropain) subunit, beta type, 1; The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity (By similarity)
5699 PSMB10 5699 HGNC:9538 Hs.9661 202659_at
proteasome (prosome, macropain) subunit, beta type, 10 Proteasome (prosome, macropain) subunit, beta type, 10 ENSG00000205220 ENSP00000351314 PSMB10 MECL1 PSMB10 16q22.1 Approved LMP10, MGC1665, beta2i PSMB10 proteasome (prosome, macropain) subunit, beta type, 10; The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity. This subunit is involved in antigen processing to generate class I binding peptides
122706 PSMB11 122706 HGNC:31963 proteasome (prosome, macropain) subunit, beta type, 11 ENSP00000386212 PSMB11 14q11.2 Approved beta5t proteasome (prosome, macropain) subunit, beta type, 11; The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity. PSMB11 plays a pivotal role in development of CD8- positive T cells (By similarity)
5690 PSMB2 5690 HGNC:9539 Hs.471441 200039_s_at
201404_x_at
231323_at
proteasome (prosome, macropain) subunit, beta type, 2 Proteasome (prosome, macropain) subunit, beta type, 2 ENSG00000126067 ENSP00000362334 PSMB2 PSMB2 1p34.2 Approved HC7-I PSMB2 proteasome (prosome, macropain) subunit, beta type, 2; The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity. This subunit has a chymotrypsin-like activity
5691 PSMB3 5691 HGNC:9540 Hs.82793 201400_at
proteasome (prosome, macropain) subunit, beta type, 3 Proteasome (prosome, macropain) subunit, beta type, 3 ENSG00000108294 ENSP00000225426 PSMB3 PSMB3 17q12 Approved HC10-II, MGC4147 PSMB3 proteasome (prosome, macropain) subunit, beta type, 3; The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity
5692 PSMB4 5692 HGNC:9541 Hs.89545 202243_s_at
202244_at
proteasome (prosome, macropain) subunit, beta type, 4 Proteasome (prosome, macropain) subunit, beta type, 4 ENSG00000159377 ENSP00000290541 PSMB4 PSMB4 1q21 Approved HN3, PROS26 PSMB4 proteasome (prosome, macropain) subunit, beta type, 4; The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity
5693 PSMB5 5693 HGNC:9542 Hs.422990 208799_at
proteasome (prosome, macropain) subunit, beta type, 5 Proteasome (prosome, macropain) subunit, beta type, 5 ENSG00000100804 ENSP00000355325 PSMB5 PSMB5 14q11.2 Approved X, MB1 X proteasome (prosome, macropain) subunit, beta type, 5; The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity. May catalyze basal processing of intracellular antigens
5694 PSMB6 5694 HGNC:9543 Hs.77060 208827_at
proteasome (prosome, macropain) subunit, beta type, 6 Proteasome (prosome, macropain) subunit, beta type, 6 ENSG00000142507 ENSP00000270586 PSMB6 PSMB6 17p13 Approved Y, DELTA PSMB6 proteasome (prosome, macropain) subunit, beta type, 6; The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity. May catalyze basal processing of intracellular antigens
5695 PSMB7 5695 HGNC:9544 Hs.213470 200786_at
244801_at
proteasome (prosome, macropain) subunit, beta type, 7 Proteasome (prosome, macropain) subunit, beta type, 7 ENSG00000136930 ENSP00000259457 PSMB7 PSMB7 9q34.11-q34.12 Approved Z PSMB7 proteasome (prosome, macropain) subunit, beta type, 7; The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity (By similarity)
5696 PSMB8 5696 HGNC:9545 Hs.180062 209040_s_at
proteasome (prosome, macropain) subunit, beta type, 8 (large multifunctional peptidase 7) Proteasome (prosome, macropain) subunit, beta type, 8 (large multifunctional peptidase 7) ENSG00000206234 ENSP00000406797 PSMB8 LMP7 PSMB8 6p21.3 Approved RING10, D6S216E, PSMB5i, beta5i ENSG00000206234 proteasome (prosome, macropain) subunit, beta type, 8 (large multifunctional peptidase 7)
5698 PSMB9 5698 HGNC:9546 Hs.654585 204279_at
proteasome (prosome, macropain) subunit, beta type, 9 (large multifunctional peptidase 2) Proteasome (prosome, macropain) subunit, beta type, 9 (large multifunctional peptidase 2) ENSG00000206296 ENSP00000396813 PSMB9 LMP2 PSMB9 6p21.3 Approved RING12, beta1i, PSMB6i ENSG00000206296 proteasome (prosome, macropain) subunit, beta type, 9 (large multifunctional peptidase 2); The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity. This subunit is involved in antigen processing to generate class I binding peptides
5700 PSMC1 5700 HGNC:9547 Hs.356654 204219_s_at
proteasome (prosome, macropain) 26S subunit, ATPase, 1 Proteasome (prosome, macropain) 26S subunit, ATPase, 1 ENSG00000100764 ENSP00000261303 PSMC1 PSMC1 14q32.11 Approved S4, p56 S4 proteasome (prosome, macropain) 26S subunit, ATPase, 1; The 26S protease is involved in the ATP-dependent degradation of ubiquitinated proteins. The regulatory (or ATPase) complex confers ATP dependency and substrate specificity to the 26S complex
5701 PSMC2 5701 HGNC:9548 Hs.437366 201067_at
201068_s_at
238020_at
proteasome (prosome, macropain) 26S subunit, ATPase, 2 Proteasome (prosome, macropain) 26S subunit, ATPase, 2 ENSG00000161057 ENSP00000292644 PSMC2 PSMC2 7q22.1-q22.3 Approved MSS1, S7, Nbla10058 S7 proteasome (prosome, macropain) 26S subunit, ATPase, 2; The 26S protease is involved in the ATP-dependent degradation of ubiquitinated proteins. The regulatory (or ATPase) complex confers ATP dependency and substrate specificity to the 26S complex. In case of HIV-1 infection, positive modulator of Tat-mediated transactivation
5702 PSMC3 5702 HGNC:9549 Hs.250758 201267_s_at
proteasome (prosome, macropain) 26S subunit, ATPase, 3 Proteasome (prosome, macropain) 26S subunit, ATPase, 3 ENSG00000165916 ENSP00000298852 PSMC3 PSMC3 11p11.2 Approved TBP1 PSMC3 proteasome (prosome, macropain) 26S subunit, ATPase, 3; The 26S protease is involved in the ATP-dependent degradation of ubiquitinated proteins. The regulatory (or ATPase) complex confers ATP dependency and substrate specificity to the 26S complex (By similarity). In case of HIV-1 infection, suppresses Tat-mediated transactivation
5704 PSMC4 5704 HGNC:9551 Hs.211594 201252_at
Proteasome (prosome, macropain) 26S subunit, ATPase, 4 ENSG00000013275 ENSP00000157812 PSMC4 MIP224 PSMC4 19q13.11-q13.13 Approved TBP7, S6, MGC8570, MGC13687, MGC23214 S6 proteasome (prosome, macropain) 26S subunit, ATPase, 4; The 26S protease is involved in the ATP-dependent degradation of ubiquitinated proteins. The regulatory (or ATPase) complex confers ATP dependency and substrate specificity to the 26S complex
5705 PSMC5 5705 HGNC:9552 Hs.79387 209503_s_at
proteasome (prosome, macropain) 26S subunit, ATPase, 5 Proteasome (prosome, macropain) 26S subunit, ATPase, 5 ENSG00000087191 ENSP00000310572 PSMC5 PSMC5 17q23.3 Approved SUG1, p45/SUG, TBP10, p45, S8, TRIP1 PSMC5 proteasome (prosome, macropain) 26S subunit, ATPase, 5; The 26S protease is involved in the ATP-dependent degradation of ubiquitinated proteins. The regulatory (or ATPase) complex confers ATP dependency and substrate specificity to the 26S complex
5706 PSMC6 5706 HGNC:9553 Hs.156171 201699_at
proteasome (prosome, macropain) 26S subunit, ATPase, 6 Proteasome (prosome, macropain) 26S subunit, ATPase, 6 ENSG00000100519 ENSP00000401802 PSMC6 PSMC6 14q22.1 Approved p42 p42 proteasome (prosome, macropain) 26S subunit, ATPase, 6; The 26S protease is involved in the ATP-dependent degradation of ubiquitinated proteins. The regulatory (or ATPase) complex confers ATP dependency and substrate specificity to the 26S complex
5707 PSMD1 5707 HGNC:9554 Hs.3887 201198_s_at
201199_s_at
proteasome (prosome, macropain) 26S subunit, non-ATPase, 1 Proteasome (prosome, macropain) 26S subunit, non-ATPase, 1 ENSG00000173692 ENSP00000309474 PSMD1 PSMD1 2q37.1 Approved S1, P112, Rpn2 S1 proteasome (prosome, macropain) 26S subunit, non-ATPase, 1; Acts as a regulatory subunit of the 26 proteasome which is involved in the ATP-dependent degradation of ubiquitinated proteins
5716 PSMD10 5716 HGNC:9555 Hs.522752 1554577_a_at
219485_s_at
proteasome (prosome, macropain) 26S subunit, non-ATPase, 10 Proteasome (prosome, macropain) 26S subunit, non-ATPase, 10 ENSG00000101843 ENSP00000217958 PSMD10 PSMD10 Xq22.3 Approved p28 PSMD10 proteasome (prosome, macropain) 26S subunit, non-ATPase, 10; Acts as a regulatory subunit of the 26S proteasome which is involved in the ATP-dependent degradation of ubiquitinated proteins
5717 PSMD11 5717 HGNC:9556 Hs.655396 208776_at
208777_s_at
proteasome (prosome, macropain) 26S subunit, non-ATPase, 11 Proteasome (prosome, macropain) 26S subunit, non-ATPase, 11 ENSG00000108671 ENSP00000261712 PSMD11 PSMD11 17q12 Approved S9, p44.5, MGC3844, Rpn6 PSMD11 proteasome (prosome, macropain) 26S subunit, non-ATPase, 11; Acts as a regulatory subunit of the 26S proteasome which is involved in the ATP-dependent degradation of ubiquitinated proteins
5718 PSMD12 5718 HGNC:9557 Hs.646575 202352_s_at
202353_s_at
proteasome (prosome, macropain) 26S subunit, non-ATPase, 12 Proteasome (prosome, macropain) 26S subunit, non-ATPase, 12 ENSG00000197170 ENSP00000348442 PSMD12 PSMD12 17q24.3 Approved p55, Rpn5 PSMD12 proteasome (prosome, macropain) 26S subunit, non-ATPase, 12; Acts as a regulatory subunit of the 26S proteasome which is involved in the ATP-dependent degradation of ubiquitinated proteins
5719 PSMD13 5719 HGNC:9558 Hs.134688 201232_s_at
201233_at
proteasome (prosome, macropain) 26S subunit, non-ATPase, 13 Proteasome (prosome, macropain) 26S subunit, non-ATPase, 13 ENSG00000185627 ENSP00000396937 PSMD13 PSMD13 11p15.5 Approved p40.5, Rpn9 PSMD13 proteasome (prosome, macropain) 26S subunit, non-ATPase, 13; Acts as a regulatory subunit of the 26S proteasome which is involved in the ATP-dependent degradation of ubiquitinated proteins
10213 PSMD14 10213 HGNC:16889 Hs.567410 212296_at
proteasome (prosome, macropain) 26S subunit, non-ATPase, 14 Proteasome (prosome, macropain) 26S subunit, non-ATPase, 14 ENSG00000115233 ENSP00000386541 PSMD14 PSMD14 2q14.3 Approved POH1, pad1, Rpn11 POH1 proteasome (prosome, macropain) 26S subunit, non-ATPase, 14; Metalloprotease component of the 26S proteasome that specifically cleaves 'Lys-63'-linked polyubiquitin chains. The 26S proteasome is involved in the ATP-dependent degradation of ubiquitinated proteins. The function of the 'Lys-63'-specific deubiquitination of the proteasome is unclear
5708 PSMD2 5708 HGNC:9559 Hs.518464 200830_at
proteasome (prosome, macropain) 26S subunit, non-ATPase, 2 Proteasome (prosome, macropain) 26S subunit, non-ATPase, 2 ENSG00000175166 ENSP00000310129 PSMD2 PSMD2 3q27.3 Approved S2, P97, TRAP2, MGC14274, Rpn1 PSMD2 proteasome (prosome, macropain) 26S subunit, non-ATPase, 2; Acts as a regulatory subunit of the 26 proteasome which is involved in the ATP-dependent degradation of ubiquitinated proteins
5709 PSMD3 5709 HGNC:9560 Hs.12970 201388_at
proteasome (prosome, macropain) 26S subunit, non-ATPase, 3 Proteasome (prosome, macropain) 26S subunit, non-ATPase, 3 ENSG00000108344 ENSP00000264639 PSMD3 PSMD3 17q21.2 Approved S3, P58, Rpn3 PSMD3 proteasome (prosome, macropain) 26S subunit, non-ATPase, 3; Acts as a regulatory subunit of the 26 proteasome which is involved in the ATP-dependent degradation of ubiquitinated proteins
5710 PSMD4 5710 HGNC:9561 Hs.505059 200882_s_at
210459_at
210460_s_at
211609_x_at
proteasome (prosome, macropain) 26S subunit, non-ATPase, 4 Proteasome (prosome, macropain) 26S subunit, non-ATPase, 4 ENSG00000159352 ENSP00000357879 PSMD4 PSMD4 1q21.2 Approved S5A, AF-1, AF, Rpn10 PSMD4 proteasome (prosome, macropain) 26S subunit, non-ATPase, 4; Binds and presumably selects ubiquitin-conjugates for destruction. Displays selectivity for longer polyubiquitin chains. Modulates intestinal fluid secretion
5711 PSMD5 5711 HGNC:9563 Hs.193725 203447_at
215546_at
proteasome (prosome, macropain) 26S subunit, non-ATPase, 5 Proteasome (prosome, macropain) 26S subunit, non-ATPase, 5 ENSG00000095261 ENSP00000210313 PSMD5 PSMD5 9q34.11 Approved S5B, KIAA0072 PSMD5 proteasome (prosome, macropain) 26S subunit, non-ATPase, 5; Belongs to the 26S multisubunit protease, which is required for ubiquitin-dependent proteolysis. Does not bind ubiquitin polymers
9861 PSMD6 9861 HGNC:9564 Hs.152536 1555884_at
202753_at
232284_at
proteasome (prosome, macropain) 26S subunit, non-ATPase, 6 Proteasome (prosome, macropain) 26S subunit, non-ATPase, 6 ENSG00000163636 ENSP00000295901 PSMD6 PSMD6 3p14.1 Approved S10, p44S10, KIAA0107, Rpn7 PSMD6 proteasome (prosome, macropain) 26S subunit, non-ATPase, 6; Acts as a regulatory subunit of the 26S proteasome which is involved in the ATP-dependent degradation of ubiquitinated proteins
5713 PSMD7 5713 HGNC:9565 Hs.440604 201705_at
238738_at
244515_at
proteasome (prosome, macropain) 26S subunit, non-ATPase, 7 Proteasome (prosome, macropain) 26S subunit, non-ATPase, 7 ENSG00000103035 ENSP00000219313 PSMD7 PSMD7 16q22.3 Approved S12, P40, MOV34, Rpn8 PSMD7 proteasome (prosome, macropain) 26S subunit, non-ATPase, 7; Acts as a regulatory subunit of the 26S proteasome which is involved in the ATP-dependent degradation of ubiquitinated proteins
5714 PSMD8 5714 HGNC:9566 Hs.78466 200820_at
proteasome (prosome, macropain) 26S subunit, non-ATPase, 8 Proteasome (prosome, macropain) 26S subunit, non-ATPase, 8 ENSG00000099341 ENSP00000215071 PSMD8 PSMD8 19q13.2 Approved S14, Nin1p, p31, HIP6, HYPF, Rpn12 PSMD8 proteasome (prosome, macropain) 26S subunit, non-ATPase, 8; Acts as a regulatory subunit of the 26S proteasome which is involved in the ATP-dependent degradation of ubiquitinated proteins. Necessary for activation of the CDC28 kinase
5715 PSMD9 5715 HGNC:9567 Hs.131151 207805_s_at
209334_s_at
proteasome (prosome, macropain) 26S subunit, non-ATPase, 9 Proteasome (prosome, macropain) 26S subunit, non-ATPase, 9 ENSG00000110801 ENSP00000261817 PSMD9 PSMD9 12q24.31-q24.32 Approved p27, Rpn4 PSMD9 proteasome (prosome, macropain) 26S subunit, non-ATPase, 9; Acts as a regulatory subunit of the 26S proteasome which is involved in the ATP-dependent degradation of ubiquitinated proteins
5720 PSME1 5720 HGNC:9568 Hs.75348 200814_at
proteasome (prosome, macropain) activator subunit 1 (PA28 alpha) Proteasome (prosome, macropain) activator subunit 1 (PA28 alpha) ENSG00000092010 ENSP00000372155 PSME1 PSME1 14q11.2 Approved IFI5111, PA28alpha PSME1 proteasome (prosome, macropain) activator subunit 1 (PA28 alpha); Implicated in immunoproteasome assembly and required for efficient antigen processing. The PA28 activator complex enhances the generation of class I binding peptides by altering the cleavage pattern of the proteasome
5721 PSME2 5721 HGNC:9569 Hs.434081 Hs.512410 201762_s_at
proteasome (prosome, macropain) activator subunit 2 (PA28 beta) Proteasome (prosome, macropain) activator subunit 2 (PA28 beta) ENSG00000100911 ENSP00000216802 PSME2 PSME2 14q11.2 Approved PA28beta PSME2 proteasome (prosome, macropain) activator subunit 2 (PA28 beta); Implicated in immunoproteasome assembly and required for efficient antigen processing. The PA28 activator complex enhances the generation of class I binding peptides by altering the cleavage pattern of the proteasome
10197 PSME3 10197 HGNC:9570 Hs.152978 200987_x_at
200988_s_at
209852_x_at
209853_s_at
proteasome (prosome, macropain) activator subunit 3 (PA28 gamma; Ki) Proteasome (prosome, macropain) activator subunit 3 (PA28 gamma; Ki) ENSG00000131467 ENSP00000293362 PSME3 PSME3 17q12-q21 Approved Ki, PA28-gamma, REG-GAMMA, PA28G PSME3 proteasome (prosome, macropain) activator subunit 3 (PA28 gamma; Ki); Subunit of the 11S REG-gamma (also called PA28-gamma) proteasome regulator, a donut-shaped homoheptamer which associates with the proteasome. 11S REG-gamma activates the trypsin-like catalytic subunit of the proteasome but inhibits the chymotrypsin- like and postglutamyl-preferring (PGPH) subunits. Facilitates the MDM2-TP53/p53 interaction which promotes ubiquitination- and MDM2- dependent proteasomal degradation of TP53/p53, limiting its accumulation and resulting in inhibited apoptosis after DNA damage. May also be [...]
23198 PSME4 23198 HGNC:20635 212219_at
212220_at
212222_at
237180_at
proteasome (prosome, macropain) activator subunit 4 ENSG00000068878 ENSP00000384211 PSME4 2p16.1 Approved PA200, KIAA0077 proteasome (prosome, macropain) activator subunit 4; Activates proteasomal cleavage of peptides in an energy- independent manner. May be involved in spermatogenesis. May be involved in DNA repair
9491 PSMF1 9491 HGNC:9571 Hs.471917 201052_s_at
201053_s_at
235993_at
236012_at
proteasome (prosome, macropain) inhibitor subunit 1 (PI31) Proteasome (prosome, macropain) inhibitor subunit 1 (PI31) ENSG00000125818 ENSP00000327704 PSMF1 PSMF1 20p13 Approved PI31 PSMF1 proteasome (prosome, macropain) inhibitor subunit 1 (PI31); Plays an important role in control of proteasome function. Inhibits the hydrolysis of protein and peptide substrates by the 20S proteasome. Also inhibits the activation of the proteasome by the proteasome regulatory proteins PA700 and PA28
5885 RAD21 5885 HGNC:9811 200607_s_at
200608_s_at
RAD21 homolog (S. pombe) ENSG00000164754 ENSP00000297338 RAD21 8q24.11 Approved KIAA0078, hHR21, SCC1 RAD21 homolog (S. pombe); Cleavable component of the cohesin complex, involved in chromosome cohesion during cell cycle, in DNA repair, and in apoptosis. The cohesin complex is required for the cohesion of sister chromatids after DNA replication. The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped. At metaphase-anaphase transition, this protein is cleaved by separase/ESPL1 and dissociates from chromatin, allowing sister chromatids to segregate. The cohesin complex may also play a role in spindle pole assembly during mitosis. Als [...]
5903 RANBP2 5903 HGNC:9848 201711_x_at
201712_s_at
201713_s_at
226922_at
242712_x_at
RAN binding protein 2 ENSG00000153201 ENSP00000283195 RANBP2 2q13 Approved NUP358 RAN binding protein 2; E3 SUMO-protein ligase which facilitates SUMO1 and SUMO2 conjugation by UBE2I. Involved in transport factor (Ran-GTP, karyopherin)-mediated protein import via the F-G repeat-containing domain which acts as a docking site for substrates. Could also have isomerase or chaperone activity and may bind RNA or DNA. Component of the nuclear export pathway. Specific docking site for the nuclear export factor exportin-1
5905 RANGAP1 5905 HGNC:9854 1553535_a_at
212125_at
212127_at
Ran GTPase activating protein 1 ENSG00000100401 ENSP00000348577 RANGAP1 SD 22q13 Approved Fug1, KIAA1835 Ran GTPase activating protein 1; GTPase activator for the nuclear Ras-related regulatory protein Ran, converting it to the putatively inactive GDP-bound state
55920 RCC2 55920 HGNC:30297 224578_at
regulator of chromosome condensation 2 ENSG00000179051 ENSP00000364582 RCC2 1p36.13 Approved TD-60 regulator of chromosome condensation 2; Required for completion of mitosis and cytokinesis. May function as a guanine nucleotide exchange factor for the small GTPase RAC1
9985 REC8 9985 HGNC:16879 218599_at
229536_at
REC8 homolog (yeast) ENSP00000308699 REC8 REC8L1 14q11.2-q12 Approved Rec8p REC8 homolog (yeast); Required during meiosis for separation of sister chromatids and homologous chromosomes. Proteolytic cleavage of REC8 on chromosome arms by separin during anaphase I allows for homologous chromosome separation in meiosis I and cleavage of REC8 on centromeres during anaphase II allows for sister chromatid separation in meiosis II (By similarity)
6117 RPA1 6117 HGNC:10289 Hs.461925 201528_at
201529_s_at
236675_at
replication protein A1, 70kDa Replication protein A1, 70kDa GO:0000718 GO:0006297 ENSG00000132383 ENSP00000254719 hsa+6117 RPA1 RPA1 EXP 17p13.3 Approved REPA1, RPA70, HSSB, RF-A, RP-A MST075 replication protein A1, 70kDa; Plays an essential role in several cellular processes in DNA metabolism including replication, recombination and DNA repair. Binds and subsequently stabilizes single-stranded DNA intermediates and thus prevents complementary DNA from reannealing
6118 RPA2 6118 HGNC:10290 Hs.79411 201756_at
replication protein A2, 32kDa Replication protein A2, 32kDa GO:0000718 GO:0006297 ENSG00000117748 ENSP00000363021 hsa+6118 RPA2 RPA2 EXP 1p35 Approved RPA2 replication protein A2, 32kDa; Required for DNA recombination, repair and replication. The activity of RP-A is mediated by single-stranded DNA binding and protein interactions
6119 RPA3 6119 HGNC:10291 Hs.487540 209507_at
replication protein A3, 14kDa Replication protein A3, 14kDa GO:0000718 GO:0006297 ENSG00000106399 ENSP00000223129 hsa+6119 RPA3 RPA3 EXP 7 Approved REPA3 RPA3 replication protein A3, 14kDa; Required for DNA recombination, repair and replication. The activity of RP-A is mediated by single-stranded DNA binding and protein interactions
29935 RPA4 29935 HGNC:30305 Hs.659349 221143_at
replication protein A4, 34kDa Replication protein A4, 34kDa ENSG00000204086 ENSP00000362131 hsa+29935 RPA4 RPA4 Xq21 Approved HSU24186 RPA4 replication protein A4, 34kDa; Absolutely required for simian virus 40 DNA replication in vitro. It participates in a very early step in initiation. RP-A is a single-stranded DNA-binding protein (By similarity)
6232 RPS27 6232 HGNC:10416 200741_s_at
236621_at
ribosomal protein S27 ENSG00000177954 ENSP00000357555 RPS27 1q21 Approved MPS-1, MPS1, S27 ribosomal protein S27
6233 RPS27A 6233 HGNC:10417 Hs.311640 Hs.546292 200017_at
242214_at
244624_at
ribosomal protein S27a Ribosomal protein S27a ENSG00000143947 ENSP00000272317 RPS27A RPS27A 2p16 Approved UBCEP80, Uba80 UBB ribosomal protein S27a
6396 SEC13 6396 HGNC:10697 207707_s_at
SEC13 homolog (S. cerevisiae) ENSG00000157020 ENSP00000312122 SEC13 D3S1231E, SEC13L1 3p25-p24 Approved SEC13R, npp-20 SEC13 homolog (S. cerevisiae); May be involved in protein transport (By similarity)
81929 SEH1L 81929 HGNC:30379 221931_s_at
223225_s_at
SEH1-like (S. cerevisiae) ENSP00000382779 SEH1L 18p11.21 Approved SEH1A, SEH1B, Seh1, SEC13L SEH1-like (S. cerevisiae); Component of the Nup107-160 subcomplex of the nuclear pore complex (NPC). The Nup107-160 subcomplex is required for the assembly of a functional NPC. The Nup107-160 subcomplex is also required for normal kinetochore microtubule attachment, mitotic progression and chromosome segregation. This subunit plays a role in recruitment of the Nup107-160 subcomplex to the kinetochore
151648 SGOL1 151648 HGNC:25088 1553690_at
231938_at
shugoshin-like 1 (S. pombe) ENSG00000129810 ENSP00000263753 SGOL1 3p24.3 Approved NY-BR-85 shugoshin-like 1 (S. pombe); Plays a central role in chromosome cohesion during mitosis by preventing premature dissociation of cohesin complex from centromeres after prophase, when most of cohesin complex dissociates from chromosomes arms. May act by preventing phosphorylation of the STAG2 subunit of cohesin complex at the centromere, ensuring cohesin persistence at centromere until cohesin cleavage by ESPL1/separase at anaphase
151246 SGOL2 151246 HGNC:30812 230165_at
235425_at
shugoshin-like 2 (S. pombe) ENSG00000163535 ENSP00000350447 SGOL2 2q33.2 Approved TRIPIN, FLJ25211 shugoshin-like 2 (S. pombe); During meiosis, protects centromeric cohesion complexes until metaphase II/anaphase II transition, preventing premature release of meiosis-specific REC8 cohesin complexes from anaphase I centromeres. Is thus essential for an accurate gametogenesis (By similarity). May act by targeting PPP2CA to centromeres, thus leading to cohesin dephosphorylation
220134 SKA1 220134 HGNC:28109 217640_x_at
spindle and kinetochore associated complex subunit 1 ENSG00000154839 ENSP00000285116 SKA1 C18orf24 18q21.1 Approved MGC10200 spindle and kinetochore associated complex subunit 1; Component of the SKA1 complex, a microtubule-binding subcomplex of the outer kinetochore that is essential for proper chromosome segregation. Required for timely anaphase onset during mitosis, when chromosomes undergo bipolar attachment on spindle microtubules leading to silencing of the spindle checkpoint. The SKA1 complex is a direct component of the kinetochore-microtubule interface and directly associates with microtubules as oligomeric assemblies. The complex facilitates the processive movement of microspheres along a microtubu [...]
348235 SKA2 348235 HGNC:28006 225684_at
225686_at
spindle and kinetochore associated complex subunit 2 ENSG00000182628 ENSP00000333433 SKA2 FAM33A 17q23.2 Approved FLJ12758 spindle and kinetochore associated complex subunit 2; Component of the SKA1 complex, a microtubule-binding subcomplex of the outer kinetochore that is essential for proper chromosome segregation. Required for timely anaphase onset during mitosis, when chromosomes undergo bipolar attachment on spindle microtubules leading to silencing of the spindle checkpoint. The SKA1 complex is a direct component of the kinetochore-microtubule interface and directly associates with microtubules as oligomeric assemblies. The complex facilitates the processive movement of microspheres along a microtubu [...]
8243 SMC1A 8243 HGNC:11111 Hs.211602 1555677_s_at
201589_at
217555_at
239688_at
structural maintenance of chromosomes 1A Structural maintenance of chromosomes 1A ENSG00000072501 ENSP00000323421 hsa+8243 SMC1A SMC1L1 SMC1A Xp11.22-p11.21 Approved DXS423E, KIAA0178, SB1.8, Smcb SMC1A structural maintenance of chromosomes 1A; Involved in chromosome cohesion during cell cycle and in DNA repair. Central component of cohesin complex. The cohesin complex is required for the cohesion of sister chromatids after DNA replication. The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate. The cohesin complex may also play a role in spindle pole assembly during mitosis. Involved in DNA repair via its interaction with [...]
9126 SMC3 9126 HGNC:2468 Hs.24485 1556925_at
209257_s_at
209258_s_at
209259_s_at
structural maintenance of chromosomes 3 Structural maintenance of chromosomes 3 ENSG00000108055 ENSP00000354720 SMC3 CSPG6 SMC3 10q25 Approved HCAP, BAM, SMC3L1, bamacan SMC3 structural maintenance of chromosomes 3; Involved in chromosome cohesion during cell cycle and in DNA repair. Central component of cohesin complex. The cohesin complex is required for the cohesion of sister chromatids after DNA replication. The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate. The cohesin complex may also play a role in spindle pole assembly during mitosis and in chromosome movement
147841 SPC24 147841 HGNC:26913 235572_at
SPC24, NDC80 kinetochore complex component, homolog (S. cerevisiae) ENSP00000397131 SPC24 SPBC24 19p13.2 Approved FLJ90806 SPC24, NDC80 kinetochore complex component, homolog (S. cerevisiae); Acts as a component of the essential kinetochore- associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity. Required for kinetochore integrity and the organization of stable microtubule binding sites in the outer plate of the kinetochore
57405 SPC25 57405 HGNC:24031 209891_at
SPC25, NDC80 kinetochore complex component, homolog (S. cerevisiae) ENSG00000152253 ENSP00000282074 SPC25 SPBC25 2q31.1 Approved MGC22228, AD024 SPC25, NDC80 kinetochore complex component, homolog (S. cerevisiae); Acts as a component of the essential kinetochore- associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity. Required for kinetochore integrity and the organization of stable microtubule binding sites in the outer plate of the kinetochore
10274 STAG1 10274 HGNC:11354 202293_at
202294_at
232588_at
stromal antigen 1 ENSG00000118007 ENSP00000372689 STAG1 3q22.2-q22.3 Approved SA-1, SCC3A stromal antigen 1; Component of cohesin complex, a complex required for the cohesion of sister chromatids after DNA replication. The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate. The cohesin complex may also play a role in spindle pole assembly during mitosis
10735 STAG2 10735 HGNC:11355 207983_s_at
209022_at
209023_s_at
stromal antigen 2 ENSG00000101972 ENSP00000218089 STAG2 Xq25 Approved SA-2, SCC3B stromal antigen 2; Component of cohesin complex, a complex required for the cohesion of sister chromatids after DNA replication. The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate. The cohesin complex may also play a role in spindle pole assembly during mitosis
57551 TAOK1 57551 HGNC:29259 216310_at
227454_at
TAO kinase 1 ENSP00000261716 TAOK1 17q11.2 Approved KIAA1361, MARKK, PSK2, MAP3K16, FLJ14314, TAO1 TAO kinase 1; Phosphorylates MKK3 (By similarity). Activates the p38 MAP kinase pathway through the specific activation of the upstream MKK3 kinase
7311 UBA52 7311 HGNC:12458 221700_s_at
ubiquitin A-52 residue ribosomal protein fusion product 1 ENSG00000221983 ENSP00000388107 UBA52 19p13.1-p12 Approved RPL40, CEP52, HUBCEP52, MGC57125, MGC126879, MGC126881, L40 ubiquitin A-52 residue ribosomal protein fusion product 1; Protein modifier which can be covalently attached to target lysines either as a monomer or as a lysine-linked polymer. Attachment to proteins as a Lys-48-linked polymer usually leads to their degradation by proteasome. Attachment to proteins as a monomer or as an alternatively linked polymer does not lead to proteasomal degradation and may be required for numerous functions, including maintenance of chromatin structure, regulation of gene expression, stress response, ribosome biogenesis and DNA repair
7314 UBB 7314 HGNC:12463 Hs.356190 Hs.714712 200633_at
217144_at
ubiquitin B Similar to Os05g0242100 ENSG00000170315 ENSP00000304697 UBB UBB 17p12-p11.2 Approved MGC8385, FLJ25987 ENSG00000170315 ubiquitin B
7316 UBC 7316 HGNC:12468 Hs.520348 208980_s_at
211296_x_at
ubiquitin C Ubiquitin C ENSG00000150991 ENSP00000344818 UBC UBC 12q24.3 Approved UBC ubiquitin C
7514 XPO1 7514 HGNC:12825 Hs.370770 208775_at
235927_at
244012_x_at
exportin 1 (CRM1 homolog, yeast) Exportin 1 (CRM1 homolog, yeast) ENSG00000082898 ENSP00000195419 XPO1 XPO1 2p15 Approved CRM1 exportin 1 (CRM1 homolog, yeast); Mediates the nuclear export of cellular proteins (cargos) bearing a leucine-rich nuclear export signal (NES) and of RNAs. In the nucleus, in association with RANBP3, binds cooperatively to the NES on its target protein and to the GTPase RAN in its active GTP-bound form (Ran-GTP). Docking of this complex to the nuclear pore complex (NPC) is mediated through binding to nucleoporins. Upon transit of an nuclear export complex into the cytoplasm, disassembling of the complex and hydrolysis of Ran-GTP to Ran-GDP (induced by RANBP1 and RANGAP1, respectively) [...]
9183 ZW10 9183 HGNC:13194 Hs.503886 204812_at
ZW10, kinetochore associated, homolog (Drosophila) ZW10, kinetochore associated, homolog (Drosophila) ENSG00000086827 ENSP00000200135 ZW10 ZW10 11q23 Approved KNTC1AP ZW10 ZW10, kinetochore associated, homolog (Drosophila); Essential component of the mitotic checkpoint, which prevents cells from prematurely exiting mitosis. Required for the assembly of the dynein-dynactin and MAD1-MAD2 complexes onto kinetochores. Involved in regulation of membrane traffic between the Golgi and the endoplasmic reticulum
55055 ZWILCH 55055 HGNC:25468 Hs.21331 218349_s_at
222606_at
Zwilch, kinetochore associated, homolog (Drosophila) Zwilch, kinetochore associated, homolog (Drosophila) ENSG00000174442 ENSP00000311429 ZWILCH ZWILCH 15q22.31 Approved FLJ10036, KNTC1AP ZWILCH Zwilch, kinetochore associated, homolog (Drosophila); Essential component of the mitotic checkpoint, which prevents cells from prematurely exiting mitosis. Required for the assembly of the dynein-dynactin and MAD1-MAD2 complexes onto kinetochores
11130 ZWINT 11130 HGNC:13195 Hs.591363 ZW10 interactor ZW10 interactor antisense ENSG00000122952 ENSP00000363055 ZWINT ZWINT 10q21-q22 Approved KNTC2AP ZWINT ZW10 interactor; Part of the MIS12 complex, which is required for kinetochore formation and spindle checkpoint activity. Required to target ZW10 to the kinetochore at prometaphase
178 genes found.

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ID ApprovedSymbol EntrezGene HGNC
UniGeneID HugoName UniGeneName GeneOntologyID
ENSG ENSP KEGGID ApprovedSymbol2
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