Ontocancro Pathways

There are several genes mentioned in the literature and databases with evidences of involvement in GMM which are not included in the specific pathway definition in some databases generating disagreements and this is due to the fact that many gene pathways are still under investigation. To deal with this additional information we created expanded versions of GMM pathways to include these genes and which we call Ontocancro pathways.

Some of these genes were obtained from the Gene Ontology and they were included in Ontocancro taking into consideration the most reliable evidences of functional involvement of a gene according to the GO criteria of evidences as follows (see http://www.geneontology.org/GO.evidence.shtml): Inferred from Experiment (EXP), Inferred by Curator (IC), Inferred from Direct Assay (IDA), Inferred from Expression Pattern (IEP), Inferred from Genetic Interaction (IGI), Inferred from Mutant Phenotype (IMP), and Inferred from Physical Interaction (IPI).